Q4EWN6 · Q4EWN6_HUMAN

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COX1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processoxidative phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COX1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • AM17
    • AS47
    • L386
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q4EWN6

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane18-37Helical
Transmembrane57-83Helical
Transmembrane104-128Helical
Transmembrane148-171Helical
Transmembrane183-210Helical
Transmembrane243-261Helical
Transmembrane268-291Helical
Transmembrane303-325Helical
Transmembrane337-359Helical
Transmembrane379-400Helical
Transmembrane412-430Helical
Transmembrane450-473Helical

Keywords

PTM/Processing

Proteomic databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-511Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    513
  • Mass (Da)
    57,071
  • Last updated
    2005-08-30 v1
  • Checksum
    45BBFE808650A82D
MFTDRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEPVYMKS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ112832
EMBL· GenBank· DDBJ
AAZ01686.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ112954
EMBL· GenBank· DDBJ
AAZ03272.1
EMBL· GenBank· DDBJ
Genomic DNA
EU092750
EMBL· GenBank· DDBJ
ABU65171.1
EMBL· GenBank· DDBJ
Genomic DNA
GQ398480
EMBL· GenBank· DDBJ
ACT88836.1
EMBL· GenBank· DDBJ
Genomic DNA
GQ398481
EMBL· GenBank· DDBJ
ACT88849.1
EMBL· GenBank· DDBJ
Genomic DNA
GQ398482
EMBL· GenBank· DDBJ
ACT88862.1
EMBL· GenBank· DDBJ
Genomic DNA
GQ398483
EMBL· GenBank· DDBJ
ACT88875.1
EMBL· GenBank· DDBJ
Genomic DNA
GQ398484
EMBL· GenBank· DDBJ
ACT88888.1
EMBL· GenBank· DDBJ
Genomic DNA
GQ398485
EMBL· GenBank· DDBJ
ACT88901.1
EMBL· GenBank· DDBJ
Genomic DNA
GQ398486
EMBL· GenBank· DDBJ
ACT88914.1
EMBL· GenBank· DDBJ
Genomic DNA
GQ398487
EMBL· GenBank· DDBJ
ACT88927.1
EMBL· GenBank· DDBJ
Genomic DNA
GQ398488
EMBL· GenBank· DDBJ
ACT88940.1
EMBL· GenBank· DDBJ
Genomic DNA
GQ398489
EMBL· GenBank· DDBJ
ACT88953.1
EMBL· GenBank· DDBJ
Genomic DNA
GQ398490
EMBL· GenBank· DDBJ
ACT88966.1
EMBL· GenBank· DDBJ
Genomic DNA
JF824897
EMBL· GenBank· DDBJ
AEG63211.1
EMBL· GenBank· DDBJ
Genomic DNA
JF824990
EMBL· GenBank· DDBJ
AEG64420.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ703164
EMBL· GenBank· DDBJ
AFF79092.1
EMBL· GenBank· DDBJ
Genomic DNA
JX273267
EMBL· GenBank· DDBJ
AFP91508.1
EMBL· GenBank· DDBJ
Genomic DNA
KP317055
EMBL· GenBank· DDBJ
AJT36321.1
EMBL· GenBank· DDBJ
Genomic DNA
MF695933
EMBL· GenBank· DDBJ
AUT78240.1
EMBL· GenBank· DDBJ
Genomic DNA
MF437139
EMBL· GenBank· DDBJ
QBZ75043.1
EMBL· GenBank· DDBJ
Genomic DNA
MF437276
EMBL· GenBank· DDBJ
QBZ76824.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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