Q4G3H4 · IKKA_DANRE
- ProteinInhibitor of nuclear factor kappa-B kinase subunit alpha
- Genechuk
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids758 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.
Catalytic activity
- ATP + L-seryl-[I-kappa-B protein] = ADP + H+ + O-phospho-L-seryl-[I-kappa-B protein]
Activity regulation
Activated when phosphorylated and inactivated when dephosphorylated.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | IkappaB kinase complex | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | IkappaB kinase activity | |
Molecular Function | protein heterodimerization activity | |
Molecular Function | protein homodimerization activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | cellular response to tumor necrosis factor | |
Biological Process | central nervous system development | |
Biological Process | epiboly involved in gastrulation with mouth forming second | |
Biological Process | negative regulation of apoptotic process | |
Biological Process | negative regulation of canonical NF-kappaB signal transduction | |
Biological Process | positive regulation of transcription by RNA polymerase II | |
Biological Process | somite specification | |
Biological Process | tumor necrosis factor-mediated signaling pathway |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInhibitor of nuclear factor kappa-B kinase subunit alpha
- EC number
- Short namesI kappa-B kinase alpha; IKK-A; IKK-alpha; IkBKA; IkappaB kinase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ4G3H4
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000268827 | 1-758 | Inhibitor of nuclear factor kappa-B kinase subunit alpha | |||
Sequence: MEKPPFRQNQVCGSWVMKERLGTGGFGHVYLYQNQETSEKIAVKLCRLELNSKNKDRWSRGIQIMKKLKHLNVVTAKDVPEEMMHIALNDLPLLAMEYCSKGDLRKLLSKPENCCGLKESEVLSLLNDVGSGIQYLHENKIIHRDLKPENIVLQEINGKLVHKIIDLGYAKDLDQGSLCTSFVGTLQYLAPELFEGKSYTVTVDFWSFGTMIFECCCGFRPFLHNLQPVQWTSKVRNKGPKDIMAVEDMNGEVRFSTHLPYPNNLSRTLLEPLEGLLQLMLKWDPVQRGLGLNTDSKQPQCFVLLDQILSMKVVHILNMTTTQVHSFLLSPDEGLHSLQQRIENETKIELLNQDLLQETGVMSDPRKPAAQCVLDGVRGWDSYIVYLFDKSLTKYMGPLTARTLPESVNFIVRETKTQLPLSTLKKVWGEAVSYICGLREDYSRLFQGQRAAMLSLLRFNTNLTRYKNMMFSFSQQLKAKLDFFKTSIQYDLEKYSDQMQYGISSEKMLKAWHENEERAAAFAQVAEIGHLDEEIMALHSEIVELQRSPYARRQGDVMEQLQEKAIELYKQLKAKCKMPDPQHGYSDSSEMVKVIVQTVQNQDRVLRDLYAHLSKILLSKQKIIDLFPKIERTLECIKEADTTVMQMQIKRQREFWHLLKIACAQNTTRSSVSQSGEMPSSLSTWNQTQAQCSSRLPMSLQVPHEGDSVNHLLEENQRYLTQLTSLLQETTEEKSESIMAQDWSWTKYESLVAKSPRL |
Keywords
- PTM
Proteomic databases
Expression
Developmental stage
Abundantly expressed from the blastula period through early gastrulation. During early somitogenesis, transcripts are dorsally localized at the level of the segmental plate and the presumptive notochord. At the 18-somite stage, expression becomes largely detectable throughout the somitic tissue At late embryonic stages, expression is particularly evident in the tectum, cerebellum, hindbrain region, and eyes. After hatching, transcripts can also be detected in the myotomes and pectoral fins.
Interaction
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 15-301 | Protein kinase | ||||
Sequence: WVMKERLGTGGFGHVYLYQNQETSEKIAVKLCRLELNSKNKDRWSRGIQIMKKLKHLNVVTAKDVPEEMMHIALNDLPLLAMEYCSKGDLRKLLSKPENCCGLKESEVLSLLNDVGSGIQYLHENKIIHRDLKPENIVLQEINGKLVHKIIDLGYAKDLDQGSLCTSFVGTLQYLAPELFEGKSYTVTVDFWSFGTMIFECCCGFRPFLHNLQPVQWTSKVRNKGPKDIMAVEDMNGEVRFSTHLPYPNNLSRTLLEPLEGLLQLMLKWDPVQRGLGLNTDSKQPQC | ||||||
Region | 456-477 | Leucine-zipper | ||||
Sequence: LLRFNTNLTRYKNMMFSFSQQL | ||||||
Region | 741-746 | NEMO-binding | ||||
Sequence: QDWSWT |
Sequence similarities
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length758
- Mass (Da)87,147
- Last updated2005-08-30 v1
- Checksum9E3355AEAE5EE7F7
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 61 | in Ref. 1; AAW68010 | ||||
Sequence: G → E | ||||||
Sequence conflict | 363 | in Ref. 1; AAW68010 | ||||
Sequence: S → L | ||||||
Sequence conflict | 438 | in Ref. 1; AAW68010 | ||||
Sequence: L → P | ||||||
Sequence conflict | 617 | in Ref. 1; AAW68010 | ||||
Sequence: L → P | ||||||
Sequence conflict | 756 | in Ref. 1; AAW68010 | ||||
Sequence: P → A |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY735397 EMBL· GenBank· DDBJ | AAW68010.1 EMBL· GenBank· DDBJ | mRNA | ||
BC051614 EMBL· GenBank· DDBJ | AAH51614.1 EMBL· GenBank· DDBJ | mRNA |