Genetic determinants of micronucleus formation in vivo.Adams D.J., Barlas B., McIntyre R.E., Salguero I., van der Weyden L., Barros A., Vicente J.R., Karimpour N., Haider A.[...], White J.K.View abstractCategoriesFunctionSourceMGI: 2135607PubMedEurope PMCNature 627:130-136 (2024)Mapped to99+
Sirt6 regulates the proliferation of neural precursor cells and cortical neurogenesis in mice.Wei Y., Wang X., Ma Z., Xiang P., Liu G., Yin B., Hou L., Shu P., Liu W., Peng X.View abstractCategoriesPhenotypes & VariantsSourceMGI: 2135607PubMedEurope PMCiScience 27:108706-108706 (2024)Mapped to61
Screening of an FDA-approved compound library identifies apigenin for the treatment of myocardial injury.Li H., Chen D., Zhang X., Chen M., Zhi Y., Cui W., Li S., Xu F., Tan Y.[...], Chen H.View abstractCategoriesFunctionSourceMGI: 2135607PubMedEurope PMCInt J Biol Sci 19:5233-5244 (2023)Mapped to7
Setd2 deficiency promotes gastric tumorigenesis through inhibiting the SIRT1/FOXO pathway.Feng W., Ma C., Rao H., Zhang W., Liu C., Xu Y., Aji R., Wang Z., Xu J.[...], Li L.View abstractCategoriesFunctionSourceMGI: 2135607PubMedEurope PMCCancer Lett 579:216470-216470 (2023)Mapped to14
Oncogenic KRAS mutation confers chemoresistance by upregulating SIRT1 in non-small cell lung cancer.Shin D.H., Jo J.Y., Choi M., Kim K.H., Bae Y.K., Kim S.S.View abstractCategoriesFunctionSourceMGI: 2135607PubMedEurope PMCExp Mol Med 55:2220-2237 (2023)Mapped to22
Microglial SIRT1 activation attenuates synapse loss in retinal inner plexiform layer via mTORC1 inhibition.Yao K., Mou Q., Lou X., Ye M., Zhao B., Hu Y., Luo J., Zhang H., Li X., Zhao Y.View abstractCategoriesFunctionSourceMGI: 2135607PubMedEurope PMCJ Neuroinflammation 20:202-202 (2023)Mapped to14
Autocrine TGF-beta-positive feedback in profibrotic AT2-lineage cells plays a crucial role in non-inflammatory lung fibrogenesis.Enomoto Y., Katsura H., Fujimura T., Ogata A., Baba S., Yamaoka A., Kihara M., Abe T., Nishimura O.[...], Morimoto M.View abstractCategoriesFunctionSourceMGI: 2135607PubMedEurope PMCNat Commun 14:4956-4956 (2023)Mapped to40
Sirt1 protects against intervertebral disc degeneration induced by 1,25- dihydroxyvitamin D insufficiency in mice by inhibiting the NF-kappaB inflammatory pathway.Wang P., Yang C., Lu J., Ren Y., Goltzman D., Miao D.View abstractCategoriesPTM / ProcessingSourceMGI: 2135607PubMedEurope PMCJ Orthop Translat 40:13-26 (2023)Mapped to15
Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer's Disease.Lopes C.R., Silva J.S., Santos J., Rodrigues M.S., Madeira D., Oliveira A., Moreira-de-Sa A., Lourenco V.S., Goncalves F.Q.[...], Ferreira S.G.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 2135607PubMedEurope PMCInt J Mol Sci 24:6968-6968 (2023)Mapped to7
SIRT1 attenuates blood-spinal cord barrier disruption after spinal cord injury by deacetylating p66Shc.Jiang T., Qin T., Gao P., Tao Z., Wang X., Wu M., Gu J., Chu B., Zheng Z.[...], Yin G.View abstractCategoriesFunctionSourceMGI: 2135607PubMedEurope PMCRedox Biol 60:102615-102615 (2023)Mapped to12
SIRT1 haplo-insufficiency results in reduced cortical bone thickness, increased porosity and decreased estrogen receptor alpha in bone in adult 129/Sv female mice.Artsi H., Cohen-Kfir E., Shahar R., Kalish-Achrai N., Lishinsky N., Dresner-Pollak R.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 2135607PubMedEurope PMCFront Endocrinol (Lausanne) 13:1032262-1032262 (2022)Mapped to19
O-GlcNAcylation of SIRT1 Protects against Cold Stress-Induced Skeletal Muscle Damage via Amelioration of Mitochondrial Homeostasis.Cao Y., Zhang M., Li Y., Lu J., Zhou W., Li X., Shi H., Xu B., Li S.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 2135607PubMedEurope PMCInt J Mol Sci 23:14520-14520 (2022)Mapped to11
