Q4G6P4 · Q4G6P4_HUMAN
- ProteinCytochrome c oxidase subunit 3
- GeneCOIII
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids261 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)This reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | mitochondrion | |
Molecular Function | cytochrome-c oxidase activity | |
Biological Process | aerobic electron transport chain |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 3
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ4G6P4
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 16-35 | Helical | |||
Transmembrane | 41-58 | Helical | |||
Transmembrane | 79-102 | Helical | |||
Transmembrane | 159-177 | Helical | |||
Transmembrane | 197-220 | Helical | |||
Transmembrane | 240-260 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length261
- Mass (Da)29,924
- Last updated2005-08-30 v1
- Checksum0DA1A437A7A55B31
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EF417833 EMBL· GenBank· DDBJ | ABN13452.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM771154 EMBL· GenBank· DDBJ | ADL15367.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM771155 EMBL· GenBank· DDBJ | ADL15380.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX669399 EMBL· GenBank· DDBJ | AFV56906.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC765917 EMBL· GenBank· DDBJ | AGH20733.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF451023 EMBL· GenBank· DDBJ | AGZ66938.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF451033 EMBL· GenBank· DDBJ | AGZ67068.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ445786 EMBL· GenBank· DDBJ | AHX43278.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ445787 EMBL· GenBank· DDBJ | AHX43291.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP340171 EMBL· GenBank· DDBJ | AKH35845.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF056587 EMBL· GenBank· DDBJ | ASS04564.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY941906 EMBL· GenBank· DDBJ | ASU93649.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG546008 EMBL· GenBank· DDBJ | ATW75525.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008777 EMBL· GenBank· DDBJ | BAE14092.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008916 EMBL· GenBank· DDBJ | BAE15899.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP009464 EMBL· GenBank· DDBJ | BAG39298.1 EMBL· GenBank· DDBJ | Genomic DNA |