Q4G7P9 · Q4G7P9_HUMAN

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processoxidative phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI
    • Synonyms
      COX1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • JDsq0073
    • DH061
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q4G7P9

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane18-37Helical
Transmembrane57-83Helical
Transmembrane104-128Helical
Transmembrane148-171Helical
Transmembrane183-210Helical
Transmembrane243-261Helical
Transmembrane268-291Helical
Transmembrane303-325Helical
Transmembrane337-359Helical
Transmembrane379-400Helical
Transmembrane412-430Helical
Transmembrane450-473Helical

Keywords

PTM/Processing

Proteomic databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-511Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    513
  • Mass (Da)
    57,011
  • Last updated
    2005-08-30 v1
  • Checksum
    9FC223495250BA02
MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNMKWSAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEPVYMKS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GQ272387
EMBL· GenBank· DDBJ
ACS48534.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ873547
EMBL· GenBank· DDBJ
ADY75151.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ324684
EMBL· GenBank· DDBJ
AFA30654.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ324926
EMBL· GenBank· DDBJ
AFA33800.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ703739
EMBL· GenBank· DDBJ
AFF86567.1
EMBL· GenBank· DDBJ
Genomic DNA
JX900629
EMBL· GenBank· DDBJ
AGC19193.1
EMBL· GenBank· DDBJ
Genomic DNA
KF540762
EMBL· GenBank· DDBJ
AGZ09200.1
EMBL· GenBank· DDBJ
Genomic DNA
KF540772
EMBL· GenBank· DDBJ
AGZ09330.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ185404
EMBL· GenBank· DDBJ
AID07663.1
EMBL· GenBank· DDBJ
Genomic DNA
KM101682
EMBL· GenBank· DDBJ
AIU58567.1
EMBL· GenBank· DDBJ
Genomic DNA
KX456569
EMBL· GenBank· DDBJ
APD54429.1
EMBL· GenBank· DDBJ
Genomic DNA
MF057047
EMBL· GenBank· DDBJ
ASS10515.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008889
EMBL· GenBank· DDBJ
BAE15544.1
EMBL· GenBank· DDBJ
Genomic DNA
MN628086
EMBL· GenBank· DDBJ
QXO91682.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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