Q3UMU9 · HDGR2_MOUSE

  • Protein
    Hepatoma-derived growth factor-related protein 2
  • Gene
    Hdgfl2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350).
Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350).
Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (By similarity).
Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (By similarity).
Involved in cellular growth control, through the regulation of cyclin D1 expression (By similarity).
Associates with chromatin (PubMed:22212508).

Isoform 1

Binds to condensed chromatin in mitotic cells.

Isoform 3

Binds to condensed chromatin in mitotic cells.

Isoform 4

Binds to non-condensed chromatin in the presence of HDGF.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functionchromatin binding
Molecular FunctionH3K27me3 modified histone binding
Molecular FunctionH3K9me3 modified histone binding
Molecular Functionhistone reader activity
Molecular Functionmethylated histone binding
Biological ProcessDNA recombination
Biological ProcessDNA repair
Biological ProcessDNA repair-dependent chromatin remodeling
Biological Processmuscle cell differentiation
Biological Processmuscle organ development
Biological Processpositive regulation of cell growth
Biological Processpositive regulation of double-strand break repair via homologous recombination
Biological Processskeletal muscle tissue regeneration

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Hepatoma-derived growth factor-related protein 2
  • Short names
    HRP-2

Gene names

    • Name
      Hdgfl2
    • Synonyms
      Hdgfrp2

Organism names

  • Taxonomic identifier
  • Strains
    • BALB/cJ
    • C57BL/6J
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q3UMU9
  • Secondary accessions
    • D6CHX5
    • O35540
    • Q3UIH6
    • Q99L92

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm

Isoform 1

Nucleus

Isoform 3

Nucleus

Isoform 4

Nucleus
Note: Displays a punctate pattern and colocalizes with N-terminally processed HDFG.

Keywords

Phenotypes & Variants

Disruption phenotype

Mice show severely impaired post-injury muscle regeneration.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis523-524Loss of interaction with SMARCA4.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 25 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, modified residue, cross-link.

Type
IDPosition(s)Description
ChainPRO_00003176441-669Hepatoma-derived growth factor-related protein 2
Modified residue114Phosphoserine
Modified residue137Phosphoserine
Modified residue165Phosphoserine
Modified residue229Phosphoserine
Modified residue231Phosphoserine
Modified residue233Phosphoserine
Modified residue239Phosphoserine
Modified residue268Phosphoserine
Modified residue307Phosphoserine
Modified residue366Phosphoserine
Modified residue367Phosphoserine
Modified residue391Phosphoserine
Modified residue392Phosphoserine
Modified residue393Phosphoserine
Modified residue395Phosphoserine
Modified residue450Phosphoserine
Modified residue454Phosphoserine
Cross-link550Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Modified residue567In isoform Q3UMU9-4; Phosphoserine
Modified residue619In isoform Q3UMU9-2; Phosphoserine
Modified residue620Phosphoserine
Modified residue628Phosphoserine
Modified residue629Phosphoserine
Modified residue635Phosphoserine
Modified residue640Phosphoserine
Modified residue659Phosphoserine
Modified residue661Phosphoserine
Modified residue669Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Ubiquitously expressed.

Gene expression databases

Interaction

Subunit

Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3). Interacts with trimethylated 'Lys-79' of histone H3 (H3K79me3), but has higher affinity for H3K36me3 (By similarity).
Interacts with IWS1 (By similarity).
Interacts with H2AX, POGZ, RBBP8 and CBX1 (By similarity).
Interacts with histones H3K9me3, H3K27me3 and H3K36me2 (By similarity).
Interacts with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350).
Interacts with SMARCA4/BRG1/BAF190A, in a DPF3a-dependent manner (PubMed:32459350).
Interacts with SMARCC1/BAF155 and SMARCD1/BAF60A in a DPF3a-dependent manner (By similarity).

Isoform 1

Interacts with HDGF.

Isoform 3

Interacts with HDGF.

Isoform 4

Selectively interacts with HDGF (N-terminally processed form).

Binary interactions

TypeEntry 1
Entry 2Number of experimentsIntAct
BINARY Q3UMU9Hdgf P518594EBI-7627961, EBI-2943087
BINARY Q3UMU9-1Hdgf P518594EBI-7627862, EBI-2943087
BINARY Q3UMU9-3Hdgf P518594EBI-7627932, EBI-2943087

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias, coiled coil.

