Q4G7F8 · Q4G7F8_HUMAN
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids513 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2OThis reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
Protein has several cofactor binding sites:
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | oxidative phosphorylation |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ4G7F8
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 18-37 | Helical | ||||
Sequence: LYLLFGAWAGVLGTALSLLI | ||||||
Transmembrane | 57-83 | Helical | ||||
Sequence: IVTAHAFVMIFFMVMPIMIGGFGNWLV | ||||||
Transmembrane | 104-128 | Helical | ||||
Sequence: LLPPSLLLLLASAMVETGAGTGWTV | ||||||
Transmembrane | 148-171 | Helical | ||||
Sequence: FSLHLAGVSSILGAINFITTIINM | ||||||
Transmembrane | 183-210 | Helical | ||||
Sequence: LFVWSVLITAVLLLLSLPVLAAGITMLL | ||||||
Transmembrane | 243-261 | Helical | ||||
Sequence: VYILILPGFGMISHIVTYY | ||||||
Transmembrane | 268-291 | Helical | ||||
Sequence: FGYMGMVWAMMSIGFLGFIVWAHH | ||||||
Transmembrane | 303-325 | Helical | ||||
Sequence: AYFTSATMIIAIPTGVKVFSWLA | ||||||
Transmembrane | 337-359 | Helical | ||||
Sequence: AVLWALGFIFLFTVGGLTGIVLA | ||||||
Transmembrane | 379-400 | Helical | ||||
Sequence: YVLSMGAVFAIMGGFIHWFPLF | ||||||
Transmembrane | 412-430 | Helical | ||||
Sequence: IHFTIMFIGVNLTFFPQHF | ||||||
Transmembrane | 450-473 | Helical | ||||
Sequence: WNILSSVGSFISLTAVMLMIFMIW |
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-511 | Cytochrome oxidase subunit I profile | ||||
Sequence: MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVETGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEPVYM |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length513
- Mass (Da)57,071
- Last updated2005-08-30 v1
- ChecksumAC5769A5F6E4FE47
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DQ112780 EMBL· GenBank· DDBJ | AAZ01010.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ305013 EMBL· GenBank· DDBJ | ABB99065.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ523629 EMBL· GenBank· DDBJ | ABF48862.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF222243 EMBL· GenBank· DDBJ | ABM68794.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF556160 EMBL· GenBank· DDBJ | ABP99220.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF660941 EMBL· GenBank· DDBJ | ABR57901.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF657314 EMBL· GenBank· DDBJ | ABR94049.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ460526 EMBL· GenBank· DDBJ | ACJ47314.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ951612 EMBL· GenBank· DDBJ | ACQ76169.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ301876 EMBL· GenBank· DDBJ | ACT15804.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM765471 EMBL· GenBank· DDBJ | ADK66661.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM771231 EMBL· GenBank· DDBJ | ADL16364.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ012167 EMBL· GenBank· DDBJ | ADM60114.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ651704 EMBL· GenBank· DDBJ | ADU77849.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ700846 EMBL· GenBank· DDBJ | ADV38424.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JF833037 EMBL· GenBank· DDBJ | AEE11715.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JF824836 EMBL· GenBank· DDBJ | AEG62418.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ044972 EMBL· GenBank· DDBJ | AEV49205.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ701934 EMBL· GenBank· DDBJ | AFF63102.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ798091 EMBL· GenBank· DDBJ | AFI53933.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX152808 EMBL· GenBank· DDBJ | AFO20679.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX297170 EMBL· GenBank· DDBJ | AFP98377.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX900752 EMBL· GenBank· DDBJ | AGC20792.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC577360 EMBL· GenBank· DDBJ | AGI49209.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC622055 EMBL· GenBank· DDBJ | AGJ95189.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC533463 EMBL· GenBank· DDBJ | AGK64259.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC911358 EMBL· GenBank· DDBJ | AGO91396.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF541029 EMBL· GenBank· DDBJ | AGZ12671.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF450996 EMBL· GenBank· DDBJ | AGZ66583.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF836133 EMBL· GenBank· DDBJ | AHG98493.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ154197 EMBL· GenBank· DDBJ | AHW30222.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ185456 EMBL· GenBank· DDBJ | AID08339.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ856795 EMBL· GenBank· DDBJ | AIN38830.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM101681 EMBL· GenBank· DDBJ | AIU58554.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP317002 EMBL· GenBank· DDBJ | AJT35632.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM986530 EMBL· GenBank· DDBJ | AJV87066.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR074236 EMBL· GenBank· DDBJ | AKV62345.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT819255 EMBL· GenBank· DDBJ | ALM03864.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX456447 EMBL· GenBank· DDBJ | APD52843.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX440341 EMBL· GenBank· DDBJ | APS90259.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY399143 EMBL· GenBank· DDBJ | AQU13078.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY824922 EMBL· GenBank· DDBJ | ARK16367.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY782249 EMBL· GenBank· DDBJ | ASC44358.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF362741 EMBL· GenBank· DDBJ | ASF84329.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF362893 EMBL· GenBank· DDBJ | ASF86305.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645842 EMBL· GenBank· DDBJ | ASR16725.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF055747 EMBL· GenBank· DDBJ | ASR93638.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF498665 EMBL· GenBank· DDBJ | ASY00250.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY797263 EMBL· GenBank· DDBJ | ATO58752.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF177183 EMBL· GenBank· DDBJ | AUR39847.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG273067 EMBL· GenBank· DDBJ | AVL91293.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF991441 EMBL· GenBank· DDBJ | AWW03300.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG182505 EMBL· GenBank· DDBJ | AXF37046.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH981649 EMBL· GenBank· DDBJ | AYV90643.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH981912 EMBL· GenBank· DDBJ | AZJ14828.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008278 EMBL· GenBank· DDBJ | BAE07599.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008776 EMBL· GenBank· DDBJ | BAE14075.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008896 EMBL· GenBank· DDBJ | BAE15635.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP012349 EMBL· GenBank· DDBJ | BAM25111.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK059617 EMBL· GenBank· DDBJ | QCB18231.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN503412 EMBL· GenBank· DDBJ | QEW88533.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN540565 EMBL· GenBank· DDBJ | QGL54562.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK134282 EMBL· GenBank· DDBJ | QGW53963.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN849749 EMBL· GenBank· DDBJ | QKT25273.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN687222 EMBL· GenBank· DDBJ | QLH91716.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT419178 EMBL· GenBank· DDBJ | QMP93837.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW172477 EMBL· GenBank· DDBJ | QPL16472.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN857384 EMBL· GenBank· DDBJ | QTK15549.1 EMBL· GenBank· DDBJ | Genomic DNA |