The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project TeamView abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]TissueBrainCategoriesSequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCGenome Res. 14:2121-2127 (2004)Cited in99+99+
E3 ubiquitin ligase UBR5 promotes gemcitabine resistance in pancreatic cancer by inducing O-GlcNAcylation-mediated EMT via destabilization of OGA.Du Y., Yang Z., Shi H., Chen Z., Chen R., Zhou F., Peng X., Hong T., Jiang L.View abstractAnnotationE3 ubiquitin ligase UBR5 promotes gemcitabine resistance in pancreatic cancer by inducing O-GlcNAcylation-mediated EMT via destabilization of OGA.SourceGeneRif: 51366PubMedEurope PMCCell Death Dis 15:340-340 (2024)Mapped to7
The role of UBR5 in tumor proliferation and oncotherapy.Hu B., Chen S.View abstractAnnotationThe role of UBR5 in tumor proliferation and oncotherapy.SourceGeneRif: 51366PubMedEurope PMCGene 906:148258-148258 (2024)Mapped to4
Spermatid perinuclear RNA-binding protein promotes UBR5-mediated proteolysis of Dicer to accelerate triple-negative breast cancer progression.Chen S.Y., Zhang F.L., Zhang Y.L., Liao L., Deng L., Shao Z.M., Liu G.Y., Li D.Q.View abstractAnnotationSpermatid perinuclear RNA-binding protein promotes UBR5-mediated proteolysis of Dicer to accelerate triple-negative breast cancer progression.SourceGeneRif: 51366PubMedEurope PMCCancer Lett 586:216672-216672 (2024)Mapped to15
Targeting UBR5 inhibits postsurgical breast cancer lung metastases by inducing CDC73 and p53 mediated apoptosis.Yu Z., Dong X., Song M., Xu A., He Q., Li H., Ouyang W., Chouchane L., Ma X.View abstractAnnotationTargeting UBR5 inhibits postsurgical breast cancer lung metastases by inducing CDC73 and p53 mediated apoptosis.SourceGeneRif: 51366PubMedEurope PMCInt J Cancer 154:723-737 (2024)Mapped to8
Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5.Hehl L.A., Horn-Ghetko D., Prabu J.R., Vollrath R., Vu D.T., Perez Berrocal D.A., Mulder M.P.C., van der Heden van Noort G.J., Schulman B.A.View abstractAnnotationStructural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5.SourceGeneRif: 51366PubMedEurope PMCNat. Chem. Biol. 20:190-200 (2024)Cited in1Mapped to4
Orphan quality control shapes network dynamics and gene expression.Mark K.G., Kolla S., Aguirre J.D., Garshott D.M., Schmitt S., Haakonsen D.L., Xu C., Kater L., Kempf G.[...], Rape M.View abstractAnnotationOrphan quality control shapes network dynamics and gene expression.SourceGeneRif: 51366PubMedEurope PMCCell 186:3460-3475 (2023)Cited in6Mapped to62
UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.Tsai J.M., Aguirre J.D., Li Y.D., Brown J., Focht V., Kater L., Kempf G., Sandoval B., Schmitt S.[...], Ebert B.L.View abstractAnnotationUBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.SourceGeneRif: 51366PubMedEurope PMCMol. Cell 83:2753-2767 (2023)Cited in8Mapped to3
Cryo-EM structure of the chain-elongating E3 ubiquitin ligase UBR5.Hodakova Z., Grishkovskaya I., Brunner H.L., Bolhuis D.L., Belacic K., Schleiffer A., Kotisch H., Brown N.G., Haselbach D.View abstractAnnotationCryo-EM structure of the chain-elongating E3 ubiquitin ligase UBR5.SourceGeneRif: 51366PubMedEurope PMCEMBO J. 42:e113348-e113348 (2023)Cited in2Mapped to3
