Q49575 · A85B_MYCIA

Function

function

The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan and through the synthesis of alpha,alpha-trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) to another TMM, leading to the formation of TDM (By similarity).

Catalytic activity

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site82-83substrate
Active site166Nucleophile
Binding site166substrate
Binding site194substrate
Active site270
Binding site272-275substrate
Binding site279substrate
Active site302
Binding site302-304substrate

GO annotations

AspectTerm
Cellular Componentextracellular region
Molecular Functiondiacylglycerol O-acyltransferase activity
Molecular Functiontrehalose O-mycolyltransferase activity

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Diacylglycerol acyltransferase/mycolyltransferase Ag85B
  • EC number
  • Short names
    DGAT
  • Alternative names
    • 30 kDa extracellular protein
    • Acyl-CoA:diacylglycerol acyltransferase
    • Antigen 85 complex B (85B; Ag85B)
    • Extracellular alpha-antigen
    • Fibronectin-binding protein B (Fbps B)

Gene names

    • Name
      fbpB
    • Ordered locus names
      OCU_26350

Organism names

Accessions

  • Primary accession
    Q49575
  • Secondary accessions
    • H8IM05
    • P94938

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-40
ChainPRO_000000021841-330Diacylglycerol acyltransferase/mycolyltransferase Ag85B
Disulfide bond127↔132

Keywords

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region98-108Fibronectin-binding

Sequence similarities

Belongs to the mycobacterial A85 antigen family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    330
  • Mass (Da)
    34,522
  • Last updated
    2012-06-13 v2
  • Checksum
    76FDB684BF4E50D4
MTDLSEKVRAWGRRLVVGAAAAATLPGLIGIAGGAATANAFSRPGLPVEYLQVPSAGMGRDIKVQFQSGGNGSPAVYLLDGLRAQDDYNGWDINTPAFEWYYQSGLSVIMPVGGQSSFYADWYQPACGKAGCSTYKWETFLTSELPQYLASNKGVKSTGSAAVGISMSGSSAMILAVNHPNQFVYAGSLSALLDPSQGMGPSLIGLAMGDAGGYKADAMWGPSSDPAWQRNDPSLQIPALVGNNTRLWVYCGNGTPSELGGANMPAEFLENFVRSSNLKFQDAYNAAGGHNAVFNFNANGTHSWEYWGAQLNAMKPDLQSALGASSGGGG

Sequence caution

The sequence AFC43854.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict47-48in Ref. 1; BAA03243
Sequence conflict138in Ref. 1; BAA03243/BAA03981
Sequence conflict310in Ref. 1; BAA03243

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D16546
EMBL· GenBank· DDBJ
BAA03981.1
EMBL· GenBank· DDBJ
Genomic DNA
D14253
EMBL· GenBank· DDBJ
BAA03243.1
EMBL· GenBank· DDBJ
Genomic DNA
CP003322
EMBL· GenBank· DDBJ
AFC43854.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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