Q3ZAS0 · SL9A2_MOUSE

  • Protein
    Sodium/hydrogen exchanger 2
  • Gene
    Slc9a2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Plasma membrane Na+/H+ antiporter (PubMed:14962844, PubMed:16690903).
Mediates the electroneutral exchange of intracellular H+ ions for extracellular Na+ (PubMed:14962844).
Major apical Na+/H+ exchanger in the base of the colonic crypt (PubMed:14962844, PubMed:16690903).
Controls in the colonic crypt intracellular pH (pHi) to direct colonic epithelial cell differentiation into the absorptive enterocyte lineage at the expense of the secretory lineage (PubMed:14962844, PubMed:34985202).

Catalytic activity

Activity regulation

In colonic crypts activated by low pHi, hyperosmolarity, and an increase in intracellular cAMP levels.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentbrush border
Cellular Componentplasma membrane
Molecular Functionpotassium:proton antiporter activity
Molecular Functionsodium:proton antiporter activity
Biological Processepithelial cell differentiation
Biological Processpotassium ion transmembrane transport
Biological Processprotein localization
Biological Processregulation of intracellular pH
Biological Processregulation of pH
Biological Processsodium ion import across plasma membrane
Biological Processsodium ion transmembrane transport
Biological Processsodium ion transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sodium/hydrogen exchanger 2
  • Alternative names
    • Na(+)/H(+) exchanger 2 (NHE-2)
    • Sodium/hydrogen exchanger
    • Solute carrier family 9 member 2

Gene names

    • Name
      Slc9a2
    • Synonyms
      Nhe2

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q3ZAS0

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane108-128Helical
Transmembrane139-159Helical
Transmembrane170-190Helical
Transmembrane210-230Helical
Transmembrane238-258Helical
Transmembrane279-299Helical
Transmembrane309-329Helical
Transmembrane362-382Helical
Transmembrane393-413Helical
Transmembrane431-451Helical
Transmembrane460-480Helical

Keywords

Phenotypes & Variants

Disruption phenotype

SLC9A2 null mice do not develop diarrhea, have no changes in quantitated intestinal Na+ absorption, however mice develop a sharp reduction in the number of gastric parietal and zymogenic cells associated with a loss of net acid secretion in adult but not in juvenile mice (PubMed:11099134, PubMed:9502765).
SLC9A2 null mice also exhibited reduced recovery from laser-induced ulceration of the stomach (PubMed:21900251).
Double-knockout of SLC9A2 and SLC9A3 are not significantly different than the SLC9A3-deficient alone in diarrhea, intestinal Na+ absorption, or reduced life expectancy (PubMed:11705743).
Steady-state pH intracellular is significantly altered along the colonic crypt axis in deficicent mice (PubMed:34985202).

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 20 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_50150975481-814Sodium/hydrogen exchanger 2

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the colonic epithelium predominantly in the cryptal region. Maximally expressed in the luminal membrane near the crypt base and in the middle of the crypt (at protein level) (PubMed:14962844).
Expressed in gastric epithelium (at protein level) (PubMed:21900251).

Gene expression databases

Interaction

Subunit

Interacts with CHP1 and CHP2.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region647-710Disordered
Compositional bias677-691Basic and acidic residues
Compositional bias692-710Polar residues
Region740-814Disordered
Compositional bias752-766Polar residues
Compositional bias772-787Basic and acidic residues
Compositional bias799-814Basic and acidic residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    814
  • Mass (Da)
    91,646
  • Last updated
    2005-09-27 v1
  • Checksum
    8543A204ED2528C2
MGPRGTAHSVRAPLSWLLLLLLSLQVAVPAGALAETLLDAPRARGASSNPPSPASVVAPGTTPFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLLLGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENFGTIFWYAVVGTLWNSIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQMKTIQTVDVFAGIANFFVVGIGGVLIGILLGFIAAFTTRFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLIWRALGVFVLTQVINWFRTIPLTFKDQFIIAYGGLRGAICFALVFLLPATVFPRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVKRSNKKQQAVSEEIHCRFFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRKLLIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPSFASLNDCREEKIRKLTPGEMDEIREILSRNLYQIRQRTLSYNRHNLTADTSERQAKEILIRRRHSLRESLRKDNSSNRERRASTSTSRYLSLPKNTKLPEKLQKKKKVSNADGNSSDSDPDVGTTVLNLQPRTRRFLPDQFSKKASQAYKMEWKNEVDVGSVRVPPSVSPAPRSKDGGTQTPGLLRQPLLSKDQRFGRGREDSLTEDVPPKPPPRLVRRASEPGNRKGRLGNEKP

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
Q3TM63Q3TM63_MOUSESlc9a2336

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias677-691Basic and acidic residues
Compositional bias692-710Polar residues
Compositional bias752-766Polar residues
Compositional bias772-787Basic and acidic residues
Compositional bias799-814Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC154392
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC103685
EMBL· GenBank· DDBJ
AAI03686.1
EMBL· GenBank· DDBJ
mRNA
BC104737
EMBL· GenBank· DDBJ
AAI04738.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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