The role and molecular mechanism of metabolic reprogramming of colorectal cancer by UBR5 through PYK2 regulation of OXPHOS expression study.Qin R., Huang Y., Yao Y., Wang L., Zhang Z., Huang W., Su Y., Zhang Y., Guan A., Wang H.View abstractAnnotationThe role and molecular mechanism of metabolic reprogramming of colorectal cancer by UBR5 through PYK2 regulation of OXPHOS expression study.SourceGeneRif: 51366PubMedEurope PMCJ Biochem Mol Toxicol 37:e23376-e23376 (2023)Mapped to7
Structure of the human UBR5 E3 ubiquitin ligase.Wang F., He Q., Zhan W., Yu Z., Finkin-Groner E., Ma X., Lin G., Li H.View abstractAnnotationStructure of the human UBR5 E3 ubiquitin ligase.CategoriesFamily & Domains, Interaction, StructureSourceGeneRif: 51366PubMedEurope PMCStructure 31:541-552 (2023)Cited in1Mapped to3
Clinicopathological Features and Prognostic Evaluation of UBR5 in Liver Cancer Patients.Huo Q., Hu J., Hou B., Zhao M., Han X., Du Y., Li Y.View abstractAnnotationClinicopathological Features and Prognostic Evaluation of UBR5 in Liver Cancer Patients.CategoriesNames, ExpressionSourceGeneRif: 51366PubMedEurope PMCPathol Oncol Res 28:1610396-1610396 (2022)Mapped to4
UBR5 promotes migration and invasion of glioma cells by regulating the ECRG4/NF-ҡB pathway.Wu Q., Liu L., Feng Y., Wang L., Liu X., Li Y.View abstractAnnotationUBR5 promotes migration and invasion of glioma cells by regulating the ECRG4/NF-B pathway.CategoriesFunction, ExpressionSourceGeneRif: 51366PubMedEurope PMCJ Biosci 47:45-45 (2022)Mapped to4
UBR5 promotes tumor immune evasion through enhancing IFN-gamma-induced pii>PDL1pi/i> transcription in triple negative breast cancer.Wu B., Song M., Dong Q., Xiang G., Li J., Ma X., Wei F.View abstractAnnotationUBR5 promotes tumor immune evasion through enhancing IFN-gamma-induced PDL1 transcription in triple negative breast cancer.CategoriesFunctionSourceGeneRif: 51366PubMedEurope PMCTheranostics 12:5086-5102 (2022)Mapped to4
UBR5 is a novel regulator of WNK1 stability.Jung J.U., B Ghosh A., Earnest S., Deaton S.L., Cobb M.H.View abstractAnnotationUBR5 is a novel regulator of WNK1 stability.CategoriesFunction, InteractionSourceGeneRif: 51366PubMedEurope PMCAm J Physiol Cell Physiol 322:C1176-C1186 (2022)Mapped to4
Role of ubiquitin-protein ligase UBR5 in the disassembly of mitotic checkpoint complexes.Kaisari S., Miniowitz-Shemtov S., Sitry-Shevah D., Shomer P., Kozlov G., Gehring K., Hershko A.View abstractAnnotationRole of ubiquitin-protein ligase UBR5 in the disassembly of mitotic checkpoint complexes.CategoriesPTM / Processing, InteractionSourceGeneRif: 51366PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 119:0-0 (2022)Cited in4Mapped to3
BoxCar and shotgun proteomic analyses reveal molecular networks regulated by UBR5 in prostate cancer.Yan Y., Zhou B., Lee Y.J., You S., Freeman M.R., Yang W.View abstractAnnotationBoxCar and shotgun proteomic analyses reveal molecular networks regulated by UBR5 in prostate cancer.CategoriesFunction, InteractionSourceGeneRif: 51366PubMedEurope PMCProteomics 22:e2100172-e2100172 (2022)Mapped to4
MicroRNA-361-5p slows down gliomas development through regulating UBR5 to elevate ATMIN protein expression.Jia J., Ouyang Z., Wang M., Ma W., Liu M., Zhang M., Yu M.View abstractAnnotationMicroRNA-361-5p slows down gliomas development through regulating UBR5 to elevate ATMIN protein expression.CategoriesFunction, ExpressionSourceGeneRif: 51366PubMedEurope PMCCell Death Dis 12:746-746 (2021)Mapped to7
