Q497N6 · C295L_MOUSE

  • Protein
    CEP295 N-terminal-like protein
  • Gene
    Cep295nl
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcentriole
Cellular Componentcentrosome
Cellular Componentcytosol
Cellular Componentmotile cilium
Molecular Functionmicrotubule binding
Biological Processregulation of centriole replication

Names & Taxonomy

Protein names

  • Recommended name
    CEP295 N-terminal-like protein
  • Alternative names
    • Differential display clone 8
    • KIAA1731 N-terminal like protein

Gene names

    • Name
      Cep295nl
    • Synonyms
      Ddc8
      , Kiaa1731nl

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q497N6
  • Secondary accessions
    • P97320

Proteomes

Organism-specific databases

Subcellular Location

Note: Colocalizes to the motile cilium of mature spermatozoa.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004221841-533CEP295 N-terminal-like protein

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in mature spermatozoa (at protein level). Detected in retina, lung and kidney. In brain, highly expressed in brain-stem, cerebral cortex and thalamus with lesser expression in cerebellum and hippocampus.

Induction

Expression is moderately up-regulated 2 days after intracranial injury and increases at 4 and 7 days post-injury.

Developmental stage

Expressed during the postmeiotic stages of spermatogenesis. Detected at least at 14 dpc, the expression being enriched in kidney and small intestine. Within the nervous system, expression is prominent in the most superficial layers of the posterior cerebral cortex at 14 dpc and retina at 18 dpc. Expression is enriched in the posterior cerebral cortex at birth and declines at 7 days after birth.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, coiled coil, compositional bias.

TypeIDPosition(s)Description
Region1-40Disordered
Coiled coil40-72
Region84-176Disordered
Compositional bias95-124Basic and acidic residues
Compositional bias136-172Basic and acidic residues
Region286-333Disordered
Compositional bias305-320Basic and acidic residues
Region370-399Disordered
Coiled coil416-531

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    533
  • Mass (Da)
    61,957
  • Last updated
    2005-09-13 v1
  • Checksum
    D5AE41B98F6F46EB
MQRDTERAAQLSPSSEDEALVLRQKPLEMPAQEEDSTTLQQWKARQLQRLAEELKAEWQEARLQQVRQAERLYLSHLLDEAAERSMGNDPSVHEQNQRRTAKHTRAKERNRAAFREERGRREEHPRQHPKSRKKAPCSERRSSAKARGPASGEKGKRRRVSSSKDHDGYQGPRVTRRVGVAKLNPFFDGDTDCMEDVQKEFFREGRRPSAKGTHNLRDQSLQGKTTALTQPLLHGPTCKQEAAAQEPPSKYNKNLWHKEIESTFEELFNMNRKLKKHLNLHLEQRLKADQNPDEQQSYSEIRSETFGTPREERTEEVETAEESGSPTEVETTEMWSKVNLKQILSDSEYPRYQQIAKYPLKSESLVPVKAGTSREQDDLLSLSPESGQEPPKSPLLEDESLKPYLQKQADSVASWMALRQKQKAELEQRRQKALLELTEHPNMSLEIHYKAELEEERRARRRMRLALLKSNSTGICALPPDRNNLSLDNGLLDEDKQNQMIRDLQQQILEQNKLHQEFLEKARKRLQEFQKSF

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A9L6KDE5A0A9L6KDE5_MOUSECep295nl270

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict17in Ref. 1; CAA71005
Sequence conflict85in Ref. 1; CAA71005
Sequence conflict91in Ref. 1; CAA71005
Compositional bias95-124Basic and acidic residues
Compositional bias136-172Basic and acidic residues
Compositional bias305-320Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Y09878
EMBL· GenBank· DDBJ
CAA71005.1
EMBL· GenBank· DDBJ
mRNA
AK132657
EMBL· GenBank· DDBJ
BAE21285.1
EMBL· GenBank· DDBJ
mRNA
AL591404
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC100451
EMBL· GenBank· DDBJ
AAI00452.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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