Q4AEH8 · GPX2_MACFU

Function

function

Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis. Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides. Cannot reduce phosphatidycholine hydroperoxide.

Catalytic activity

  • 2 glutathione + H2O2 = glutathione disulfide + 2 H2O
    This reaction proceeds in the forward direction.
    EC:1.11.1.9 (UniProtKB | ENZYME | Rhea)
  • a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O
    This reaction proceeds in the forward direction.
    EC:1.11.1.12 (UniProtKB | ENZYME | Rhea)
  • 2 glutathione + tert-butyl hydroperoxide = glutathione disulfide + H2O + tert-butanol
    This reaction proceeds in the forward direction.
  • cumene hydroperoxide + 2 glutathione = 2-phenylpropan-2-ol + glutathione disulfide + H2O
    This reaction proceeds in the forward direction.
  • (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O
    This reaction proceeds in the forward direction.
  • (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
    This reaction proceeds in the forward direction.
  • (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O
    This reaction proceeds in the forward direction.
  • (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
    This reaction proceeds in the forward direction.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site40

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionglutathione peroxidase activity
Molecular Functionphospholipid-hydroperoxide glutathione peroxidase activity
Biological Processresponse to oxidative stress

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Glutathione peroxidase 2
  • EC number
  • Short names
    GPx-2; GSHPx-2
  • Alternative names
    • Glutathione peroxidase-gastrointestinal (GPx-GI; GSHPx-GI)
    • Phospholipid hydroperoxide glutathione peroxidase GPX2 (EC:1.11.1.12
      ) . EC:1.11.1.12 (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      GPX2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca

Accessions

  • Primary accession
    Q4AEH8

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000666211-190Glutathione peroxidase 2

Expression

Tissue specificity

Exclusively expressed in the stomach and small intestine.

Interaction

Subunit

Homotetramer.

Family & Domains

Sequence similarities

Belongs to the glutathione peroxidase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    190
  • Mass (Da)
    21,970
  • Last updated
    2008-02-26 v2
  • Checksum
    E63C54D365DF83B1
MAFIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLUGTTTRDFTQLNELQCRFPRRLVVLGFPCNQFGHQENCQNEEILNSLKYVRPGGGYQPTFTLVQKCEVNGQNEHPVFAYLKDKLPYPHDDPFSLMTDPKLIIWSPVRRSDVAWNFEKFLIGPEVEPFRRYSRTFPTINIEPDIKRLLKVAI

Features

Showing features for non-standard residue.

TypeIDPosition(s)Description
Non-standard residue40Selenocysteine

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB121003
EMBL· GenBank· DDBJ
BAE17012.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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