UBR5 inhibits the radiosensitivity of non-small cell lung cancer cells via the activation of the PI3K/AKT pathway.Gu Y.F., Ge X.P.View abstractAnnotationUBR5 inhibits the radiosensitivity of non-small cell lung cancer cells via the activation of the PI3K/AKT pathway.CategoriesFunction, ExpressionSourceGeneRif: 51366PubMedEurope PMCJ Investig Med 69:970-975 (2021)Mapped to4
Combining UBR5 and CD163<sup>+</sup> tumor-associated macrophages better predicts prognosis of clear cell renal cell carcinoma patients.Wang C., Hong T., Wang Y., Peng G., Yu Y., Zhang J., Zhuo D., Zheng J., Ma X., Cui X.View abstractAnnotationCombining UBR5 and CD163(+) tumor-associated macrophages better predicts prognosis of clear cell renal cell carcinoma patients.CategoriesFunction, ExpressionSourceGeneRif: 51366PubMedEurope PMCCancer Immunol Immunother 70:2925-2935 (2021)Mapped to4
CSN6 promotes melanoma proliferation and metastasis by controlling the UBR5-mediated ubiquitination and degradation of CDK9.Zhang Y., Hou J., Shi S., Du J., Liu Y., Huang P., Li Q., Liu L., Hu H.[...], Cui H.View abstractAnnotationCSN6 promotes melanoma proliferation and metastasis by controlling the UBR5-mediated ubiquitination and degradation of CDK9.CategoriesFunction, InteractionSourceGeneRif: 51366PubMedEurope PMCCell Death Dis 12:118-118 (2021)Mapped to10
UBR7 functions with UBR5 in the Notch signaling pathway and is involved in a neurodevelopmental syndrome with epilepsy, ptosis, and hypothyroidism.Li C., Beauregard-Lacroix E., Kondratev C., Rousseau J., Heo A.J., Neas K., Graham B.H., Rosenfeld J.A., Bacino C.A.[...], Campeau P.M.View abstractAnnotationUBR7 functions with UBR5 in the Notch signaling pathway and is involved in a neurodevelopmental syndrome with epilepsy ptosis and hypothyroidism.CategoriesDisease & VariantsSourceGeneRif: 51366PubMedEurope PMCAm. J. Hum. Genet. 108:134-147 (2021)Cited in1Mapped to4
Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages.Song M., Yeku O.O., Rafiq S., Purdon T., Dong X., Zhu L., Zhang T., Wang H., Yu Z.[...], Ma X.View abstractAnnotationTumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages.CategoriesFunctionSourceGeneRif: 51366PubMedEurope PMCNat Commun 11:6298-6298 (2020)Mapped to9
E3 ubiquitin ligase UBR5 promotes pancreatic cancer growth and aerobic glycolysis by downregulating FBP1 via destabilization of C/EBPalpha.Chen L., Yuan R., Wen C., Liu T., Feng Q., Deng X., Du Y., Peng X.View abstractAnnotationE3 ubiquitin ligase UBR5 promotes pancreatic cancer growth and aerobic glycolysis by downregulating FBP1 via destabilization of C/EBPalpha.CategoriesFunctionSourceGeneRif: 51366PubMedEurope PMCOncogene 40:262-276 (2021)Mapped to4
The E3 ubiquitin ligase UBR5 interacts with TTC7A and may be associated with very early onset inflammatory bowel disease.Dhingani N., Guo C., Pan J., Li Q., Warner N., Jardine S., Leung G., Kotlarz D., Gonzaga-Jauregui C.[...], Muise A.M.View abstractAnnotationThe E3 ubiquitin ligase UBR5 interacts with TTC7A and may be associated with very early onset inflammatory bowel disease.CategoriesInteractionSourceGeneRif: 51366PubMedEurope PMCSci Rep 10:18648-18648 (2020)Mapped to9