Q4G6P4 · Q4G6P4_HUMAN

  • Protein
    Cytochrome c oxidase subunit 3
  • Gene
    COIII
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentmembrane
Cellular Componentmitochondrion
Molecular Functioncytochrome-c oxidase activity
Biological Processaerobic electron transport chain

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 3

Gene names

    • Name
      COIII
    • Synonyms
      COX3

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • JDsq0100
    • NDsq0117
    • Mdmd46
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q4G6P4

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane16-35Helical
Transmembrane41-58Helical
Transmembrane79-102Helical
Transmembrane159-177Helical
Transmembrane197-220Helical
Transmembrane240-260Helical

Keywords

PTM/Processing

Proteomic databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-261Heme-copper oxidase subunit III family profile

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    261
  • Mass (Da)
    29,924
  • Last updated
    2005-08-30 v1
  • Checksum
    0DA1A437A7A55B31
MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLMLGLLTSTLTMYQWWRDVTRESTYQGHHTPPVQKGLRYGMILFITSEVFFFAGFFWAFYHSSLAPTPQLGGHWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMENNRNQMIQALLITILLGLYFTLLQASEYFESPFTISDGIYGSTFFVATGFHGLHVIIGSTFLTICFIRQLMFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EF417833
EMBL· GenBank· DDBJ
ABN13452.2
EMBL· GenBank· DDBJ
Genomic DNA
HM771154
EMBL· GenBank· DDBJ
ADL15367.1
EMBL· GenBank· DDBJ
Genomic DNA
HM771155
EMBL· GenBank· DDBJ
ADL15380.1
EMBL· GenBank· DDBJ
Genomic DNA
JX669399
EMBL· GenBank· DDBJ
AFV56906.1
EMBL· GenBank· DDBJ
Genomic DNA
KC765917
EMBL· GenBank· DDBJ
AGH20733.1
EMBL· GenBank· DDBJ
Genomic DNA
KF451023
EMBL· GenBank· DDBJ
AGZ66938.1
EMBL· GenBank· DDBJ
Genomic DNA
KF451033
EMBL· GenBank· DDBJ
AGZ67068.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ445786
EMBL· GenBank· DDBJ
AHX43278.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ445787
EMBL· GenBank· DDBJ
AHX43291.1
EMBL· GenBank· DDBJ
Genomic DNA
KP340171
EMBL· GenBank· DDBJ
AKH35845.1
EMBL· GenBank· DDBJ
Genomic DNA
MF056587
EMBL· GenBank· DDBJ
ASS04564.1
EMBL· GenBank· DDBJ
Genomic DNA
KY941906
EMBL· GenBank· DDBJ
ASU93649.1
EMBL· GenBank· DDBJ
Genomic DNA
MG546008
EMBL· GenBank· DDBJ
ATW75525.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008777
EMBL· GenBank· DDBJ
BAE14092.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008916
EMBL· GenBank· DDBJ
BAE15899.1
EMBL· GenBank· DDBJ
Genomic DNA
AP009464
EMBL· GenBank· DDBJ
BAG39298.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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