Type
IDPosition(s)Description
Domain7-64PWWP
Region87-469Disordered
Compositional bias111-125Basic and acidic residues
Compositional bias140-158Basic and acidic residues
Compositional bias190-213Basic and acidic residues
Compositional bias225-243Basic and acidic residues
Compositional bias249-271Polar residues
Compositional bias272-299Basic and acidic residues
Compositional bias309-381Basic and acidic residues
Compositional bias397-411Basic and acidic residues
Compositional bias421-469Basic and acidic residues
Region466-548Interaction with DPF3/BAF45C isoform 2
Coiled coil550-575
Compositional bias558-590Basic and acidic residues
Region558-669Disordered
Compositional bias605-663Basic and acidic residues

Sequence similarities

Belongs to the HDGF family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete

This entry describes 4 isoforms produced by Alternative splicing.

Q3UMU9-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    Isoform a
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    669
  • Mass (Da)
    74,291
  • Last updated
    2006-10-17 v1
  • MD5 Checksum
    8B6FB72F6F83896CCA3C15B5BF5D5ED7
MPHAFKPGDLVFAKMKGYPHWPARIDDIADGAVKPPPNKYPIFFFGTHETAFLGPKDLFPYDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPPPVSSSDSEAPEADLGCGSDVDKDKESRRVMTVTAVTTTATSDRMESDSDSDKSSDHSGLKRKTPVLKVSVSKRARRASSDLDQASVSPSEEDSESPSESEKTSDQDFTPEKKTAARPPRRGPLGGRKKKKVPSASDSDSKADSDGAKEEPVVTAQPSPSSSSSSSSSSSSDSDVSVKKPPRGRKPAEKPPPKPRGRRPKPERPPSTSSSDSDSDSGEVDRISEWKRRDEERRRELEARRRREQEEELRRLREQEREEKERRKERAERGGSSGEELEDEEPVKKRSRKARGRGTPSSSDSEPEGELGKEGKKLAKKSQLPGSESARKPGQKEKRGRPDEKPRARPVKVERTRKRSEGLSLERKGEKKKEPSVEERLQKLHSEIKFALKVDNPDVRKCLSALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMAKAAEVYTRLKSRVLGPKVEALQKVNKAGAEKERADNEKLEEQPGEQAPRELAEDEPSTDRSAPVNGEATSQKGENMEDRAQEDGQDSEDGPRGGSSEELHDSPRDNSDPAKPGNERQDHERTRLASESANDDNEDS

Q3UMU9-2

Q3UMU9-3

  • Name
    3
  • Synonyms
    Isoform b
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q3UMU9-4

  • Name
    4
  • Synonyms
    Isoform c
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Features

Showing features for alternative sequence, compositional bias.

Type
IDPosition(s)Description
Alternative sequenceVSP_04764866-118in isoform 4
Compositional bias111-125Basic and acidic residues
Compositional bias140-158Basic and acidic residues
Compositional bias190-213Basic and acidic residues
Alternative sequenceVSP_031117224-225in isoform 3
Compositional bias225-243Basic and acidic residues
Alternative sequenceVSP_031118226in isoform 2
Compositional bias249-271Polar residues
Compositional bias272-299Basic and acidic residues
Compositional bias309-381Basic and acidic residues
Compositional bias397-411Basic and acidic residues
Compositional bias421-469Basic and acidic residues
Compositional bias558-590Basic and acidic residues
Compositional bias605-663Basic and acidic residues
Alternative sequenceVSP_031119635in isoform 2 and isoform 4

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D63850
EMBL· GenBank· DDBJ
BAA22896.1
EMBL· GenBank· DDBJ
mRNA
FN687734
EMBL· GenBank· DDBJ
CBK52221.2
EMBL· GenBank· DDBJ
mRNA
AK143616
EMBL· GenBank· DDBJ
BAE25467.1
EMBL· GenBank· DDBJ
mRNA
AK144669
EMBL· GenBank· DDBJ
BAE25999.1
EMBL· GenBank· DDBJ
mRNA
AK146813
EMBL· GenBank· DDBJ
BAE27453.1
EMBL· GenBank· DDBJ
mRNA
AK146918
EMBL· GenBank· DDBJ
BAE27530.1
EMBL· GenBank· DDBJ
mRNA
BC003741
EMBL· GenBank· DDBJ
AAH03741.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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