Q3V3Q2 · Q3V3Q2_MOUSE
- ProteinSH2 domain-containing protein
- GeneSyk
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids280 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Publications for Q3V3Q2
A unique insert in the linker domain of Syk is necessary for its function in immunoreceptor signalling.
- CategoriesFunction
- SourceMGI: 99515
Restoration of thymocyte development and function in zap-70-/- mice by the Syk protein tyrosine kinase.
- CategoriesFunction
- SourceMGI: 99515
The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen.
- CategoriesPTM / Processing
- SourceMGI: 99515
The product of the proto-oncogene c-cbl: a negative regulator of the Syk tyrosine kinase.
- CategoriesFunction
- SourceMGI: 99515
Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130.
- CategoriesPTM / Processing
- SourceMGI: 99515
Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells.
- CategoriesFunction
- SourceMGI: 99515
- PubMed
- Europe PMC
- Oncogene 13:2595-2605 ()
Mapped toDifferential intrinsic enzymatic activity of Syk and Zap-70 protein- tyrosine kinases.
- CategoriesPTM / Processing
- SourceMGI: 99515
Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinase.
- CategoriesFunction, Sequences
- SourceMGI: 99515
Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase.
- CategoriesFunction, PTM / Processing, Interaction
- SourceMGI: 99515
Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling.
- CategoriesSequences
- SourceMGI: 99515
- PubMed
- Europe PMC
- J Immunol 152:4758-4766 ()
Mapped toChromosomal location of the Syk and ZAP-70 tyrosine kinase genes in mice and humans.
- CategoriesFunction, Sequences
- SourceMGI: 99515
Association of p72syk with the src homology-2 (SH2) domains of PLC gamma 1 in B lymphocytes.
- CategoriesInteraction
- SourceMGI: 99515
Molecular characterization of the murine syk protein tyrosine kinase cDNA, transcripts and protein.
- CategoriesSequences
- SourceMGI: 99515
Essential role for ZAP-70 in both positive and negative selection of thymocytes.
- CategoriesFunction
- SourceMGI: 99515
Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells.
- CategoriesFunction
- SourceMGI: 99515
Syk tyrosine kinase required for mouse viability and B-cell development.
- CategoriesFunction
- SourceMGI: 99515
Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 99515
Phosphorylation of (Ser 291) in the linker insert of Syk negatively regulates ITAM signaling in platelets.
- AnnotationPhosphorylation of (Ser 291) in the linker insert of Syk negatively regulates ITAM signaling in platelets.
- SourceGeneRif: 20963
Dectin1 contributes to hypertensive vascular injury by promoting macrophage infiltration through activating the Syk/NF-kappaB pathway.
- AnnotationDectin1 contributes to hypertensive vascular injury by promoting macrophage infiltration through activating the Syk/NF-kappaB pathway.
- SourceGeneRif: 20963
Biochemical characterization of spleen tyrosine kinase (SYK) isoforms in platelets.
- AnnotationBiochemical characterization of spleen tyrosine kinase (SYK) isoforms in platelets.
- SourceGeneRif: 20963