Q3YAA1 · Q3YAA1_DANRE
- ProteinIntegrin beta
- Geneitgb1a
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids798 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell surface | |
Cellular Component | focal adhesion | |
Cellular Component | integrin complex | |
Cellular Component | lamellipodium | |
Cellular Component | melanosome | |
Cellular Component | ruffle membrane | |
Cellular Component | synapse | |
Molecular Function | collagen binding involved in cell-matrix adhesion | |
Molecular Function | fibronectin binding | |
Molecular Function | integrin binding | |
Molecular Function | protein kinase binding | |
Molecular Function | signaling receptor activity | |
Biological Process | atrioventricular valve morphogenesis | |
Biological Process | cell-cell adhesion | |
Biological Process | ERK1 and ERK2 cascade | |
Biological Process | integrin-mediated signaling pathway | |
Biological Process | muscle organ development | |
Biological Process | phosphatidylinositol 3-kinase/protein kinase B signal transduction | |
Biological Process | positive regulation of sprouting angiogenesis |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameIntegrin beta
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ3YAA1
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Cell projection, invadopodium membrane ; Single-pass type I membrane protein
Cell projection, ruffle membrane ; Single-pass type I membrane protein
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 729-751 | Helical | ||||
Sequence: IIPIVAGVVAGIVLIGLALLLIW |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-20 | |||||
Sequence: MDLKLLFISALLGIISCSRA | ||||||
Chain | PRO_5035034372 | 21-798 | Integrin beta | |||
Sequence: QQEGNECIKANALSCGECIQVGDKCGWCTDAEFLKQGEPTSARCDELESLKKRGCAEAKIENPHGSQRILKNTPVTNRKKGAEKLRPEDITQIQPQKLSLQLRSGEPQNIKLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKNLGTSLMKEMSKITSDFRIGFGSFVEKTVMPYISTTPAKLLNPCTGDQNCTSPFSYKNVLKLTSNGQRFNSLVGQQQISGNLDSPEGGFDAIMQVAVCGEHIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGRCHLENDMYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVINLIVDAYNSLSSEVILENSKLPEGVTITYQSRCKNGVVNEGESGRKCSNISIGDEVSFNINITAQGCPKQGKTETIKIKPLGFTEEVEITLSFICECECHKHAMKNSPLCHNGNGSFECGACRCNKGRVGRQCECRKDEVSTEDLDKNCRKDNGTDICSNNGECVCGTCECKKRENPEERYSGKYCECDNFNCDRSNNKLCGGHGRCECRVCVCDANYTGSACDCSLDTSTCLASNKQICNGRGICECGTCRCTDPKFQGPTCEICPTCPGVCTEHKECVQCRAFGTGEKKDTCKRDCSYFNLIEVEDRDKLPQPVQAFPLMHCKERDARDCWFYYTYAVNNNTEKEVHVVKTMECPPGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVINPKYEGK | ||||||
Disulfide bond | 27↔464 | |||||
Sequence: CIKANALSCGECIQVGDKCGWCTDAEFLKQGEPTSARCDELESLKKRGCAEAKIENPHGSQRILKNTPVTNRKKGAEKLRPEDITQIQPQKLSLQLRSGEPQNIKLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKNLGTSLMKEMSKITSDFRIGFGSFVEKTVMPYISTTPAKLLNPCTGDQNCTSPFSYKNVLKLTSNGQRFNSLVGQQQISGNLDSPEGGFDAIMQVAVCGEHIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGRCHLENDMYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVINLIVDAYNSLSSEVILENSKLPEGVTITYQSRCKNGVVNEGESGRKCSNISIGDEVSFNINITAQGCPKQGKTETIKIKPLGFTEEVEITLSFICEC | ||||||
Disulfide bond | 35↔45 | |||||
Sequence: CGECIQVGDKC | ||||||
Disulfide bond | 38↔75 | |||||
Sequence: CIQVGDKCGWCTDAEFLKQGEPTSARCDELESLKKRGC | ||||||
Disulfide bond | 48↔64 | |||||
Sequence: CTDAEFLKQGEPTSARC | ||||||
Disulfide bond | 206↔212 | |||||
Sequence: CTGDQNC | ||||||
Disulfide bond | 260↔300 | |||||
