Q42384 · PRL1_ARATH

Function

function

Pleiotropic regulator of glucose, stress and hormone responses. Also regulates cytochrome P450 CYP90A1/CPD. Coordinates the expression of hormone- and stress-related genes and genes related to cell wall modification and growth, leading to altered sugar-dependent growth and developmental responses. Component of the MAC complex that probably regulates defense responses through transcriptional control and thereby is essential for plant innate immunity. By suppressing the expression of several 1O2-responsive genes, PRL1 seems to play a major role in modulating responses of plants to environmental changes by interconnecting 1O2-mediated retrograde signaling with other signaling pathways. Acts as a negative regulator of SNF1-related protein kinases AKIN10 and AKIN11 via the inhibition of their interaction with SKP1/ASK1. Component of the CUL4-RBX1-DDB1-PRL1 E3 ubiquitin-protein ligase complex, PRL1 may function as the substrate recognition module within this complex, leading to the AKIN10 degradation.

Pathway

Protein modification; protein ubiquitination.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentCul4-RING E3 ubiquitin ligase complex
Cellular Componentcytosol
Cellular Componentnucleus
Biological Processcotyledon development
Biological Processdefense response to bacterium
Biological Processdefense response to fungus
Biological Processfruit development
Biological Processhormone-mediated signaling pathway
Biological Processinnate immune response
Biological Processleaf development
Biological ProcessmRNA splicing, via spliceosome
Biological Processnegative regulation of DNA-templated transcription
Biological Processprotein ubiquitination
Biological Processproteolysis
Biological Processresponse to glucose
Biological Processroot development
Biological Processsugar mediated signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein pleiotropic regulatory locus 1
  • Short names
    Protein PRL1
  • Alternative names
    • MOS4-associated complex protein 2 (MAC protein 2)

Gene names

    • Name
      PRL1
    • Synonyms
      MAC2
    • ORF names
      dl3990w, FCAALL.40
    • Ordered locus names
      At4g15900

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q42384

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Hypersensitivity to glucose and sucrose. Enhanced sensitivity of plants to stress and to growth hormones including cytokinin, ethylene, abscisic acid, and auxin. Accumulation of sugars and starch in leaves, and root elongation. Cell elongation defects. Enhanced susceptibility to virulent and avirulent pathogens.

Variants

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The viewer provides 31 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000511571-486Protein pleiotropic regulatory locus 1

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Component of the multiprotein assembly MOS4-associated complex (MAC) at least composed of MOS4, CDC5, PRL1 and PRP19 (PubMed:17575050, PubMed:19629177).
Interacts with CDC5 (PubMed:17575050).
Component of the CUL4-RBX1-DDB1-PRL1 E3 ubiquitin-protein ligase complex. Interacts with DDB1A through its DWD motif (PubMed:18223036).
Interacts with AKIN10, AKIN11 and PIPC (PubMed:10220464).
Interacts with KAP2 (PubMed:9765207).

Binary interactions

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, repeat, motif.

TypeIDPosition(s)Description
Region62-101Disordered
Compositional bias71-101Polar residues
Repeat174-204WD 1
Repeat216-246WD 2
Repeat258-288WD 3
Motif275-290DWD box 1
Repeat300-330WD 4
Motif317-332DWD box 2
Repeat342-371WD 5
Repeat384-413WD 6
Repeat433-463WD 7
Region465-486Disordered

Domain

The DWD box is required for interaction with DDB1A.

Sequence similarities

Belongs to the WD repeat PRL1/PRL2 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    486
  • Mass (Da)
    54,009
  • Last updated
    1996-11-01 v1
  • Checksum
    604D3E6FCDA8A998
MPAPTTEIEPIEAQSLKKLSLKSLKRSLELFSPVHGQFPPPDPEAKQIRLSHKMKVAFGGVEPVVSQPPRQPDRINEQPGPSNALSLAAPEGSKSTQKGATESAIVVGPTLLRPILPKGLNYTGSSGKSTTIIPANVSSYQRNLSTAALMERIPSRWPRPEWHAPWKNYRVIQGHLGWVRSVAFDPSNEWFCTGSADRTIKIWDVATGVLKLTLTGHIEQVRGLAVSNRHTYMFSAGDDKQVKCWDLEQNKVIRSYHGHLSGVYCLALHPTLDVLLTGGRDSVCRVWDIRTKMQIFALSGHDNTVCSVFTRPTDPQVVTGSHDTTIKFWDLRYGKTMSTLTHHKKSVRAMTLHPKENAFASASADNTKKFSLPKGEFCHNMLSQQKTIINAMAVNEDGVMVTGGDNGSIWFWDWKSGHSFQQSETIVQPGSLESEAGIYAACYDNTGSRLVTCEADKTIKMWKEDENATPETHPINFKPPKEIRRF

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias71-101Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X82824
EMBL· GenBank· DDBJ
CAA58031.1
EMBL· GenBank· DDBJ
Genomic DNA
X82825
EMBL· GenBank· DDBJ
CAA58032.1
EMBL· GenBank· DDBJ
mRNA
Z97339
EMBL· GenBank· DDBJ
CAB10369.1
EMBL· GenBank· DDBJ
Genomic DNA
AL161542
EMBL· GenBank· DDBJ
CAB78632.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002687
EMBL· GenBank· DDBJ
AEE83664.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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