Q49YT9 · DPO4_STAS1

Function

function

Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 magnesium ions per subunit.

Features

Showing features for binding site, site, active site.

TypeIDPosition(s)Description
Binding site10Mg2+ (UniProtKB | ChEBI)
Site15Substrate discrimination
Binding site105Mg2+ (UniProtKB | ChEBI)
Active site106

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functiondamaged DNA binding
Molecular FunctionDNA-directed DNA polymerase activity
Molecular Functionmagnesium ion binding
Biological ProcessDNA-templated DNA replication
Biological Processerror-prone translesion synthesis
Biological ProcessSOS response

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA polymerase IV
  • EC number
  • Short names
    Pol IV

Gene names

    • Name
      dinB
    • Ordered locus names
      SSP0896

Organism names

Accessions

  • Primary accession
    Q49YT9

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001739521-356DNA polymerase IV

Interaction

Subunit

Monomer.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-187UmuC

Sequence similarities

Belongs to the DNA polymerase type-Y family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    356
  • Mass (Da)
    40,416
  • Last updated
    2005-09-13 v1
  • Checksum
    7C5D07DE841460B5
MSERRIIHVDMDYFFAQVEMRDNPKLKGKPVIVGGKASGRGVVSTASYEARQYGVHSAMPTAQAHKLCPNGYYVTPRFEAYKTASEKIMNIFKSYTEVVEPLSLDEAYLDITHLVRPDLPASRIAQYIRRDIYEATMLTSSAGVSYNKFLAKLASGMNKPNGLTVIDYRNVHDILMGLDIGDFPGVGKASKQKMHQEAIYTGQDLYNQSERDLIRLFGKRGHGLYNKARGIDHNPVKPTRIRKSVGTERTFATDMNDDEEILQKIWELSNKTAERLAKLQKSGKTVTVKIKTFKFESLSKQRSLRDPVRSETDIYNIAYDLYTELKNPETPIRLVGVTVGNLEKATYENMTIYDYI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP008934
EMBL· GenBank· DDBJ
BAE18041.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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