In islets from type 2 diabetic mice the expression level of Olfr15 and the octanoic acid-induced enhancement of glucose-stimulated insulin secretion were strongly reduced.
These findings suggest that Olfr15 and Olfr821 in pancreatic beta-cells has a chemo-sensor function allowing recognition of environmental substances obtained from food and potentiates insulin secretion in a cell-autonomous manner thereby modulating systemic glucose metabolism.
homo- and heterotypic adhesion between cells overexpressing the ORs MOR256-17 or M71 supporting the hypothesis that ORs may contribute to olfactory axon sorting by mediating differential adhesion between axons.
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