Q3V100 · Q3V100_MOUSE
- ProteinMannose-6-phosphate isomerase
- GeneMpi
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids423 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Isomerase that catalyzes the interconversion of fructose-6-P and mannose-6-P and has a critical role in the supply of D-mannose derivatives required for many eukaryotic glycosylation reactions.
Catalytic activity
- D-mannose 6-phosphate = D-fructose 6-phosphate
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | mannose-6-phosphate isomerase activity | |
Molecular Function | zinc ion binding | |
Biological Process | GDP-mannose biosynthetic process | |
Biological Process | mannose to fructose-6-phosphate catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMannose-6-phosphate isomerase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ3V100
Organism-specific databases
PTM/Processing
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 6-154 | Phosphomannose isomerase type I catalytic | ||||
Sequence: VFPLSCVVQQYAWGKVGSKSEVACLLASSDPLAQISEDKPYAELWMGTHPRGDAKILDNRISQKTLGQWIAENPDCLGSKVKNTFNGKLPFLFKVLSVDTALSIQAHPNKELAEKLHLQAPEHYPDANHKPEMAIALTSFQGLCGFRPV | ||||||
Domain | 170-257 | Phosphomannose isomerase type I helical insertion | ||||
Sequence: LIGDDATAQLKESVGGDTEAMASALRNCFSHLMKSEKKVVVEQLNLLVKRISQQVFDGNNMEDIYGKLLLQLHQQHPGDIGCFAIYFL | ||||||
Domain | 337-380 | Phosphomannose isomerase type I C-terminal | ||||
Sequence: IYDPPVPDFTVMKMEVPSSVTEYKVSTLDSASILLMVQGTVTAI |
Sequence similarities
Belongs to the mannose-6-phosphate isomerase type 1 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length423
- Mass (Da)46,575
- Last updated2005-10-11 v1
- Checksum3A49506D1249B670
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK132777 EMBL· GenBank· DDBJ | BAE21353.1 EMBL· GenBank· DDBJ | mRNA |