Q4FJV4 · Q4FJV4_MOUSE

Function

function

Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Promotes resolution of inflammation and wound healing. Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentactin filament
Cellular Componentapical plasma membrane
Cellular Componentbasolateral plasma membrane
Cellular Componentcell surface
Cellular Componentcilium
Cellular Componentcornified envelope
Cellular Componentcytosol
Cellular Componentearly endosome
Cellular Componentendosome membrane
Cellular Componentextracellular exosome
Cellular Componentlateral plasma membrane
Cellular Componentnucleoplasm
Cellular Componentphagocytic cup
Molecular Functioncalcium ion binding
Molecular Functioncalcium-dependent phospholipid binding
Molecular Functioncalcium-dependent protein binding
Molecular Functionphospholipase A2 inhibitor activity
Biological Processactin cytoskeleton organization
Biological Processadaptive immune response
Biological Processcellular response to glucocorticoid stimulus
Biological Processcellular response to vascular endothelial growth factor stimulus
Biological ProcessG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Biological Processgranulocyte chemotaxis
Biological Processkeratinocyte differentiation
Biological Processmonocyte chemotaxis
Biological Processnegative regulation of exocytosis
Biological Processnegative regulation of interleukin-8 production
Biological Processnegative regulation of T-helper 2 cell differentiation
Biological Processneutrophil activation
Biological Processneutrophil clearance
Biological Processpositive regulation of cell migration involved in sprouting angiogenesis
Biological Processpositive regulation of interleukin-2 production
Biological Processpositive regulation of T cell proliferation
Biological Processpositive regulation of T-helper 1 cell differentiation
Biological Processpositive regulation of vesicle fusion
Biological Processpositive regulation of wound healing
Biological Processregulation of cell shape
Biological Processregulation of hormone secretion

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Annexin

Gene names

    • Name
      Anxa1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q4FJV4

Organism-specific databases

Subcellular Location

Apical cell membrane
Basolateral cell membrane
Cell membrane
; Peripheral membrane protein
Cell projection, cilium
Cell projection, phagocytic cup
Cytoplasmic vesicle membrane
; Peripheral membrane protein
Early endosome
Endosome membrane
; Peripheral membrane protein
Lateral cell membrane
Membrane
; Peripheral membrane protein
Nucleus
Secreted, extracellular exosome
Secreted, extracellular space

Keywords

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Structure

Family & Domains

Domain

The full-length protein can bind eight Ca2+ ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca2+, these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.

Sequence similarities

Belongs to the annexin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    346
  • Mass (Da)
    38,734
  • Last updated
    2005-08-30 v1
  • Checksum
    9393A11B24191D3C
MAMVSEFLKQARFLENQEQEYVQAVKSYKGGPGSAVSPYPSFNVSSDVAALHKAIMVKGVDEATIIDILTKRTNAQRQQIKAAYLQENGKPLDEVLRKALTGHLEEVVLAMLKTPAQFDADELRGAMKGLGTDEDTLIEILTTRSNEQIREINRVYREELKRDLAKDITSDTSGDFRKALLALAKGDRCQDLSVNQDLADTDARALYEAGERRKGTDVNVFTTILTSRSFPHLRRVFQNYGKYSQHDMNKALDLELKGDIEKCLTTIVKCATSTPAFFAEKLYEAMKGAGTRHKALIRIMVSRSEIDMNEIKVFYQKKYGISLCQAILDETKGDYEKILVALCGGN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK150564
EMBL· GenBank· DDBJ
BAE29662.1
EMBL· GenBank· DDBJ
mRNA
AK150718
EMBL· GenBank· DDBJ
BAE29796.1
EMBL· GenBank· DDBJ
mRNA
AK153156
EMBL· GenBank· DDBJ
BAE31766.1
EMBL· GenBank· DDBJ
mRNA
AK167612
EMBL· GenBank· DDBJ
BAE39665.1
EMBL· GenBank· DDBJ
mRNA
CT010298
EMBL· GenBank· DDBJ
CAJ18506.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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