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Q49MI3 · CERKL_HUMAN

  • Protein
    Ceramide kinase-like protein
  • Gene
    CERKL
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum
Cellular ComponentGolgi apparatus
Cellular Componentnucleolus
Cellular Componentnucleoplasm
Cellular Componentperinuclear region of cytoplasm
Cellular Componentphotoreceptor inner segment
Cellular Componentphotoreceptor outer segment
Molecular Functionlipid kinase activity
Molecular Functionsphingolipid binding
Biological Processnegative regulation of apoptotic process
Biological Processsphingolipid biosynthetic process
Biological Processsphingolipid metabolic process

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ceramide kinase-like protein

Gene names

    • Name
      CERKL

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q49MI3
  • Secondary accessions
    • B2RPL2
    • B4DEY1
    • Q49MH9
    • Q49MI0
    • Q49MI1

Proteomes

Organism-specific databases

Disease & Variants

Involvement in disease

Retinitis pigmentosa 26 (RP26)

  • Note
    • The disease is caused by variants affecting the gene represented in this entry
  • Description
    A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
  • See also
    MIM:608380
Natural variants in RP26
Variant IDPosition(s)ChangeDescription
VAR_065182106R>Sin RP26; dbSNP:rs569826109

Features

Showing features for mutagenesis, natural variant.

Type
IDPosition(s)Description
Mutagenesis104-106Only cytoplasmic.
Natural variantVAR_065182106in RP26; dbSNP:rs569826109
Natural variantVAR_053688232in dbSNP:rs10185262
Mutagenesis260Loss of nuclear localization; in isoform 2.
Natural variantVAR_053689514in dbSNP:rs35955809

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 195 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001813561-558Ceramide kinase-like protein

Post-translational modification

Phosphorylated on serine residues.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Isoform 1 and isoform 2 are expressed in adult retina, liver and pancreas as well as in fetal brain, lung and kidney. Isoform 3 is expressed in adult retina as well as in fetal lung and liver. Isoform 4 is expressed in adult retina, lung and kidney as well as in fetal lung and liver. Moderately expressed in retina, kidney, lung, testis, trachea, and pancreas. Weakly expressed in brain, placenta and liver.

Developmental stage

Expressed in fetal lung, kidney and brain.

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntAct
BINARY Q49MI3PPM1A P358133EBI-25586026, EBI-989143

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, motif, compositional bias, domain.

Type
IDPosition(s)Description
Region1-36Disordered
Motif2-9Nuclear localization signal 1
Compositional bias7-21Basic and acidic residues
Motif102-106Nuclear localization signal 2
Domain164-339DAGKc

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (8)
  • Sequence status
    Complete

This entry describes 8 isoforms produced by Alternative splicing.

Q49MI3-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    b
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    558
  • Mass (Da)
    62,622
  • Last updated
    2005-09-13 v1
  • MD5 Checksum
    26E6E2C829B87BE063E434D33289484E
MPWRRRRNRVSALEGGREEEAPPEAAAVPPALLTSPQQTEAAAERILLRGIFEIGRDSCDVVLSERALRWRPIQPERPAGDSKYDLLCKEEFIELKDIFSVKLKRRCSVKQQRSGTLLGITLFICLKKEQNKLKNSTLDLINLSEDHCDIWFRQFKKILAGFPNRPKSLKILLNPQSHKKEATQVYYEKVEPLLKLAGIKTDVTIMEYEGHALSLLKECELQGFDGGHRKPLFAIHWSVQRLFTGMQTLEPSVVCVGGDGSASEVAHALLLRAQKNAGMETDRILTPVRAQLPLGLIPAGSTNVLAHSLHGVPHVITATLHIIMGHVQLVDVCTFSTAGKLLRFGFSAMFGFGGRTLALAEKYRWMSPNQRRDFAVVKALAKLKAEDCEISFLPFNSSDDVQERRAQGSPKSDCNDQWQMIQGQFLNVSIMAIPCLCSVAPRGLAPNTRLNNGSMALIIARNTSRPEFIKHLKRYASVKNQFNFPFVETYTVEEVKVHPRNNTGGYNPEEEEDETASENCFPWNVDGDLMEVASEVHIRLHPRLISLYGGSMEEMIPK

