Q4GHL2 · Q4GHL2_HUMAN

  • Protein
    NADH-ubiquinone oxidoreductase chain 5
  • Gene
    NADH5
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespirasome
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Biological ProcessATP synthesis coupled electron transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 5
  • EC number

Gene names

    • Name
      NADH5
    • Synonyms
      ND5
      , ndh5

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • MTDNA341
    • HNsq0157
    • JDsq0061
    • JDsq0077
    • KAsq0033
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q4GHL2

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane84-105Helical
Transmembrane117-134Helical
Transmembrane140-160Helical
Transmembrane172-191Helical
Transmembrane211-233Helical
Transmembrane245-266Helical
Transmembrane272-294Helical
Transmembrane301-319Helical
Transmembrane325-347Helical
Transmembrane368-386Helical
Transmembrane406-433Helical
Transmembrane454-472Helical
Transmembrane484-507Helical
Transmembrane584-602Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_501013855622-603NADH-ubiquinone oxidoreductase chain 5

Proteomic databases

Interaction

Subunit

Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain68-118NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Domain134-419NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Domain422-602NADH dehydrogenase subunit 5 C-terminal

Sequence similarities

Belongs to the complex I subunit 5 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    603
  • Mass (Da)
    66,992
  • Last updated
    2005-08-30 v1
  • Checksum
    86E999E292AF3069
MTMHTTMTTLTLTSLIPPILTTLVNPNKKNSYPHYVKSIVASTFIISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIMEFSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYARADANTAAIQAILYNRIGDIGLILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLLAAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTLTLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSKDHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPTLLNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLTNKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTISQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ272123
EMBL· GenBank· DDBJ
ABB51460.1
EMBL· GenBank· DDBJ
Genomic DNA
EF657500
EMBL· GenBank· DDBJ
ABR96471.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ705952
EMBL· GenBank· DDBJ
AFG15344.1
EMBL· GenBank· DDBJ
Genomic DNA
KC911440
EMBL· GenBank· DDBJ
AGO92470.1
EMBL· GenBank· DDBJ
Genomic DNA
KP900744
EMBL· GenBank· DDBJ
AKI30482.1
EMBL· GenBank· DDBJ
Genomic DNA
MH448980
EMBL· GenBank· DDBJ
AYW04462.1
EMBL· GenBank· DDBJ
Genomic DNA
MH981859
EMBL· GenBank· DDBJ
AZJ14147.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008276
EMBL· GenBank· DDBJ
BAE07581.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008324
EMBL· GenBank· DDBJ
BAE08205.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008349
EMBL· GenBank· DDBJ
BAE08530.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008363
EMBL· GenBank· DDBJ
BAE08712.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008396
EMBL· GenBank· DDBJ
BAE09141.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008433
EMBL· GenBank· DDBJ
BAE09622.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008471
EMBL· GenBank· DDBJ
BAE10116.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008510
EMBL· GenBank· DDBJ
BAE10623.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008532
EMBL· GenBank· DDBJ
BAE10911.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008547
EMBL· GenBank· DDBJ
BAE11106.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008576
EMBL· GenBank· DDBJ
BAE11483.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008581
EMBL· GenBank· DDBJ
BAE11548.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008606
EMBL· GenBank· DDBJ
BAE11873.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008622
EMBL· GenBank· DDBJ
BAE12081.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008644
EMBL· GenBank· DDBJ
BAE12367.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008748
EMBL· GenBank· DDBJ
BAE13719.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008761
EMBL· GenBank· DDBJ
BAE13888.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008762
EMBL· GenBank· DDBJ
BAE13901.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008785
EMBL· GenBank· DDBJ
BAE14200.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008878
EMBL· GenBank· DDBJ
BAE15409.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008893
EMBL· GenBank· DDBJ
BAE15604.1
EMBL· GenBank· DDBJ
Genomic DNA
AP010701
EMBL· GenBank· DDBJ
BAG14923.1
EMBL· GenBank· DDBJ
Genomic DNA
AP009429
EMBL· GenBank· DDBJ
BAG38847.1
EMBL· GenBank· DDBJ
Genomic DNA
AP009455
EMBL· GenBank· DDBJ
BAG39185.1
EMBL· GenBank· DDBJ
Genomic DNA
AP011024
EMBL· GenBank· DDBJ
BAH16097.1
EMBL· GenBank· DDBJ
Genomic DNA
AP013177
EMBL· GenBank· DDBJ
BAN80187.1
EMBL· GenBank· DDBJ
Genomic DNA
MK059623
EMBL· GenBank· DDBJ
QCB18317.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp