Q497N6 · C295L_MOUSE
- ProteinCEP295 N-terminal-like protein
- GeneCep295nl
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids533 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | centriole | |
Cellular Component | centrosome | |
Cellular Component | cytosol | |
Cellular Component | motile cilium | |
Molecular Function | microtubule binding | |
Biological Process | regulation of centriole replication |
Names & Taxonomy
Protein names
- Recommended nameCEP295 N-terminal-like protein
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ497N6
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Colocalizes to the motile cilium of mature spermatozoa.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000422184 | 1-533 | CEP295 N-terminal-like protein | |||
Sequence: MQRDTERAAQLSPSSEDEALVLRQKPLEMPAQEEDSTTLQQWKARQLQRLAEELKAEWQEARLQQVRQAERLYLSHLLDEAAERSMGNDPSVHEQNQRRTAKHTRAKERNRAAFREERGRREEHPRQHPKSRKKAPCSERRSSAKARGPASGEKGKRRRVSSSKDHDGYQGPRVTRRVGVAKLNPFFDGDTDCMEDVQKEFFREGRRPSAKGTHNLRDQSLQGKTTALTQPLLHGPTCKQEAAAQEPPSKYNKNLWHKEIESTFEELFNMNRKLKKHLNLHLEQRLKADQNPDEQQSYSEIRSETFGTPREERTEEVETAEESGSPTEVETTEMWSKVNLKQILSDSEYPRYQQIAKYPLKSESLVPVKAGTSREQDDLLSLSPESGQEPPKSPLLEDESLKPYLQKQADSVASWMALRQKQKAELEQRRQKALLELTEHPNMSLEIHYKAELEEERRARRRMRLALLKSNSTGICALPPDRNNLSLDNGLLDEDKQNQMIRDLQQQILEQNKLHQEFLEKARKRLQEFQKSF |
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in mature spermatozoa (at protein level). Detected in retina, lung and kidney. In brain, highly expressed in brain-stem, cerebral cortex and thalamus with lesser expression in cerebellum and hippocampus.
Induction
Expression is moderately up-regulated 2 days after intracranial injury and increases at 4 and 7 days post-injury.
Developmental stage
Expressed during the postmeiotic stages of spermatogenesis. Detected at least at 14 dpc, the expression being enriched in kidney and small intestine. Within the nervous system, expression is prominent in the most superficial layers of the posterior cerebral cortex at 14 dpc and retina at 18 dpc. Expression is enriched in the posterior cerebral cortex at birth and declines at 7 days after birth.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, coiled coil, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-40 | Disordered | ||||
Sequence: MQRDTERAAQLSPSSEDEALVLRQKPLEMPAQEEDSTTLQ | ||||||
Coiled coil | 40-72 | |||||
Sequence: QQWKARQLQRLAEELKAEWQEARLQQVRQAERL | ||||||
Region | 84-176 | Disordered | ||||
Sequence: RSMGNDPSVHEQNQRRTAKHTRAKERNRAAFREERGRREEHPRQHPKSRKKAPCSERRSSAKARGPASGEKGKRRRVSSSKDHDGYQGPRVTR | ||||||
Compositional bias | 95-124 | Basic and acidic residues | ||||
Sequence: QNQRRTAKHTRAKERNRAAFREERGRREEH | ||||||
Compositional bias | 136-172 | Basic and acidic residues | ||||
Sequence: PCSERRSSAKARGPASGEKGKRRRVSSSKDHDGYQGP | ||||||
Region | 286-333 | Disordered | ||||
Sequence: LKADQNPDEQQSYSEIRSETFGTPREERTEEVETAEESGSPTEVETTE | ||||||
Compositional bias | 305-320 | Basic and acidic residues | ||||
Sequence: TFGTPREERTEEVETA | ||||||
Region | 370-399 | Disordered | ||||
Sequence: AGTSREQDDLLSLSPESGQEPPKSPLLEDE | ||||||
Coiled coil | 416-531 | |||||
Sequence: MALRQKQKAELEQRRQKALLELTEHPNMSLEIHYKAELEEERRARRRMRLALLKSNSTGICALPPDRNNLSLDNGLLDEDKQNQMIRDLQQQILEQNKLHQEFLEKARKRLQEFQK |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length533
- Mass (Da)61,957
- Last updated2005-09-13 v1
- ChecksumD5AE41B98F6F46EB
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A9L6KDE5 | A0A9L6KDE5_MOUSE | Cep295nl | 270 |
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 17 | in Ref. 1; CAA71005 | ||||
Sequence: D → N | ||||||
Sequence conflict | 85 | in Ref. 1; CAA71005 | ||||
Sequence: S → T | ||||||
Sequence conflict | 91 | in Ref. 1; CAA71005 | ||||
Sequence: S → R | ||||||
Compositional bias | 95-124 | Basic and acidic residues | ||||
Sequence: QNQRRTAKHTRAKERNRAAFREERGRREEH | ||||||
Compositional bias | 136-172 | Basic and acidic residues | ||||
Sequence: PCSERRSSAKARGPASGEKGKRRRVSSSKDHDGYQGP | ||||||
Compositional bias | 305-320 | Basic and acidic residues | ||||
Sequence: TFGTPREERTEEVETA |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Y09878 EMBL· GenBank· DDBJ | CAA71005.1 EMBL· GenBank· DDBJ | mRNA | ||
AK132657 EMBL· GenBank· DDBJ | BAE21285.1 EMBL· GenBank· DDBJ | mRNA | ||
AL591404 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC100451 EMBL· GenBank· DDBJ | AAI00452.1 EMBL· GenBank· DDBJ | mRNA |