Q44977 · OSPC2_BORBG

Function

function

Major immunodominant protein in mammalian hosts. Required for initial stages of mammalian infection. Inhibits macrophage-mediated phagocytosis of the bacteria. Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue. Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo.

Miscellaneous

The causative agent of Lyme disease, the bacteria has an enzootic lifestyle. Larval ticks are infected with bacteria during feeding on infected hosts (mostly mammals) which retain the bacteria during subsequent developmental stages. It is transmitted to the next host when it is bitten by ticks. During tick feeding (which can last for several days), bacterial migrate from the tick midgut to the salivary gland where they are transmitted to the host.

GO annotations

AspectTerm
Cellular Componentcell outer membrane
Cellular Componentcell surface

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Outer surface protein C

Gene names

    • Name
      ospC

Organism names

Accessions

  • Primary accession
    Q44977

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, lipidation, chain.

Type
IDPosition(s)Description
Signal1-18
Lipidation19N-palmitoyl cysteine
Lipidation19S-diacylglycerol cysteine
ChainPRO_500770282319-211Outer surface protein C

Keywords

Interaction

Subunit

Homodimer (Probable). Interacts with tick I.ricinus salivary protein Iric-1, Iric-2 and Iric-3 (PubMed:33401196).
Binds human (host) plasminogen (By similarity).

Family & Domains

Sequence similarities

Belongs to the OspC lipoprotein family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    211
  • Mass (Da)
    22,214
  • Last updated
    1996-11-01 v1
  • Checksum
    BFE8C7820CDE10D3
MKKNTLSAILMTLFLFISCNNSGKDGNTSANSADESVKGPNLTEISKKITDSNAVLLAVKEVEALLSSIDELAKAIGKKIKNDGSLGDEANHNESLLAGAYTISTLITQKLSKLNGSEGLKEKIAAAKKCSEEFSTKLKDNHAQLGIQGVTDENAKKAILKANAAGKDKGVEELEKLSGSLESLSKAAKEMLANSVKELTSPVVAESPKKP

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EF537412
EMBL· GenBank· DDBJ
ABQ42966.1
EMBL· GenBank· DDBJ
Genomic DNA
X81522
EMBL· GenBank· DDBJ
CAA57242.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ749599
EMBL· GenBank· DDBJ
CAG44434.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ749602
EMBL· GenBank· DDBJ
CAG44437.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ749605
EMBL· GenBank· DDBJ
CAG44440.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help