Q3ZCQ6 · Q3ZCQ6_HUMAN
- ProteinSLC12A6 protein
- GeneSLC12A6
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids943 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
Catalytic activity
- chloride(in) + K+(in) = chloride(out) + K+(out)
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Cellular Component | synapse | |
Molecular Function | potassium:chloride symporter activity | |
Biological Process | cell volume homeostasis | |
Biological Process | chemical synaptic transmission | |
Biological Process | chloride ion homeostasis | |
Biological Process | potassium ion homeostasis | |
Biological Process | potassium ion import across plasma membrane |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ3ZCQ6
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 127-147 | Helical | ||||
Sequence: GTFMGVYLPCLQNIFGVILFL | ||||||
Transmembrane | 153-175 | Helical | ||||
Sequence: VGTAGVLQAFAIVLICCCCTMLT | ||||||
Transmembrane | 213-238 | Helical | ||||
Sequence: FYLGTTFAAAMYILGAIEIFLVYIVP | ||||||
Transmembrane | 259-278 | Helical | ||||
Sequence: MRVYGTAFLVLMVLVVFIGV | ||||||
Transmembrane | 284-303 | Helical | ||||
Sequence: FASLFLACVIVSILAIYAGA | ||||||
Transmembrane | 417-437 | Helical | ||||
Sequence: YVLVDITTSFTLLVGIFFPSV | ||||||
Transmembrane | 457-484 | Helical | ||||
Sequence: IPIGTILAILTTSFVLDLSNVVLFGACI | ||||||
Transmembrane | 563-581 | Helical | ||||
Sequence: WALLLTAAIAELGILIASL | ||||||
Transmembrane | 587-608 | Helical | ||||
Sequence: ILSMFFLMCYLFVNLACALQTL | ||||||
Transmembrane | 620-637 | Helical | ||||
Sequence: YYHWALSFMGMSICLALM |
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-17 | Polar residues | ||||
Sequence: MSEMSGATTSLATVALD | ||||||
Region | 1-26 | Disordered | ||||
Sequence: MSEMSGATTSLATVALDPPSDRTSHP | ||||||
Region | 101-122 | Disordered | ||||
Sequence: TQGAKEHEEAENITEGKKKPTK | ||||||
Compositional bias | 104-118 | Basic and acidic residues | ||||
Sequence: AKEHEEAENITEGKK | ||||||
Domain | 132-304 | Amino acid permease/ SLC12A | ||||
Sequence: VYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAI | ||||||
Domain | 423-702 | Amino acid permease/ SLC12A | ||||
Sequence: TTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVLDLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLL | ||||||
Domain | 716-834 | SLC12A transporter C-terminal | ||||
Sequence: PRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLV | ||||||
Domain | 848-922 | SLC12A transporter C-terminal | ||||
Sequence: FSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMVR |
Sequence similarities
Belongs to the SLC12A transporter family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length943
- Mass (Da)103,885
- Last updated2005-09-27 v1
- Checksum29A4BDD9696C0112
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-17 | Polar residues | ||||
Sequence: MSEMSGATTSLATVALD | ||||||
Compositional bias | 104-118 | Basic and acidic residues | ||||
Sequence: AKEHEEAENITEGKK |