Q4EWN6 · Q4EWN6_HUMAN
- ProteinCytochrome c oxidase subunit 1
- GeneCOX1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids513 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)This reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Protein has several cofactor binding sites:
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | oxidative phosphorylation |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ4EWN6
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 18-37 | Helical | |||
Transmembrane | 57-83 | Helical | |||
Transmembrane | 104-128 | Helical | |||
Transmembrane | 148-171 | Helical | |||
Transmembrane | 183-210 | Helical | |||
Transmembrane | 243-261 | Helical | |||
Transmembrane | 268-291 | Helical | |||
Transmembrane | 303-325 | Helical | |||
Transmembrane | 337-359 | Helical | |||
Transmembrane | 379-400 | Helical | |||
Transmembrane | 412-430 | Helical | |||
Transmembrane | 450-473 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length513
- Mass (Da)57,071
- Last updated2005-08-30 v1
- Checksum45BBFE808650A82D
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DQ112832 EMBL· GenBank· DDBJ | AAZ01686.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ112954 EMBL· GenBank· DDBJ | AAZ03272.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU092750 EMBL· GenBank· DDBJ | ABU65171.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ398480 EMBL· GenBank· DDBJ | ACT88836.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ398481 EMBL· GenBank· DDBJ | ACT88849.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ398482 EMBL· GenBank· DDBJ | ACT88862.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ398483 EMBL· GenBank· DDBJ | ACT88875.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ398484 EMBL· GenBank· DDBJ | ACT88888.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ398485 EMBL· GenBank· DDBJ | ACT88901.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ398486 EMBL· GenBank· DDBJ | ACT88914.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ398487 EMBL· GenBank· DDBJ | ACT88927.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ398488 EMBL· GenBank· DDBJ | ACT88940.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ398489 EMBL· GenBank· DDBJ | ACT88953.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ398490 EMBL· GenBank· DDBJ | ACT88966.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JF824897 EMBL· GenBank· DDBJ | AEG63211.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JF824990 EMBL· GenBank· DDBJ | AEG64420.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ703164 EMBL· GenBank· DDBJ | AFF79092.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX273267 EMBL· GenBank· DDBJ | AFP91508.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP317055 EMBL· GenBank· DDBJ | AJT36321.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF695933 EMBL· GenBank· DDBJ | AUT78240.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF437139 EMBL· GenBank· DDBJ | QBZ75043.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF437276 EMBL· GenBank· DDBJ | QBZ76824.1 EMBL· GenBank· DDBJ | Genomic DNA |