Q46720 · Q46720_ECOLX

  • Protein
    GDP-L-fucose synthase
  • Gene
    wbdJ
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.

Features

Showing features for binding site, site, active site.

TypeIDPosition(s)Description
Binding site7-13NADP+ (UniProtKB | ChEBI)
Binding site101-104NADP+ (UniProtKB | ChEBI)
Site103Important for catalytic activity
Site105Important for catalytic activity
Active site132Proton donor/acceptor
Binding site136NADP+ (UniProtKB | ChEBI)
Binding site160-163NADP+ (UniProtKB | ChEBI)
Binding site176NADP+ (UniProtKB | ChEBI)
Binding site184substrate
Binding site199substrate
Binding site206substrate

GO annotations

AspectTerm
Molecular FunctionGDP-L-fucose synthase activity
Molecular Functionisomerase activity
Molecular FunctionNADP+ binding
Biological Process'de novo' GDP-L-fucose biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GDP-L-fucose synthase
  • EC number
  • Alternative names
    • GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase

Gene names

    • Name
      wbdJ
    • Synonyms
      fcl
    • ORF names
      NCTC8009_05293
      , NCTC8333_02244

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 18
    • 1074
    • 9662
    • 43887
    • Stoke W
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia

Accessions

  • Primary accession
    Q46720

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-235NAD-dependent epimerase/dehydratase

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    307
  • Mass (Da)
    34,751
  • Last updated
    1996-11-01 v1
  • Checksum
    16056E2D8348B289
MKVLLTGSTGMVGKNILEHDSASKYNILTPTSSDLNLLDKNEIEKFMLINMPDCIIHAAGLVGGIHANISRPFDFLEKNLQMGLNLVSVAKKLGIKKVLNLGSSCMYPKNFEEAIPEKALLTGELEETNEGYAIAKIAVAKACEYISRENSNYFYKTIIPCNLYGKYDKFDDNSSHMIPAVIKKIHHAKINNVPEIEIWGDGNSRREFMYAEDLADLIFYVIPKIEFMPNMVNAGLGYDYSINDYYKIIAEEIGYTGSFSHDLTKPTGMKRKLVDISLLNKIGWSSHFELRDGIRKTYNYYLENQNK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF078736
EMBL· GenBank· DDBJ
AAC44884.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887644
EMBL· GenBank· DDBJ
AFE83059.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887645
EMBL· GenBank· DDBJ
AFE83070.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887646
EMBL· GenBank· DDBJ
AFE83081.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887647
EMBL· GenBank· DDBJ
AFE83092.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887648
EMBL· GenBank· DDBJ
AFE83103.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887649
EMBL· GenBank· DDBJ
AFE83114.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887650
EMBL· GenBank· DDBJ
AFE83125.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887651
EMBL· GenBank· DDBJ
AFE83136.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887652
EMBL· GenBank· DDBJ
AFE83147.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887653
EMBL· GenBank· DDBJ
AFE83158.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887654
EMBL· GenBank· DDBJ
AFE83169.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887655
EMBL· GenBank· DDBJ
AFE83180.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887656
EMBL· GenBank· DDBJ
AFE83191.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887657
EMBL· GenBank· DDBJ
AFE83201.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887658
EMBL· GenBank· DDBJ
AFE83212.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887659
EMBL· GenBank· DDBJ
AFE83223.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887660
EMBL· GenBank· DDBJ
AFE83234.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887661
EMBL· GenBank· DDBJ
AFE83245.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887662
EMBL· GenBank· DDBJ
AFE83256.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887663
EMBL· GenBank· DDBJ
AFE83267.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887664
EMBL· GenBank· DDBJ
AFE83278.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887665
EMBL· GenBank· DDBJ
AFE83289.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887666
EMBL· GenBank· DDBJ
AFE83300.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887667
EMBL· GenBank· DDBJ
AFE83311.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887668
EMBL· GenBank· DDBJ
AFE83322.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887669
EMBL· GenBank· DDBJ
AFE83333.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887670
EMBL· GenBank· DDBJ
AFE83344.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887671
EMBL· GenBank· DDBJ
AFE83355.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887672
EMBL· GenBank· DDBJ
AFE83366.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887673
EMBL· GenBank· DDBJ
AFE83377.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887674
EMBL· GenBank· DDBJ
AFE83388.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887675
EMBL· GenBank· DDBJ
AFE83399.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887676
EMBL· GenBank· DDBJ
AFE83410.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887677
EMBL· GenBank· DDBJ
AFE83421.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887678
EMBL· GenBank· DDBJ
AFE83432.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887679
EMBL· GenBank· DDBJ
AFE83443.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887680
EMBL· GenBank· DDBJ
AFE83454.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887681
EMBL· GenBank· DDBJ
AFE83465.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887682
EMBL· GenBank· DDBJ
AFE83476.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887683
EMBL· GenBank· DDBJ
AFE83487.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887684
EMBL· GenBank· DDBJ
AFE83498.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887685
EMBL· GenBank· DDBJ
AFE83509.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887686
EMBL· GenBank· DDBJ
AFE83520.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887687
EMBL· GenBank· DDBJ
AFE83531.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887688
EMBL· GenBank· DDBJ
AFE83542.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887689
EMBL· GenBank· DDBJ
AFE83553.1
EMBL· GenBank· DDBJ
Genomic DNA
JN887690
EMBL· GenBank· DDBJ
AFE83564.1
EMBL· GenBank· DDBJ
Genomic DNA
UARW01000010
EMBL· GenBank· DDBJ
SQD04757.1
EMBL· GenBank· DDBJ
Genomic DNA
UGFE01000002
EMBL· GenBank· DDBJ
STM23320.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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