Q44977 · OSPC2_BORBG
- ProteinOuter surface protein C
- GeneospC
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids211 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
function
Major immunodominant protein in mammalian hosts. Required for initial stages of mammalian infection. Inhibits macrophage-mediated phagocytosis of the bacteria. Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue. Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo.
Miscellaneous
The causative agent of Lyme disease, the bacteria has an enzootic lifestyle. Larval ticks are infected with bacteria during feeding on infected hosts (mostly mammals) which retain the bacteria during subsequent developmental stages. It is transmitted to the next host when it is bitten by ticks. During tick feeding (which can last for several days), bacterial migrate from the tick midgut to the salivary gland where they are transmitted to the host.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cell outer membrane | |
Cellular Component | cell surface |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameOuter surface protein C
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Spirochaetota > Spirochaetia > Spirochaetales > Borreliaceae > Borreliella
Accessions
- Primary accessionQ44977
Subcellular Location
PTM/Processing
Features
Showing features for signal, lipidation, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-18 | ||||
Lipidation | 19 | N-palmitoyl cysteine | |||
Lipidation | 19 | S-diacylglycerol cysteine | |||
Chain | PRO_5007702823 | 19-211 | Outer surface protein C | ||
Keywords
- PTM
Interaction
Subunit
Homodimer (Probable). Interacts with tick I.ricinus salivary protein Iric-1, Iric-2 and Iric-3 (PubMed:33401196).
Binds human (host) plasminogen (By similarity).
Binds human (host) plasminogen (By similarity).
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length211
- Mass (Da)22,214
- Last updated1996-11-01 v1
- ChecksumBFE8C7820CDE10D3
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EF537412 EMBL· GenBank· DDBJ | ABQ42966.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X81522 EMBL· GenBank· DDBJ | CAA57242.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ749599 EMBL· GenBank· DDBJ | CAG44434.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ749602 EMBL· GenBank· DDBJ | CAG44437.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ749605 EMBL· GenBank· DDBJ | CAG44440.1 EMBL· GenBank· DDBJ | Genomic DNA |