Q4G7F8 · Q4G7F8_HUMAN

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processoxidative phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI
    • Synonyms
      COX1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 1429
    • MTDNA174
    • JDsq0080
    • NDsq0116
    • TCsq0019
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q4G7F8

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane18-37Helical
Transmembrane57-83Helical
Transmembrane104-128Helical
Transmembrane148-171Helical
Transmembrane183-210Helical
Transmembrane243-261Helical
Transmembrane268-291Helical
Transmembrane303-325Helical
Transmembrane337-359Helical
Transmembrane379-400Helical
Transmembrane412-430Helical
Transmembrane450-473Helical

Keywords

PTM/Processing

Proteomic databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-511Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    513
  • Mass (Da)
    57,071
  • Last updated
    2005-08-30 v1
  • Checksum
    AC5769A5F6E4FE47
MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVETGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEPVYMKS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ112780
EMBL· GenBank· DDBJ
AAZ01010.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ305013
EMBL· GenBank· DDBJ
ABB99065.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ523629
EMBL· GenBank· DDBJ
ABF48862.1
EMBL· GenBank· DDBJ
Genomic DNA
EF222243
EMBL· GenBank· DDBJ
ABM68794.1
EMBL· GenBank· DDBJ
Genomic DNA
EF556160
EMBL· GenBank· DDBJ
ABP99220.1
EMBL· GenBank· DDBJ
Genomic DNA
EF660941
EMBL· GenBank· DDBJ
ABR57901.1
EMBL· GenBank· DDBJ
Genomic DNA
EF657314
EMBL· GenBank· DDBJ
ABR94049.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ460526
EMBL· GenBank· DDBJ
ACJ47314.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ951612
EMBL· GenBank· DDBJ
ACQ76169.1
EMBL· GenBank· DDBJ
Genomic DNA
GQ301876
EMBL· GenBank· DDBJ
ACT15804.1
EMBL· GenBank· DDBJ
Genomic DNA
HM765471
EMBL· GenBank· DDBJ
ADK66661.1
EMBL· GenBank· DDBJ
Genomic DNA
HM771231
EMBL· GenBank· DDBJ
ADL16364.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ012167
EMBL· GenBank· DDBJ
ADM60114.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ651704
EMBL· GenBank· DDBJ
ADU77849.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ700846
EMBL· GenBank· DDBJ
ADV38424.1
EMBL· GenBank· DDBJ
Genomic DNA
JF833037
EMBL· GenBank· DDBJ
AEE11715.1
EMBL· GenBank· DDBJ
Genomic DNA
JF824836
EMBL· GenBank· DDBJ
AEG62418.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ044972
EMBL· GenBank· DDBJ
AEV49205.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ701934
EMBL· GenBank· DDBJ
AFF63102.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ798091
EMBL· GenBank· DDBJ
AFI53933.1
EMBL· GenBank· DDBJ
Genomic DNA
JX152808
EMBL· GenBank· DDBJ
AFO20679.1
EMBL· GenBank· DDBJ
Genomic DNA
JX297170
EMBL· GenBank· DDBJ
AFP98377.1
EMBL· GenBank· DDBJ
Genomic DNA
JX900752
EMBL· GenBank· DDBJ
AGC20792.1
EMBL· GenBank· DDBJ
Genomic DNA
KC577360
EMBL· GenBank· DDBJ
AGI49209.1
EMBL· GenBank· DDBJ
Genomic DNA
KC622055
EMBL· GenBank· DDBJ
AGJ95189.1
EMBL· GenBank· DDBJ
Genomic DNA
KC533463
EMBL· GenBank· DDBJ
AGK64259.1
EMBL· GenBank· DDBJ
Genomic DNA
KC911358
