Q3V050 · S47A2_MOUSE

  • Protein
    Multidrug and toxin extrusion protein 2
  • Gene
    Slc47a2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Multidrug efflux pump that functions as a H+/organic cation antiporter (PubMed:17715386).
May mediate testosterone efflux from the Leydig cells in the testes (PubMed:17715386).

Caution

Human SLC47A2/MATE2 and rodent SLC47A2/MATE2 exhibit only low mutual sequence identity (38.1%) and different expression patterns. In fact, the counterparts of human SLC47A2/MATE2 have not been identified in rats and mice, and the counterpart of rodent SLC47A2/MATE2 has not been found in humans. The phylogenetic tree of mammalian MATE-type transporters clearly suggested that rodent SLC47A2/MATE2 would be classified into an new subgroup:SLC47A3/MATE3 family but not SLC47A2/MATE2 family. As the nomenclature and classification are confusing, PubMed:17715386 suggested to rename mouse and rat SLC47A2/MATE2 to SLC47A3/MATE3.

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
0.71 mMTEA
Vmax pH TEMPERATURE[C] NOTES EVIDENCE
0.004 nmol/min/mgtoward TEA

pH Dependence

Optimum pH is 8.5. Active from pH 6 to 8.5.

GO annotations

AspectTerm
Cellular Componentmembrane
Cellular Componentplasma membrane
Molecular Functionorganic cation transmembrane transporter activity
Molecular Functionpolyspecific organic cation:proton antiporter activity
Molecular Functiontransmembrane transporter activity
Molecular Functionxenobiotic transmembrane transporter activity
Biological Processorganic cation transport
Biological Processxenobiotic detoxification by transmembrane export across the plasma membrane

Keywords

Protein family/group databases

    • 2.A.66.1.16the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily

Names & Taxonomy

Protein names

  • Recommended name
    Multidrug and toxin extrusion protein 2
  • Short names
    MATE-2; mMATE-2
  • Alternative names
    • H(+)/organic cation antiporter kidney-specific
    • Solute carrier family 47 member 2

Gene names

    • Name
      Slc47a2
    • Synonyms
      Mate2

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q3V050
  • Secondary accessions
    • B2RXN1
    • Q5SS46

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-46Cytoplasmic
Transmembrane47-67Helical
Topological domain68-81Extracellular
Transmembrane82-102Helical
Topological domain103-122Cytoplasmic
Transmembrane123-143Helical
Topological domain144-161Extracellular
Transmembrane162-182Helical
Topological domain183-196Cytoplasmic
Transmembrane197-217Helical
Topological domain218-225Extracellular
Transmembrane226-246Helical
Topological domain247-266Cytoplasmic
Transmembrane267-286Helical
Topological domain287-304Extracellular
Transmembrane305-325Helical
Topological domain326-345Cytoplasmic
Transmembrane346-366Helical
Topological domain367-379Extracellular
Transmembrane380-400Helical
Topological domain401-415Cytoplasmic
Transmembrane416-436Helical
Topological domain437-443Extracellular
Transmembrane444-464Helical
Topological domain465-545Cytoplasmic
Transmembrane546-566Helical
Topological domain567-573Extracellular

Keywords

Phenotypes & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 25 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Chemistry

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003128521-573Multidrug and toxin extrusion protein 2

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in testis; especially in testicular Leydig cells.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    573
  • Mass (Da)
    61,789
  • Last updated
    2005-10-11 v1
  • Checksum
    B18968B12E84F805
MEPAEDSLGATIQPPELVRVPRGRSLRILLGLRGALSPDVRREAAALVALAGPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTGISVGTGLASACDTLMSQSFGGKNLKRVGVILQRGILILLLCCFPCWAIFLNTERLLLLLRQDPDVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMNAFLLYALDLGVVGSAWANTTSQFFLSALLFLYVWWKRIHIHTWGGWTRECFQEWSSYTRLAIPSMFMVCIEWWTFEIGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCAGVCALLVGILLAALKDVVAYIFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNTIGYYGFGFPIGVSLMFAAKLGIIGLWAGLIVCVSFQAFSYLIYILRTNWSRVAEQAQVRAGLKSTKELIPTPADLPILEREVMDGVILPDIIRPESQTGQLVVEENSQCAVPTVGEVLTGRQLVFYRGMALTVSVAVLIAGIVVRVFNDRG

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
Z4YMV2Z4YMV2_MOUSESlc47a2477

Sequence caution

The sequence CAI25733.1 differs from that shown. Reason: Erroneous gene model prediction

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK133432
EMBL· GenBank· DDBJ
BAE21655.1
EMBL· GenBank· DDBJ
mRNA
AL669884
EMBL· GenBank· DDBJ
CAI25733.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
BC147619
EMBL· GenBank· DDBJ
AAI47620.1
EMBL· GenBank· DDBJ
mRNA
BC157913
EMBL· GenBank· DDBJ
AAI57914.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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