Q3ZCJ6 · Q3ZCJ6_BOVIN
- ProteinEpoxide hydrolase
- GeneEPHX1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids451 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.
Catalytic activity
- 1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol
- 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = 11,12-dihydroxy-(5Z,8Z,14Z)-eicosatrienoateThis reaction proceeds in the forward direction.
- 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H+This reaction proceeds in the forward direction.
- 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = 8,9-dihydroxy-(5Z,11Z,14Z)-eicosatrienoateThis reaction proceeds in the forward direction.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 226 | Nucleophile | ||||
Sequence: D | ||||||
Active site | 373 | Proton donor | ||||
Sequence: Y | ||||||
Active site | 427 | Proton acceptor | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | cis-stilbene-oxide hydrolase activity | |
Molecular Function | epoxide hydrolase activity | |
Biological Process | arachidonic acid metabolic process | |
Biological Process | catabolic process | |
Biological Process | epoxide metabolic process | |
Biological Process | response to toxic substance |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameEpoxide hydrolase
- EC number
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionQ3ZCJ6
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Single-pass type III membrane protein
Membrane ; Single-pass type III membrane protein
Microsome membrane ; Single-pass type III membrane protein
Keywords
- Cellular component
PTM/Processing
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 48-157 | Epoxide hydrolase N-terminal | ||||
Sequence: IRPFKVETSDEEINDLHQRIDRVRLTPPLEDSRFHYGFNSNYLKKIISYWRNEFDWRKQVEILNKYPHFKTKIEGLDIHFIHVKPPNLPSGQTPKPLLMVHGWPGSFYEF |
Sequence similarities
Belongs to the peptidase S33 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length451
- Mass (Da)52,197
- Last updated2005-09-27 v1
- Checksum805FB6B956A4FAB6
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A3Q1M9R4 | A0A3Q1M9R4_BOVIN | EPHX1 | 510 | ||
F6RAL2 | F6RAL2_BOVIN | EPHX1 | 412 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC102117 EMBL· GenBank· DDBJ | AAI02118.1 EMBL· GenBank· DDBJ | mRNA |