Q3URC9 · Q3URC9_MOUSE

  • Protein
    Angiotensin-converting enzyme
  • Gene
    Ace2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.
chloride (UniProtKB | Rhea| CHEBI:17996 )

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site375Proton acceptor 1
Active site505Proton donor 1

GO annotations

AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentbrush border membrane
Cellular Componentcell surface
Cellular Componentcilium
Cellular Componentcytoplasm
Cellular Componentextracellular space
Molecular Functioncarboxypeptidase activity
Molecular Functionendopeptidase activity
Molecular Functionidentical protein binding
Molecular Functionmetal ion binding
Molecular Functionmetallopeptidase activity
Molecular Functionpeptidyl-dipeptidase activity
Molecular Functionvirus receptor activity
Biological Processangiotensin-mediated drinking behavior
Biological Processentry receptor-mediated virion attachment to host cell
Biological Processmaternal process involved in female pregnancy
Biological Processnegative regulation of ERK1 and ERK2 cascade
Biological Processnegative regulation of signaling receptor activity
Biological Processnegative regulation of smooth muscle cell proliferation
Biological Processpositive regulation of gap junction assembly
Biological Processpositive regulation of L-proline import across plasma membrane
Biological Processproteolysis
Biological Processregulation of cardiac conduction
Biological Processregulation of transmembrane transporter activity

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Angiotensin-converting enzyme
  • EC number

Gene names

    • Name
      Ace2

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • C57BL/6J
    • CD1
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q3URC9

Organism-specific databases

Subcellular Location

Apical cell membrane
Cell membrane
; Single-pass type I membrane protein
Cell projection, cilium
Cytoplasm
Secreted

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane741-765Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-17
ChainPRO_501430921818-805Angiotensin-converting enzyme
Glycosylation53N-linked (GlcNAc...) asparagine
Disulfide bond133↔141
Disulfide bond344↔361
Disulfide bond530↔542
Glycosylation578N-linked (GlcNAc...) asparagine; partial

Keywords

Expression

Gene expression databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain614-805Collectrin-like
Region771-805Disordered
Compositional bias790-805Polar residues

Sequence similarities

Belongs to the peptidase M2 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    805
  • Mass (Da)
    92,368
  • Last updated
    2005-10-11 v1
  • Checksum
    D8B883AAC966A8D9
MSSSSWLLLSLVAVTTAQSLTEENAKTFLNNFNQEAEDLSYQSSLASWNYNTNITEENAQKMSEAAAKWSAFYEEQSKTAQSFSLQEIQTPIIKRQLQALQQSGSSALSADKNKQLNTILNTMSTIYSTGKVCNPKNPQECLLLEPGLDEIMATSTDYNSRLWAWEGWRAEVGKQLRPLYEEYVVLKNEMARANNYNDYGDYWRGDYEAEGADGYNYNRNQLIEDVERTFAEIKPLYEHLHAYVRRKLMDTYPSYISPTGCLPAHLLGDMWGRFWTNLYPLTVPFAQKPNIDVTDAMMNQGWDAERIFQEAEKFFVSVGLPHMTQGFWANSMLTEPADGRKVVCHPTAWDLGHGDFRIKMCTKVTMDNFLTAHHEMGHIQYDMAYARQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLPSDFQEDSETEINFLLKQALTIVGTLPFTYMLEKWRWMVFRGEIPKEQWMKKWWEMKREIVGVVEPLPHDETYCDPASLFHVSNDYSFIRYYTRTIYQFQFQEALCQAAKYNGSLHKCDISNSTEAGQKLLKMLSLGNSEPWTKALENVVGARNMDVKPLLNYFQPLFDWLKEQNRNSFVGWNTEWSPYADQSIKVRISLKSALGANAYEWTNNEMFLFRSSVAYAMRKYFSIIKNQTVPFLEEDVRVSDLKPRVSFYFFVTSPQNVSDVIPRSEVEDAIRMSRGRINDVFGLNDNSLEFLGIHPTLEPPYQPPVTIWLIIFGVVMALVVVGIIILIVTGIKGRKKKNETKREENPYDSMDIGKGESNAGFQNSDDAQTSF

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias790-805Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EF408739
EMBL· GenBank· DDBJ
ABN80105.1
EMBL· GenBank· DDBJ
mRNA
EF408740
EMBL· GenBank· DDBJ
ABN80106.1
EMBL· GenBank· DDBJ
mRNA
AK141604
EMBL· GenBank· DDBJ
BAE24759.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp