Q3V100 · Q3V100_MOUSE

  • Protein
    Mannose-6-phosphate isomerase
  • Gene
    Mpi
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Isomerase that catalyzes the interconversion of fructose-6-P and mannose-6-P and has a critical role in the supply of D-mannose derivatives required for many eukaryotic glycosylation reactions.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site110Zn2+ (UniProtKB | ChEBI)
Binding site112Zn2+ (UniProtKB | ChEBI)
Binding site137Zn2+ (UniProtKB | ChEBI)
Binding site276Zn2+ (UniProtKB | ChEBI)
Active site295

GO annotations

AspectTerm
Molecular Functionmannose-6-phosphate isomerase activity
Molecular Functionzinc ion binding
Biological ProcessGDP-mannose biosynthetic process
Biological Processmannose to fructose-6-phosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Mannose-6-phosphate isomerase
  • EC number

Gene names

    • Name
      Mpi
    • Synonyms
      Mpi1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q3V100

Organism-specific databases

PTM/Processing

Proteomic databases

PTM databases

Expression

Gene expression databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-154Phosphomannose isomerase type I catalytic
Domain170-257Phosphomannose isomerase type I helical insertion
Domain337-380Phosphomannose isomerase type I C-terminal

Sequence similarities

Belongs to the mannose-6-phosphate isomerase type 1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    423
  • Mass (Da)
    46,575
  • Last updated
    2005-10-11 v1
  • Checksum
    3A49506D1249B670
MASPRVFPLSCVVQQYAWGKVGSKSEVACLLASSDPLAQISEDKPYAELWMGTHPRGDAKILDNRISQKTLGQWIAENPDCLGSKVKNTFNGKLPFLFKVLSVDTALSIQAHPNKELAEKLHLQAPEHYPDANHKPEMAIALTSFQGLCGFRPVEEIVTFMKKVPEFQLLIGDDATAQLKESVGGDTEAMASALRNCFSHLMKSEKKVVVEQLNLLVKRISQQVFDGNNMEDIYGKLLLQLHQQHPGDIGCFAIYFLNLLTLKPGEAMFLDANVPHAYLKGDCVECMACSDNTVRAGLTPKFIDVPTLCEMLNYTPSPSNNRLFAPAQSQDDPYLSIYDPPVPDFTVMKMEVPSSVTEYKVSTLDSASILLMVQGTVTAIIPSAHAEIPLYRGGVLFIAANESVLLKITVPKDLLIFRACCLL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK132777
EMBL· GenBank· DDBJ
BAE21353.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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