Q46FV0 · KAD6_METBF

Function

function

Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late maturation steps of the 30S ribosomal particles, specifically 16S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site10ATP (UniProtKB | ChEBI)
Binding site12ATP (UniProtKB | ChEBI)
Binding site13ATP (UniProtKB | ChEBI)
Binding site14ATP (UniProtKB | ChEBI)
Binding site15ATP (UniProtKB | ChEBI)
Binding site105ATP (UniProtKB | ChEBI)
Binding site143ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionadenylate kinase activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Biological Processribosomal small subunit biogenesis
Biological ProcessrRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Putative adenylate kinase
  • EC number
  • Short names
    AK
  • Alternative names
    • ATP-AMP transphosphorylase

Gene names

    • Ordered locus names
      Mbar_A0258

Organism names

Accessions

  • Primary accession
    Q46FV0

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000030911-182Putative adenylate kinase

Proteomic databases

Interaction

Subunit

Interacts with uS11. Not a structural component of 40S pre-ribosomes, but transiently interacts with them by binding to uS11.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region30-53NMP
Region104-114LID

Sequence similarities

Belongs to the adenylate kinase family. AK6 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    182
  • Mass (Da)
    21,069
  • Last updated
    2005-09-13 v1
  • Checksum
    6EE6678F65AE38CA
MLIGLTGTPGTGKTSVSKFLERKRHWKVIHLNEMIKEEHLYTEVDEVRDAVIADMELVRQRLEEIIGGKENEVIILESHLAHYIADIVIILRVYPPELKMRLKARGYSEEKIRENIEAEALDVILVEAFEWCKKVFEINTTGKSIEETEQHIEKIIDHILSGNEEELPEYKPGSIDWIDLVP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000099
EMBL· GenBank· DDBJ
AAZ69242.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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