Q42438 · CDPK8_ARATH

Function

function

May play a role in signal transduction pathways that involve calcium as a second messenger.

Catalytic activity

Activity regulation

Activated by calcium. Autophosphorylation may play an important role in the regulation of the kinase activity (By similarity).

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site63-71ATP (UniProtKB | ChEBI)
Binding site86ATP (UniProtKB | ChEBI)
Active site181Proton acceptor
Binding site371Ca2+ 1 (UniProtKB | ChEBI)
Binding site375Ca2+ 1 (UniProtKB | ChEBI)
Binding site377Ca2+ 1 (UniProtKB | ChEBI)
Binding site382Ca2+ 1 (UniProtKB | ChEBI)
Binding site408Ca2+ 2 (UniProtKB | ChEBI)
Binding site410Ca2+ 2 (UniProtKB | ChEBI)
Binding site412Ca2+ 2 (UniProtKB | ChEBI)
Binding site414Ca2+ 2 (UniProtKB | ChEBI)
Binding site419Ca2+ 2 (UniProtKB | ChEBI)
Binding site444Ca2+ 3 (UniProtKB | ChEBI)
Binding site446Ca2+ 3 (UniProtKB | ChEBI)
Binding site448Ca2+ 3 (UniProtKB | ChEBI)
Binding site450Ca2+ 3 (UniProtKB | ChEBI)
Binding site455Ca2+ 3 (UniProtKB | ChEBI)
Binding site480Ca2+ 4 (UniProtKB | ChEBI)
Binding site482Ca2+ 4 (UniProtKB | ChEBI)
Binding site484Ca2+ 4 (UniProtKB | ChEBI)
Binding site486Ca2+ 4 (UniProtKB | ChEBI)
Binding site491Ca2+ 4 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functioncalcium ion binding
Molecular Functionprotein serine kinase activity
Molecular Functionprotein serine/threonine kinase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Calcium-dependent protein kinase 8
  • EC number
  • Alternative names
    • Calcium-dependent protein kinase isoform CDPK19 (AtCDPK19)

Gene names

    • Name
      CPK8
    • Synonyms
      CDPK19
    • ORF names
      F7K24.200
    • Ordered locus names
      At5g19450

Organism names

  • Taxonomic identifier
  • Strains
    • Columbia
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q42438
  • Secondary accessions
    • Q0WUS5

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Cell membrane
; Lipid-anchor

Keywords

PTM/Processing

Features

Showing features for initiator methionine, lipidation, chain, modified residue.

TypeIDPosition(s)Description
Initiator methionine1Removed
Lipidation2N-myristoyl glycine
ChainPRO_00003633332-533Calcium-dependent protein kinase 8
Modified residue221Phosphoserine
Modified residue488Phosphoserine
Modified residue526Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-21Disordered
Domain57-315Protein kinase
Region321-351Autoinhibitory domain
Domain358-394EF-hand 1
Domain395-430EF-hand 2
Domain431-466EF-hand 3
Domain467-502EF-hand 4

Domain

There are 3 contiguous domains conserved in the CDPK subfamily: a kinase domain, an autoinhibitory (junction) domain and a calmodulin-like domain. The autoinhibitory domain (321-351) inactivates kinase activity under calcium-free conditions (By similarity).

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q42438-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    533
  • Mass (Da)
    59,941
  • Last updated
    1996-11-01 v1
  • Checksum
    8E9D9DD090C9FD1A
MGNCCASPGSETGSKKGKPKIKSNPFYSEAYTTNGSGTGFKLSVLKDPTGHDISLMYDLGREVGRGEFGITYLCTDIKTGEKYACKSISKKKLRTAVDIEDVRREVEIMKHMPRHPNIVSLKDAFEDDDAVHIVMELCEGGELFDRIVARGHYTERAAAAVMKTILEVVQICHKHGVMHRDLKPENFLFANKKETSALKAIDFGLSVFFKPGEGFNEIVGSPYYMAPEVLRRNYGPEVDIWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSETAKDLVRKMLEPDPKKRLSAAQVLEHSWIQNAKKAPNVSLGETVKARLKQFSVMNKLKKRALRVIAEHLSVEEVAGIKEAFEMMDSKKTGKINLEELKFGLHKLGQQQIPDTDLQILMEAADVDGDGTLNYGEFVAVSVHLKKMANDEHLHKAFSFFDQNQSDYIEIEELREALNDEVDTNSEEVVAAIMQDVDTDKDGRISYEEFAAMMKAGTDWRKASRQYSRERFNSLSLKLMREGSLQLEGEN

Q42438-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_0362901-55in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U20624
EMBL· GenBank· DDBJ
AAA67655.1
EMBL· GenBank· DDBJ
mRNA
U20627
EMBL· GenBank· DDBJ
AAA67658.1
EMBL· GenBank· DDBJ
Genomic DNA
AF296837
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CP002688
EMBL· GenBank· DDBJ
AED92708.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002688
EMBL· GenBank· DDBJ
AED92709.1
EMBL· GenBank· DDBJ
Genomic DNA
AK227066
EMBL· GenBank· DDBJ
BAE99123.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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