Q4ACW4 · CD1D_PANTR

Function

function

Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.

Features

Showing features for binding site.

133550100150200250300
TypeIDPosition(s)Description
Binding site98a D-galactosylceramide (UniProtKB | ChEBI)
Binding site169a D-galactosylceramide (UniProtKB | ChEBI)
Binding site169-172a D-galactosylceramide (UniProtKB | ChEBI)
Binding site172a D-galactosylceramide (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentbasolateral plasma membrane
Cellular Componentendoplasmic reticulum membrane
Cellular Componentendosome membrane
Cellular Componentexternal side of plasma membrane
Cellular Componentextracellular space
Cellular Componentlysosomal membrane
Cellular Componentlysosome
Molecular Functionendogenous lipid antigen binding
Molecular Functionexogenous lipid antigen binding
Molecular Functionlipid antigen binding
Molecular Functionlipopeptide binding
Biological Processantigen processing and presentation, endogenous lipid antigen via MHC class Ib
Biological Processantigen processing and presentation, exogenous lipid antigen via MHC class Ib
Biological Processimmune response
Biological Processinnate immune response
Biological Processpositive regulation of T cell mediated cytotoxicity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Antigen-presenting glycoprotein CD1d
  • CD Antigen Name
    • CD1d

Gene names

    • Name
      CD1D

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan

Accessions

  • Primary accession
    Q4ACW4
  • Secondary accessions
    • Q4ACU8

Proteomes

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Basolateral cell membrane
; Single-pass type I membrane protein
Endosome membrane
; Single-pass type I membrane protein
Lysosome membrane
; Single-pass type I membrane protein
Endoplasmic reticulum membrane
; Single-pass type I membrane protein
Note: Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain20-301Extracellular
Transmembrane302-322Helical
Topological domain323-335Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-19
ChainPRO_000004222020-335Antigen-presenting glycoprotein CD1d
Glycosylation38N-linked (GlcNAc...) asparagine
Glycosylation60N-linked (GlcNAc...) asparagine
Glycosylation126N-linked (GlcNAc...) asparagine
Glycosylation181N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Heterodimer with B2M (beta-2-microglobulin). Interacts with MHC II (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, motif.

TypeIDPosition(s)Description
Domain185-292Ig-like
Motif331-334Internalization signal

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    335
  • Mass (Da)
    37,758
  • Last updated
    2005-09-13 v1
  • Checksum
    2F90B2741110001D
MGCLLFLLLWALLQAWGSAEVPQRLFPLRCLQISSFANSSWTRTDGLAWLGELQTHSWSNDSDTVRSLKPWSQGTFSDQQWETLQHIFRVYRSSFTRDVKEFAKMLRLSYPLELQVSAGCEVHPGNASNNFFHVAFQGKDILSFQGTSWEPTQEAPLWVNLAIQVLNQDKWTRETVQWLLNGTCPQFVSGLLESGKSELEKQVKPKAWLSRGPSPGPGRLLLVCHVSGFYPKPVWVKWMRGEQEQQDTQPGDILPNADETWYLRATLDVAAGEAAGLSCRVKHSSLEGQDIILYWGGSYTSVGLIVLAVLACLLFLLIVGFTSRFKRQTSYQGVL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB222997
EMBL· GenBank· DDBJ
BAE16552.2
EMBL· GenBank· DDBJ
Genomic DNA
AB222998
EMBL· GenBank· DDBJ
BAE16553.1
EMBL· GenBank· DDBJ
Genomic DNA
AB223044
EMBL· GenBank· DDBJ
BAE16753.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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