Q3UTC9 · Q3UTC9_MOUSE
- ProteinProtein Mdm4
- GeneMdm4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids490 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleoplasm | |
Cellular Component | transcription repressor complex | |
Molecular Function | enzyme binding | |
Molecular Function | metal ion binding | |
Biological Process | cellular response to hypoxia | |
Biological Process | DNA damage response, signal transduction by p53 class mediator | |
Biological Process | negative regulation of apoptotic process | |
Biological Process | negative regulation of protein catabolic process | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | protein stabilization | |
Biological Process | protein-containing complex assembly | |
Biological Process | regulation of cell cycle |
Keywords
- Ligand
Names & Taxonomy
Protein names
- Recommended nameProtein Mdm4
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ3UTC9
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 23-109 | DM2 | ||||
Sequence: QISQQVRPKLQLLKILHAAGAQGEVFTMKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGDLLGCQSFSVKDPSPLYDMLRKNLVT | ||||||
Region | 132-167 | Disordered | ||||
Sequence: PSQDRLKHGATEYSNPRKRTEEEDTHTLPTSRHKCR | ||||||
Domain | 300-329 | RanBP2-type | ||||
Sequence: SEDEWQCTECKKFNSPSKRYCFRCWALRKD | ||||||
Domain | 437-478 | RING-type | ||||
Sequence: CSLCEKRPRDGNIIHGKTSHLTTCFHCARRLKKSGASCPACK |
Sequence similarities
Belongs to the MDM2/MDM4 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length490
- Mass (Da)55,091
- Last updated2005-10-11 v1
- ChecksumE3E1BA96A8C2BCFE
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
O35618 | MDM4_MOUSE | Mdm4 | 489 | ||
A0A087WQ20 | A0A087WQ20_MOUSE | Mdm4 | 128 | ||
A0A087WQ90 | A0A087WQ90_MOUSE | Mdm4 | 141 | ||
A0A087WQP2 | A0A087WQP2_MOUSE | Mdm4 | 110 | ||
A0A087WRX7 | A0A087WRX7_MOUSE | Mdm4 | 318 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK139529 EMBL· GenBank· DDBJ | BAE24051.1 EMBL· GenBank· DDBJ | mRNA |