Q3Z6R4 · LSPA_DEHM1

Function

function

This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

Catalytic activity

  • Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.
    EC:3.4.23.36 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; lipoprotein biosynthesis (signal peptide cleavage).

Features

Showing features for active site.

116020406080100120140160
TypeIDPosition(s)Description
Active site118
Active site132

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionaspartic-type endopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lipoprotein signal peptidase
  • EC number
  • Alternative names
    • Prolipoprotein signal peptidase
    • Signal peptidase II
      (SPase II
      )

Gene names

    • Name
      lspA
    • Ordered locus names
      DET1374

Organism names

Accessions

  • Primary accession
    Q3Z6R4

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane60-80Helical
Transmembrane84-104Helical
Transmembrane127-147Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000582321-160Lipoprotein signal peptidase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the peptidase A8 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    160
  • Mass (Da)
    17,032
  • Last updated
    2005-09-27 v1
  • Checksum
    5BEFFC9DBA18CA16
MTRGLVFFVSAACGVLADQLSKFIIAANLTPGTAIPESGFFQIVHVHNTGAAFSIFRGHTEWLIAASCLGVILALTAFFLRKKLPFLDTRPGVAALGIILAGTIGNLIDRVRLGYVTDFIQVGNFPTFNMADSCLTLGIIWLVLLYLTSSHSGGDASENA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000027
EMBL· GenBank· DDBJ
AAW39366.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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