Cops2 but not the whole COP9 signalosome is essential for pluripotency maintenance in mouse embryonic stem cells. Down-regulation of Cops2 reduces expression of pluripotency genes slows proliferation rate arrests G2/M cell cycle and compromises ESC embryoid differentiation. Cops2 binds to Nanog protein and prevents degradation. Cops2 functions as transcriptional corepressor to facilitate pluripotency maintenance.
these data indicate that Alien/ESET complex is involved in TRbeta1-mediated transcription repression of E2F1 and provide a molecular basis of thyroid hormone-induced repression of proliferation.
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