EMBL· GenBank· DDBJ
AGO91396.1
EMBL· GenBank· DDBJ
Genomic DNA
KF541029
EMBL· GenBank· DDBJ
AGZ12671.1
EMBL· GenBank· DDBJ
Genomic DNA
KF450996
EMBL· GenBank· DDBJ
AGZ66583.1
EMBL· GenBank· DDBJ
Genomic DNA
KF836133
EMBL· GenBank· DDBJ
AHG98493.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ154197
EMBL· GenBank· DDBJ
AHW30222.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ185456
EMBL· GenBank· DDBJ
AID08339.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ856795
EMBL· GenBank· DDBJ
AIN38830.1
EMBL· GenBank· DDBJ
Genomic DNA
KM101681
EMBL· GenBank· DDBJ
AIU58554.1
EMBL· GenBank· DDBJ
Genomic DNA
KP317002
EMBL· GenBank· DDBJ
AJT35632.1
EMBL· GenBank· DDBJ
Genomic DNA
KM986530
EMBL· GenBank· DDBJ
AJV87066.1
EMBL· GenBank· DDBJ
Genomic DNA
KR074236
EMBL· GenBank· DDBJ
AKV62345.1
EMBL· GenBank· DDBJ
Genomic DNA
KT819255
EMBL· GenBank· DDBJ
ALM03864.1
EMBL· GenBank· DDBJ
Genomic DNA
KX456447
EMBL· GenBank· DDBJ
APD52843.1
EMBL· GenBank· DDBJ
Genomic DNA
KX440341
EMBL· GenBank· DDBJ
APS90259.1
EMBL· GenBank· DDBJ
Genomic DNA
KY399143
EMBL· GenBank· DDBJ
AQU13078.1
EMBL· GenBank· DDBJ
Genomic DNA
KY824922
EMBL· GenBank· DDBJ
ARK16367.1
EMBL· GenBank· DDBJ
Genomic DNA
KY782249
EMBL· GenBank· DDBJ
ASC44358.1
EMBL· GenBank· DDBJ
Genomic DNA
MF362741
EMBL· GenBank· DDBJ
ASF84329.1
EMBL· GenBank· DDBJ
Genomic DNA
MF362893
EMBL· GenBank· DDBJ
ASF86305.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645842
EMBL· GenBank· DDBJ
ASR16725.1
EMBL· GenBank· DDBJ
Genomic DNA
MF055747
EMBL· GenBank· DDBJ
ASR93638.1
EMBL· GenBank· DDBJ
Genomic DNA
MF498665
EMBL· GenBank· DDBJ
ASY00250.1
EMBL· GenBank· DDBJ
Genomic DNA
KY797263
EMBL· GenBank· DDBJ
ATO58752.2
EMBL· GenBank· DDBJ
Genomic DNA
MF177183
EMBL· GenBank· DDBJ
AUR39847.1
EMBL· GenBank· DDBJ
Genomic DNA
MG273067
EMBL· GenBank· DDBJ
AVL91293.1
EMBL· GenBank· DDBJ
Genomic DNA
MF991441
EMBL· GenBank· DDBJ
AWW03300.1
EMBL· GenBank· DDBJ
Genomic DNA
MG182505
EMBL· GenBank· DDBJ
AXF37046.1
EMBL· GenBank· DDBJ
Genomic DNA
MH981649
EMBL· GenBank· DDBJ
AYV90643.1
EMBL· GenBank· DDBJ
Genomic DNA
MH981912
EMBL· GenBank· DDBJ
AZJ14828.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008278
EMBL· GenBank· DDBJ
BAE07599.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008776
EMBL· GenBank· DDBJ
BAE14075.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008896
EMBL· GenBank· DDBJ
BAE15635.1
EMBL· GenBank· DDBJ
Genomic DNA
AP012349
EMBL· GenBank· DDBJ
BAM25111.1
EMBL· GenBank· DDBJ
Genomic DNA
MK059617
EMBL· GenBank· DDBJ
QCB18231.1
EMBL· GenBank· DDBJ
Genomic DNA
MN503412
EMBL· GenBank· DDBJ
QEW88533.1
EMBL· GenBank· DDBJ
Genomic DNA
MN540565
EMBL· GenBank· DDBJ
QGL54562.1
EMBL· GenBank· DDBJ
Genomic DNA
MK134282
EMBL· GenBank· DDBJ
QGW53963.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849749
EMBL· GenBank· DDBJ
QKT25273.1
EMBL· GenBank· DDBJ
Genomic DNA
MN687222
EMBL· GenBank· DDBJ
QLH91716.1
EMBL· GenBank· DDBJ
Genomic DNA
MT419178
EMBL· GenBank· DDBJ
QMP93837.1
EMBL· GenBank· DDBJ
Genomic DNA
MW172477
EMBL· GenBank· DDBJ
QPL16472.1
EMBL· GenBank· DDBJ
Genomic DNA
MN857384
EMBL· GenBank· DDBJ
QTK15549.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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