Q48CE0 · HUTU_PSE14

Function

function

Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.

Catalytic activity

Cofactor

NAD+ (UniProtKB | Rhea| CHEBI:57540 )

Note: Binds 1 NAD+ per subunit.

Pathway

Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site61-62NAD+ (UniProtKB | ChEBI)
Binding site139NAD+ (UniProtKB | ChEBI)
Binding site185-187NAD+ (UniProtKB | ChEBI)
Binding site205NAD+ (UniProtKB | ChEBI)
Binding site210NAD+ (UniProtKB | ChEBI)
Binding site251-252NAD+ (UniProtKB | ChEBI)
Binding site272-276NAD+ (UniProtKB | ChEBI)
Binding site282-283NAD+ (UniProtKB | ChEBI)
Binding site331NAD+ (UniProtKB | ChEBI)
Active site419
Binding site501NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionurocanate hydratase activity
Biological ProcessL-histidine catabolic process to glutamate and formamide
Biological ProcessL-histidine catabolic process to glutamate and formate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Urocanate hydratase
  • EC number
  • Short names
    Urocanase
  • Alternative names
    • Imidazolonepropionate hydrolase

Gene names

    • Name
      hutU
    • Ordered locus names
      PSPPH_4860

Organism names

Accessions

  • Primary accession
    Q48CE0

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000251381-565Urocanate hydratase

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region453-472Disordered

Sequence similarities

Belongs to the urocanase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    565
  • Mass (Da)
    61,760
  • Last updated
    2005-09-13 v1
  • Checksum
    A94969B1B9C06C25
MTENNQDLKQNWTRHREGVVQAACGTQLTAKSWLTEAPLRMLMNNLDPEVAENPNELVVYGGIGRAARNWECYDKIVESLTQLNDDETLLVQSGKPVGVFKTHSNAPRVLIANSNLVPHWASWEHFNELDAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQHYDGNLKGRWVLTAGLGGMGGAQPLAATLAGACSLNIECQQSRIDFRIKTRYVDEQAADLDDALARIAKYTAEGKAISIALCGNAAEILPEMVRRGVRPDMVTDQTSAHDPLNGYLPKGWTWDEYRVRSVSEPANVVKAAKQSMAEHVEAMLAFQQAGIPTFDYGNNIRQMAKEVGVANAFDFPGFVPAYIRPLFCRGIGPFRWAALSGDPEDIYKTDAKVKELIPDDDHLHNWLDMARERISFQGLPARICWVGLGQRAKLGLAFNEMVRSGELSAPVVIGRDHLDSGSVASPNRETESMRDGSDAVSDWPLLNALLNTASGATWVSLHHGGGVGMGFSQHSGMVIVCDGTDEAAERIARVLHNDPATGVMRHADAGYDIAIDCAREQGLNLPMIGR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000058
EMBL· GenBank· DDBJ
AAZ37644.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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