Q4F387 · Q4F387_HUMAN

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COX1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COX1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • MTDNA560
    • AF16
    • L322
    • L0a-1-01
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q4F387

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane18-37Helical
Transmembrane57-83Helical
Transmembrane104-128Helical
Transmembrane148-171Helical
Transmembrane183-210Helical
Transmembrane243-261Helical
Transmembrane268-291Helical
Transmembrane303-325Helical
Transmembrane337-359Helical
Transmembrane379-400Helical
Transmembrane412-430Helical
Transmembrane450-473Helical

Keywords

PTM/Processing

Proteomic databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-511Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    513
  • Mass (Da)
    57,039
  • Last updated
    2005-08-30 v1
  • Checksum
    13CAE32BEBE673B6
MFVDRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFAIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEPVYMKS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ112777
EMBL· GenBank· DDBJ
AAZ00971.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ304897
EMBL· GenBank· DDBJ
ABB97557.1
EMBL· GenBank· DDBJ
Genomic DNA
EF657743
EMBL· GenBank· DDBJ
ABR99618.1
EMBL· GenBank· DDBJ
Genomic DNA
EU092688
EMBL· GenBank· DDBJ
ABU64370.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ702326
EMBL· GenBank· DDBJ
AFF68198.1
EMBL· GenBank· DDBJ
Genomic DNA
KC622077
EMBL· GenBank· DDBJ
AGJ95475.1
EMBL· GenBank· DDBJ
Genomic DNA
KC533498
EMBL· GenBank· DDBJ
AGK64714.1
EMBL· GenBank· DDBJ
Genomic DNA
KF450901
EMBL· GenBank· DDBJ
AGZ65348.1
EMBL· GenBank· DDBJ
Genomic DNA
KF672806
EMBL· GenBank· DDBJ
AHA47512.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ185398
EMBL· GenBank· DDBJ
AID07585.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ669114
EMBL· GenBank· DDBJ
AIG60280.1
EMBL· GenBank· DDBJ
Genomic DNA
KM101662
EMBL· GenBank· DDBJ
AIU58307.1
EMBL· GenBank· DDBJ
Genomic DNA
KP635239
EMBL· GenBank· DDBJ
AKK32058.1
EMBL· GenBank· DDBJ
Genomic DNA
MF055775
EMBL· GenBank· DDBJ
ASR94002.1
EMBL· GenBank· DDBJ
Genomic DNA
MF621130
EMBL· GenBank· DDBJ
ATP05685.1
EMBL· GenBank· DDBJ
Genomic DNA
MF381287
EMBL· GenBank· DDBJ
AUR39873.1
EMBL· GenBank· DDBJ
Genomic DNA
MF695865
EMBL· GenBank· DDBJ
AUT77357.1
EMBL· GenBank· DDBJ
Genomic DNA
MH981602
EMBL· GenBank· DDBJ
AYV90032.1
EMBL· GenBank· DDBJ
Genomic DNA
MK248295
EMBL· GenBank· DDBJ
QFV14618.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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