Sequence: CGEHIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGRC | ||||||
Disulfide bond | 400↔414 | |||||
Sequence: CKNGVVNEGESGRKC | ||||||
Disulfide bond | 434↔691 | |||||
Sequence: CPKQGKTETIKIKPLGFTEEVEITLSFICECECHKHAMKNSPLCHNGNGSFECGACRCNKGRVGRQCECRKDEVSTEDLDKNCRKDNGTDICSNNGECVCGTCECKKRENPEERYSGKYCECDNFNCDRSNNKLCGGHGRCECRVCVCDANYTGSACDCSLDTSTCLASNKQICNGRGICECGTCRCTDPKFQGPTCEICPTCPGVCTEHKECVQCRAFGTGEKKDTCKRDCSYFNLIEVEDRDKLPQPVQAFPLMHC | ||||||
Disulfide bond | 462↔466 | |||||
Sequence: CECEC | ||||||
Disulfide bond | 477↔489 | |||||
Sequence: CHNGNGSFECGAC | ||||||
Disulfide bond | 486↔525 | |||||
Sequence: CGACRCNKGRVGRQCECRKDEVSTEDLDKNCRKDNGTDIC | ||||||
Disulfide bond | 491↔500 | |||||
Sequence: CNKGRVGRQC | ||||||
Disulfide bond | 502↔516 | |||||
Sequence: CRKDEVSTEDLDKNC | ||||||
Disulfide bond | 531↔536 | |||||
Sequence: CVCGTC | ||||||
Disulfide bond | 533↔568 | |||||
Sequence: CGTCECKKRENPEERYSGKYCECDNFNCDRSNNKLC | ||||||
Disulfide bond | 538↔553 | |||||
Sequence: CKKRENPEERYSGKYC | ||||||
Disulfide bond | 555↔560 | |||||
Sequence: CDNFNC | ||||||
Disulfide bond | 574↔579 | |||||
Sequence: CECRVC | ||||||
Disulfide bond | 576↔607 | |||||
Sequence: CRVCVCDANYTGSACDCSLDTSTCLASNKQIC | ||||||
Disulfide bond | 581↔590 | |||||
Sequence: CDANYTGSAC | ||||||
Disulfide bond | 592↔599 | |||||
Sequence: CSLDTSTC | ||||||
Disulfide bond | 613↔618 | |||||
Sequence: CECGTC | ||||||
Disulfide bond | 615↔661 | |||||
Sequence: CGTCRCTDPKFQGPTCEICPTCPGVCTEHKECVQCRAFGTGEKKDTC | ||||||
Disulfide bond | 620↔630 | |||||
Sequence: CTDPKFQGPTC | ||||||
Disulfide bond | 633↔636 | |||||
Sequence: CPTC | ||||||
Disulfide bond | 640↔649 | |||||
Sequence: CTEHKECVQC | ||||||
Disulfide bond | 646↔723 | |||||
Sequence: CVQCRAFGTGEKKDTCKRDCSYFNLIEVEDRDKLPQPVQAFPLMHCKERDARDCWFYYTYAVNNNTEKEVHVVKTMEC | ||||||
Disulfide bond | 665↔699 | |||||
Sequence: CSYFNLIEVEDRDKLPQPVQAFPLMHCKERDARDC |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 26-76 | PSI | ||||
Sequence: ECIKANALSCGECIQVGDKCGWCTDAEFLKQGEPTSARCDELESLKKRGCA | ||||||
Domain | 34-464 | Integrin beta subunit VWA | ||||
Sequence: SCGECIQVGDKCGWCTDAEFLKQGEPTSARCDELESLKKRGCAEAKIENPHGSQRILKNTPVTNRKKGAEKLRPEDITQIQPQKLSLQLRSGEPQNIKLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKNLGTSLMKEMSKITSDFRIGFGSFVEKTVMPYISTTPAKLLNPCTGDQNCTSPFSYKNVLKLTSNGQRFNSLVGQQQISGNLDSPEGGFDAIMQVAVCGEHIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGRCHLENDMYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVINLIVDAYNSLSSEVILENSKLPEGVTITYQSRCKNGVVNEGESGRKCSNISIGDEVSFNINITAQGCPKQGKTETIKIKPLGFTEEVEITLSFICEC | ||||||
Domain | 640-728 | Integrin beta subunit tail | ||||
Sequence: CTEHKECVQCRAFGTGEKKDTCKRDCSYFNLIEVEDRDKLPQPVQAFPLMHCKERDARDCWFYYTYAVNNNTEKEVHVVKTMECPPGPD | ||||||
Domain | 752-798 | Integrin beta subunit cytoplasmic | ||||
Sequence: KLLMIIHDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVINPKYEGK |
Sequence similarities
Belongs to the integrin beta chain family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length798
- Mass (Da)88,592
- Last updated2005-09-27 v1
- Checksum3A6514ADB6A2C46E
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M6YW86 | A0A8M6YW86_DANRE | itgb1a | 802 | ||
F1QG85 | F1QG85_DANRE | itgb1a | 798 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DQ149101 EMBL· GenBank· DDBJ | AAZ78240.1 EMBL· GenBank· DDBJ | mRNA |