Q49MI3-2

  • Name
    2
  • Synonyms
    a
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q49MI3-3

  • Name
    3
  • Synonyms
    d
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 205-300: IMEYEGHALSLLKECELQGFDGGHRKPLFAIHWSVQRLFTGMQTLEPSVVCVGGDGSASEVAHALLLRAQKNAGMETDRILTPVRAQLPLGLIPAG → R

Q49MI3-4

  • Name
    4
  • Synonyms
    c
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q49MI3-5

  • Name
    5
  • Note
    May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q49MI3-7

  • Name
    7
  • Synonyms
    f
  • Note
    May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q49MI3-8

  • Name
    8
  • Synonyms
    e
  • Note
    May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q49MI3-9

  • Name
    9
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 161-205: GFPNRPKSLKILLNPQSHKKEATQVYYEKVEPLLKLAGIKTDVTI → V

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A804HIX5A0A804HIX5_HUMANCERKL240
G0XYE7G0XYE7_HUMANCERKL280

Sequence caution

The sequence BAC85266.1 differs from that shown. Reason: Erroneous translation Wrong choice of CDS.
The sequence CAG26980.1 differs from that shown. Reason: Frameshift

Features

Showing features for compositional bias, sequence conflict, alternative sequence.

Type
IDPosition(s)Description
Compositional bias7-21Basic and acidic residues
Sequence conflict129in Ref. 2; CAG26980
Alternative sequenceVSP_016653160-298in isoform 4
Alternative sequenceVSP_016654161-173in isoform 8
Alternative sequenceVSP_042663161-205in isoform 9
Alternative sequenceVSP_016655174-558in isoform 8
Sequence conflict178in Ref. 2; CAG26978
Alternative sequenceVSP_016657205-217in isoform 7
Alternative sequenceVSP_016656205-300in isoform 3
Sequence conflict210in Ref. 2; CAG26977
Alternative sequenceVSP_016658218-558in isoform 7
Alternative sequenceVSP_016659227-252in isoform 2 and isoform 5
Alternative sequenceVSP_016660405-558in isoform 5

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY357073
EMBL· GenBank· DDBJ
AAR13670.1
EMBL· GenBank· DDBJ
mRNA
AY690329
EMBL· GenBank· DDBJ
AAW47988.1
EMBL· GenBank· DDBJ
mRNA
AY690330
EMBL· GenBank· DDBJ
AAW47989.1
EMBL· GenBank· DDBJ
mRNA
AY690331
EMBL· GenBank· DDBJ
AAW47990.1
EMBL· GenBank· DDBJ
mRNA
AY690332
EMBL· GenBank· DDBJ
AAW47991.1
EMBL· GenBank· DDBJ
mRNA
AY690333
EMBL· GenBank· DDBJ
AAW47992.1
EMBL· GenBank· DDBJ
mRNA
AJ640141
EMBL· GenBank· DDBJ
CAG26695.1
EMBL· GenBank· DDBJ
mRNA
AJ697855
EMBL· GenBank· DDBJ
CAG26977.1
EMBL· GenBank· DDBJ
mRNA
AJ697856
EMBL· GenBank· DDBJ
CAG26978.1
EMBL· GenBank· DDBJ
mRNA
AJ697858
EMBL· GenBank· DDBJ
CAG26980.1
EMBL· GenBank· DDBJ
mRNA Frameshift
AK129976
EMBL· GenBank· DDBJ
BAC85266.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
AK293844
EMBL· GenBank· DDBJ
BAG57242.1
EMBL· GenBank· DDBJ
mRNA
AC013733
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC020595
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC137498
EMBL· GenBank· DDBJ
AAI37499.1
EMBL· GenBank· DDBJ
mRNA
BC137499
EMBL· GenBank· DDBJ
AAI37500.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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