Q4G1C9 · GRPL2_HUMAN

  • Protein
    GLIPR1-like protein 2
  • Gene
    GLIPR1L2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Cellular Componentmembrane

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GLIPR1-like protein 2

Gene names

    • Name
      GLIPR1L2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q4G1C9
  • Secondary accessions
    • Q6MZS1
    • Q8N6N0
    • Q8NA43

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane254-274Helical

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 462 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003243871-344GLIPR1-like protein 2

Proteomic databases

PTM databases

Expression

Tissue specificity

Highly expressed in testis. Detected in prostate, kidney, bladder, lung and bone marrow.

Induction

Up-regulated by doxycycline.

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q4G1C9-2PECAM1 P162843EBI-20835942, EBI-716404
BINARY Q4G1C9-2UBE2K P610863EBI-20835942, EBI-473850
BINARY Q4G1C9-2VIM P086703EBI-20835942, EBI-353844

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain58-192SCP
Region292-344Disordered
Compositional bias315-344Acidic residues

Sequence similarities

Belongs to the CRISP family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (6)
  • Sequence status
    Complete

This entry describes 6 isoforms produced by Alternative splicing.

Q4G1C9-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    delta
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    344
  • Mass (Da)
    40,179
  • Last updated
    2008-03-18 v2
  • Checksum
    8D19B8CB2CEC5786
MEAARPFAREWRAQSLPLAVGGVLKLRLCELWLLLLGSSLNARFLPDEEDVDFINEYVNLHNELRGDVIPRGSNLRFMTWDVALSRTARAWGKKCLFTHNIYLQDVQMVHPKFYGIGENMWVGPENEFTASIAIRSWHAEKKMYNFENGSCSGDCSNYIQLVWDHSYKVGCAVTPCSKIGHIIHAAIFICNYAPGGTLTRRPYEPGIFCTRCGRRDKCTDFLCSNADRDQATYYRFWYPKWEMPRPVVCDPLCTFILLLRILCFILCVITVLIVQSQFPNILLEQQMIFTPEESEAGNEEEEKEEEKKEKEEMEMEIMEMEEEKEEREEEEEETQKEKMEEEEK

Q4G1C9-2

  • Name
    2
  • Synonyms
    alpha
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 225-344: NADRDQATYYRFWYPKWEMPRPVVCDPLCTFILLLRILCFILCVITVLIVQSQFPNILLEQQMIFTPEESEAGNEEEEKEEEKKEKEEMEMEIMEMEEEKEEREEEEEETQKEKMEEEEK → KIKKINMKKMHNGLDKKNKRLNTSFLWSC

Q4G1C9-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 79-106: TWDVALSRTARAWGKKCLFTHNIYLQDV → LWYCCDSDGSRFIIGFPNLSPRTPSAPL
    • 107-344: Missing

Q4G1C9-4

  • Name
    4
  • Synonyms
    epsilon
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q4G1C9-5

  • Name
    5
  • Synonyms
    gamma
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q4G1C9-6

  • Name
    6
  • Synonyms
    beta
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Sequence caution

The sequence AAH16749.1 differs from that shown. Reason: Miscellaneous discrepancy Contaminating sequence. Potential poly-A sequence.
The sequence BAC04085.1 differs from that shown. Reason: Erroneous termination Truncated C-terminus.
The sequence CAE45957.1 differs from that shown. Reason: Erroneous initiation

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0322401-77in isoform 6
Alternative sequenceVSP_0322391-107in isoform 5
Alternative sequenceVSP_03224178in isoform 6
Alternative sequenceVSP_03224279-106in isoform 3
Alternative sequenceVSP_032243107-344in isoform 3
Alternative sequenceVSP_032244161in isoform 4
Alternative sequenceVSP_032245162-344in isoform 4
Alternative sequenceVSP_032246225-344in isoform 2
Compositional bias315-344Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK093175
EMBL· GenBank· DDBJ
BAC04085.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
BX640916
EMBL· GenBank· DDBJ
CAE45957.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AC121761
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471054
EMBL· GenBank· DDBJ
EAW97305.1
EMBL· GenBank· DDBJ
Genomic DNA
BC016749
EMBL· GenBank· DDBJ
AAH16749.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
BC029557
EMBL· GenBank· DDBJ
AAH29557.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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