Q3USZ8 · DIK2A_MOUSE
- ProteinDivergent protein kinase domain 2A
- GeneDipk2a
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids430 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
May play a role in cardiomyocyte proliferation through paracrine signaling and activation of the PI3-kinase signaling cascade.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | COPI vesicle coat | |
Cellular Component | COPI-coated vesicle | |
Cellular Component | extracellular region | |
Cellular Component | extracellular space | |
Cellular Component | Golgi membrane | |
Biological Process | cardiac muscle cell proliferation | |
Biological Process | negative regulation of smooth muscle cell apoptotic process | |
Biological Process | regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | |
Biological Process | vesicle targeting, to, from or within Golgi |
Names & Taxonomy
Protein names
- Recommended nameDivergent protein kinase domain 2A
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ3USZ8
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-35 | |||||
Sequence: MWRLVPLKLGRLSRALKLAALGSLLVLMLLHSPSL | ||||||
Chain | PRO_0000226038 | 36-430 | Divergent protein kinase domain 2A | |||
Sequence: LASWQRNELADRRFLQLNKCPACFGTSWCRRFLNGQVGFETWGRLRLLDFLNVKNVYFAQYGEPREGGRRRVVLKRLGSQRELAQLDQSICKRATGRPRCDLLQAMPRTEFARLNGDVRLLTPEAVEGWSDLVHCPSQRLLDRLVRRYAETKDSGSFLLRNLKDSERMQLLLTLAFNPEPLVLQSFPSDEGWPFAKYLGACGRMVAVNYVGEELWSYFNAPWEKRVDLAWQLMEIAEQLTNNDFEFALYLLDVSFDNFAVGPRDGKVIIVDAENVLVADKRLIRQNKPENWDVWYESKFDDCDKEACLSFSKEILCARVTVDHNYYAVCQNLLSRHATWRGTSGGLLHDPPSEIAKDGRLEALLDECTNPKKRYGRFQAAKELRGYLAQLSHNVR |
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in heart, brain, liver, spleen, kidney, lung, thymus, testis, ovary and muscle.
Developmental stage
As early as 12.5 dpc to 16.5 dpc, intense expression is restricted to mesenchymal condensations, which form the different cartilage elements of the developing skeleton. At 12.5 dpc, strongly expressed in all vertebrae, heart ventricle, dental follicle, interdigital tissue, tongue and cartilages of the basioccipital bone, maxilla, mandible and the region of the future nasal septum. At 14.5 and 16.5 dpc, expressed in ribs, long bones, interdigital tissue, metatarsals, dental follicle, cartilages of the mandible and nasal septum as well as vertebrae with stronger expression in posterior vertebrae. At 16.5 dpc, also expressed in paw bones and, in vertebrae, the expression is limited to mainly columnar, proliferating chondrocytes. At 4 days postnatal, intense expression in nasal cartilages, hair, dental and vibrissa follicles.
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length430
- Mass (Da)49,463
- Last updated2013-09-18 v2
- Checksum4A63FFC4E13379D0
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 3-22 | in Ref. 1; BAE24182 | ||||
Sequence: RLVPLKLGRLSRALKLAALG → MAVVLRMSNI | ||||||
Sequence conflict | 426-430 | in Ref. 1; BAE24182 | ||||
Sequence: SHNVR → KSQCEVVSSDLYIFFAEKALTKLNHQKNCLE |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK139920 EMBL· GenBank· DDBJ | BAE24182.1 EMBL· GenBank· DDBJ | mRNA | ||
AC160129 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |