Q49744 · RNZ_MYCLE

Function

function

Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity).

Caution

Could be the product of a pseudogene. This sequence is much shorter in its N-terminus than orthologs.
Lacks two conserved zinc binding sites.

Catalytic activity

  • Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.
    EC:3.1.26.11 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site38Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site40Zn2+ 1 (UniProtKB | ChEBI); catalytic
Active site42Proton acceptor
Binding site42Zn2+ 2 (UniProtKB | ChEBI); catalytic
Binding site130Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site215Zn2+ 2 (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Molecular Function3'-tRNA processing endoribonuclease activity
Molecular Functionmetal ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Putative ribonuclease Z
  • EC number
  • Short names
    RNase Z; tRNase Z
  • Alternative names
    • tRNA 3 endonuclease

Gene names

    • Name
      rnz
    • ORF names
      B1937_C1_163, MLCL536.01
    • Ordered locus names
      ML0608

Organism names

Accessions

  • Primary accession
    Q49744
  • Secondary accessions
    • O33130

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001558771-220Putative ribonuclease Z

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region193-220Disordered

Sequence similarities

Belongs to the RNase Z family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    220
  • Mass (Da)
    23,634
  • Last updated
    2004-01-16 v2
  • Checksum
    C3F0F9B5B2F3F92A
MQAGRQLFLVDCWLGVLQRASAGPTHTPAVCQRCCSTHLHGDRISDLGDLLITHWVTTFALDPPPLPIIGSPDTAETVEAKLKASGHDIEYQITHHTYLNTPPLIEVYEYTKGFVGAPPDGVSIRGSTNHGPVTPTIGFRIESGPTSVVLTGGTVPCASLDELAAEADALVHTIIRKNIVIRVHQQADQGHLQPPLVNRASDSNRGARGHRHPGHNVLCP

Sequence caution

The sequence AAA17148.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U00016
EMBL· GenBank· DDBJ
AAA17148.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation
Z99125
EMBL· GenBank· DDBJ
CAB16144.1
EMBL· GenBank· DDBJ
Genomic DNA
AL583919
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Similar Proteins

Disclaimer

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