Q3V050 · S47A2_MOUSE
- ProteinMultidrug and toxin extrusion protein 2
- GeneSlc47a2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids573 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Multidrug efflux pump that functions as a H+/organic cation antiporter (PubMed:17715386).
May mediate testosterone efflux from the Leydig cells in the testes (PubMed:17715386).
May mediate testosterone efflux from the Leydig cells in the testes (PubMed:17715386).
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
0.71 mM | TEA |
Vmax | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|
0.004 nmol/min/mg | toward TEA |
pH Dependence
Optimum pH is 8.5. Active from pH 6 to 8.5.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | plasma membrane | |
Molecular Function | organic cation transmembrane transporter activity | |
Molecular Function | polyspecific organic cation:proton antiporter activity | |
Molecular Function | transmembrane transporter activity | |
Molecular Function | xenobiotic transmembrane transporter activity | |
Biological Process | organic cation transport | |
Biological Process | xenobiotic detoxification by transmembrane export across the plasma membrane |
Keywords
- Biological process
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameMultidrug and toxin extrusion protein 2
- Short namesMATE-2; mMATE-2
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ3V050
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-46 | Cytoplasmic | ||||
Sequence: MEPAEDSLGATIQPPELVRVPRGRSLRILLGLRGALSPDVRREAAA | ||||||
Transmembrane | 47-67 | Helical | ||||
Sequence: LVALAGPVFLAQLMIFLISIV | ||||||
Topological domain | 68-81 | Extracellular | ||||
Sequence: SSIFCGHLGKVELD | ||||||
Transmembrane | 82-102 | Helical | ||||
Sequence: AVTLAVSVVNVTGISVGTGLA | ||||||
Topological domain | 103-122 | Cytoplasmic | ||||
Sequence: SACDTLMSQSFGGKNLKRVG | ||||||
Transmembrane | 123-143 | Helical | ||||
Sequence: VILQRGILILLLCCFPCWAIF | ||||||
Topological domain | 144-161 | Extracellular | ||||
Sequence: LNTERLLLLLRQDPDVAR | ||||||
Transmembrane | 162-182 | Helical | ||||
Sequence: LAQVYVMICIPALPAAFLFQL | ||||||
Topological domain | 183-196 | Cytoplasmic | ||||
Sequence: QTRYLQSQGIIMPQ | ||||||
Transmembrane | 197-217 | Helical | ||||
Sequence: VIVGIAANVVNVGMNAFLLYA | ||||||
Topological domain | 218-225 | Extracellular | ||||
Sequence: LDLGVVGS | ||||||
Transmembrane | 226-246 | Helical | ||||
Sequence: AWANTTSQFFLSALLFLYVWW | ||||||
Topological domain | 247-266 | Cytoplasmic | ||||
Sequence: KRIHIHTWGGWTRECFQEWS | ||||||
Transmembrane | 267-286 | Helical | ||||
Sequence: SYTRLAIPSMFMVCIEWWTF | ||||||
Topological domain | 287-304 | Extracellular | ||||
Sequence: EIGTFLAGLVNVTELGAQ | ||||||
Transmembrane | 305-325 | Helical | ||||
Sequence: AVIYELASVAYMVPFGFGVAA | ||||||
Topological domain | 326-345 | Cytoplasmic | ||||
Sequence: SVRVGNALGAGNADQARCSC | ||||||
Transmembrane | 346-366 | Helical | ||||
Sequence: TTVLLCAGVCALLVGILLAAL | ||||||
Topological domain | 367-379 | Extracellular | ||||
Sequence: KDVVAYIFTNDKD | ||||||
Transmembrane | 380-400 | Helical | ||||
Sequence: IISLVSQVMPIFAPFHLFDAL | ||||||
Topological domain | 401-415 | Cytoplasmic | ||||
Sequence: AGTCGGVLRGTGKQK | ||||||
Transmembrane | 416-436 | Helical | ||||
Sequence: IGAVLNTIGYYGFGFPIGVSL | ||||||
Topological domain | 437-443 | Extracellular | ||||
Sequence: MFAAKLG | ||||||
Transmembrane | 444-464 | Helical | ||||
Sequence: IIGLWAGLIVCVSFQAFSYLI | ||||||
Topological domain | 465-545 | Cytoplasmic | ||||
Sequence: YILRTNWSRVAEQAQVRAGLKSTKELIPTPADLPILEREVMDGVILPDIIRPESQTGQLVVEENSQCAVPTVGEVLTGRQL | ||||||
Transmembrane | 546-566 | Helical | ||||
Sequence: VFYRGMALTVSVAVLIAGIVV | ||||||
Topological domain | 567-573 | Extracellular | ||||
Sequence: RVFNDRG |
Keywords
- Cellular component
Phenotypes & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 25 variants from UniProt as well as other sources including ClinVar and dbSNP.
Chemistry
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000312852 | 1-573 | Multidrug and toxin extrusion protein 2 | |||
Sequence: MEPAEDSLGATIQPPELVRVPRGRSLRILLGLRGALSPDVRREAAALVALAGPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTGISVGTGLASACDTLMSQSFGGKNLKRVGVILQRGILILLLCCFPCWAIFLNTERLLLLLRQDPDVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMNAFLLYALDLGVVGSAWANTTSQFFLSALLFLYVWWKRIHIHTWGGWTRECFQEWSSYTRLAIPSMFMVCIEWWTFEIGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCAGVCALLVGILLAALKDVVAYIFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNTIGYYGFGFPIGVSLMFAAKLGIIGLWAGLIVCVSFQAFSYLIYILRTNWSRVAEQAQVRAGLKSTKELIPTPADLPILEREVMDGVILPDIIRPESQTGQLVVEENSQCAVPTVGEVLTGRQLVFYRGMALTVSVAVLIAGIVVRVFNDRG |
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in testis; especially in testicular Leydig cells.
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length573
- Mass (Da)61,789
- Last updated2005-10-11 v1
- ChecksumB18968B12E84F805
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Z4YMV2 | Z4YMV2_MOUSE | Slc47a2 | 477 |
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK133432 EMBL· GenBank· DDBJ | BAE21655.1 EMBL· GenBank· DDBJ | mRNA | ||
AL669884 EMBL· GenBank· DDBJ | CAI25733.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
BC147619 EMBL· GenBank· DDBJ | AAI47620.1 EMBL· GenBank· DDBJ | mRNA | ||
BC157913 EMBL· GenBank· DDBJ | AAI57914.1 EMBL· GenBank· DDBJ | mRNA |