These data highlight a multifaceted role for neuropilin-1 in memory CD8 T cell differentiation dependent upon the stage of the T cell response and characteristics of the infectious agent.
Findings of indicate that neuropilin-1 (Nrp1) vascular progenitor cells (VPCs) in the act as an important step in the arterial differentiation process.
We show that PTP-3 a LAR homolog in Caenorhabditis elegans participates in Sema2A-regulated axon guidance. PTPdelta a member of vertebrate LAR class PTPs is involved in Sema3A-regulated cortical dendritic growth. In Sema3A signaling PTPdelta activates Fyn and Src kinases by dephosphorylating their C-terminal Tyr residues.
Conditional Nrp1 knockout study does not support the Nrp1 model - that olfactory-derived cAMP signals rather than direct action of olfactory receptor molecules determine the target destinations (glomeruli) of olfactory sensory neurons in the olfactory bulb - for the anterior-posterior patterning of glomerular positions in the olfactory bulb.
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