Sirtuin 1 aggravates hypertrophic heart failure caused by pressure overload via shifting energy metabolism.Van Le T.N., Zoungrana L.I., Wang H., Fatmi M.K., Ren D., Krause-Hauch M., Li J.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 2135607PubMedEurope PMCBiochem Biophys Res Commun 637:170-180 (2022)Mapped to9
Endothelial SIRT-1 has a critical role in the maintenance of capillarization in brown adipose tissue.Furuuchi R., Shimizu I., Yoshida Y., Katsuumi G., Suda M., Kubota Y., Walsh K., Minamino T.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 2135607PubMedEurope PMCiScience 25:105424-105424 (2022)Mapped to7
Sirt1 Regulates Corneal Epithelial Migration by Deacetylating Cortactin.Lin Y., Liu Q., Li L., Yang R., Ye J., Yang S., Luo G., Reinach P.S., Yan D.View abstractCategoriesFunctionSourceMGI: 2135607PubMedEurope PMCInvest Ophthalmol Vis Sci 63:14-14 (2022)Mapped to16
A Therapeutically Targetable NOTCH1-SIRT1-KAT7 Axis in T-cell Leukemia.Lancho O., Singh A., da Silva-Diz V., Aleksandrova M., Khatun J., Tottone L., Nunes P.R., Luo S., Zhao C.[...], Herranz D.View abstractCategoriesFunctionSourceMGI: 2135607PubMedEurope PMCBlood Cancer Discov 4:12-33 (2023)Mapped to10
Bergenin ameliorates airway inflammation and remodeling in asthma by activating SIRT1 in macrophages to regulate the NF-kappaB pathway.Huang D., Sun C., Chen M., Bai S., Zhao X., Wang W., Geng K., Huang W., Zhao T.[...], Xu Y.View abstractCategoriesFunction, ExpressionSourceMGI: 2135607PubMedEurope PMCFront Pharmacol 13:994878-994878 (2022)Mapped to9
A neuronal action of sirtuin 1 suppresses bone mass in young and aging mice.Luo N., Mosialou I., Capulli M., Bisikirska B., Lin C.S., Huang Y.Y., Shyu P.T., Guo X.E., Economides A.[...], Kousteni S.View abstractCategoriesFunctionSourceMGI: 2135607PubMedEurope PMCJ Clin Invest 132:e152868-e152868 (2022)Mapped to11
SIRT1 inactivation switches reactive astrocytes to an antiinflammatory phenotype in CNS autoimmunity.Zhang W., Xiao D., Li X., Zhang Y., Rasouli J., Casella G., Boehm A., Hwang D., Ishikawa L.L.[...], Zhang G.X.View abstractCategoriesFunctionSourceMGI: 2135607PubMedEurope PMCJ Clin Invest 132:e151803-e151803 (2022)Mapped to7
Activation of SIRT1 promotes membrane resealing via cortactin.Iwahara N., Azekami K., Hosoda R., Nojima I., Hisahara S., Kuno A.View abstractCategoriesFunctionSourceMGI: 2135607PubMedEurope PMCSci Rep 12:15328-15328 (2022)Mapped to7
MiR-34a-5p promotes hepatic gluconeogenesis by suppressing SIRT1 expression.Wang Y., Zhou F., Li M., Zhang Y., Li N., Shao L.View abstractCategoriesFunction, ExpressionSourceMGI: 2135607PubMedEurope PMCExp Cell Res 420:113336-113336 (2022)Mapped to13
Dendritic cell Piezo1 directs the differentiation of T<sub>H</sub>1 and T<sub>reg</sub> cells in cancer.Wang Y., Yang H., Jia A., Wang Y., Yang Q., Dong Y., Hou Y., Cao Y., Dong L.[...], Liu G.View abstractCategoriesFunctionSourceMGI: 2135607PubMedEurope PMCElife 11:e79957-e79957 (2022)Mapped to22
Sirt1 overexpression improves senescence-associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL-11 transcription.Zhou J., Chen H., Wang Q., Chen S., Wang R., Wang Z., Yang C., Chen A., Zhao J.[...], Jin J.View abstractCategoriesFunctionSourceMGI: 2135607PubMedEurope PMCAging Cell 21:e13680-e13680 (2022)Mapped to11
Lef1 ablation alleviates cartilage mineralization following posttraumatic osteoarthritis induction.Elayyan J., Carmon I., Zecharyahu L., Batshon G., Maatuf Y.H., Reich E., Dumont M., Kandel L., Klutstein M., Dvir-Ginzberg M.View abstractCategoriesFunctionSourceMGI: 2135607PubMedEurope PMCProc Natl Acad Sci U S A 119:e2116855119-e2116855119 (2022)Mapped to18
Loss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemia.Wang Z., Zhang C., Warden C.D., Liu Z., Yuan Y.C., Guo C., Wang C., Wang J., Wu X.[...], Chen W.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 2135607PubMedEurope PMCCommun Biol 5:396-396 (2022)Mapped to7