Q48CE0 · HUTU_PSE14
- ProteinUrocanate hydratase
- GenehutU
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids565 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
Catalytic activity
- 4-imidazolone-5-propanoate = H2O + trans-urocanate
Cofactor
Note: Binds 1 NAD+ per subunit.
Pathway
Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 61-62 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GG | ||||||
Binding site | 139 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 185-187 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GMG | ||||||
Binding site | 205 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 210 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 251-252 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: NA | ||||||
Binding site | 272-276 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: QTSAH | ||||||
Binding site | 282-283 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: YL | ||||||
Binding site | 331 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Active site | 419 | |||||
Sequence: C | ||||||
Binding site | 501 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: G |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | urocanate hydratase activity | |
Biological Process | L-histidine catabolic process to glutamate and formamide | |
Biological Process | L-histidine catabolic process to glutamate and formate |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUrocanate hydratase
- EC number
- Short namesUrocanase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas
Accessions
- Primary accessionQ48CE0
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000025138 | 1-565 | Urocanate hydratase | |||
Sequence: MTENNQDLKQNWTRHREGVVQAACGTQLTAKSWLTEAPLRMLMNNLDPEVAENPNELVVYGGIGRAARNWECYDKIVESLTQLNDDETLLVQSGKPVGVFKTHSNAPRVLIANSNLVPHWASWEHFNELDAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQHYDGNLKGRWVLTAGLGGMGGAQPLAATLAGACSLNIECQQSRIDFRIKTRYVDEQAADLDDALARIAKYTAEGKAISIALCGNAAEILPEMVRRGVRPDMVTDQTSAHDPLNGYLPKGWTWDEYRVRSVSEPANVVKAAKQSMAEHVEAMLAFQQAGIPTFDYGNNIRQMAKEVGVANAFDFPGFVPAYIRPLFCRGIGPFRWAALSGDPEDIYKTDAKVKELIPDDDHLHNWLDMARERISFQGLPARICWVGLGQRAKLGLAFNEMVRSGELSAPVVIGRDHLDSGSVASPNRETESMRDGSDAVSDWPLLNALLNTASGATWVSLHHGGGVGMGFSQHSGMVIVCDGTDEAAERIARVLHNDPATGVMRHADAGYDIAIDCAREQGLNLPMIGR |
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length565
- Mass (Da)61,760
- Last updated2005-09-13 v1
- ChecksumA94969B1B9C06C25
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000058 EMBL· GenBank· DDBJ | AAZ37644.1 EMBL· GenBank· DDBJ | Genomic DNA |