the aim of the present study was to examine murine (m) P2rx7 and human (h) P2RX7 gene expression in graft-versus-host disease target organs of humanised mice and further characterise disease impact in these organs.
In the brain samples expressions of P2Y4 and P2X7 were significantly reduced whereas that of P2Y1 was significantly elevated in an age-dependent manner.
results show that the P2X7 has a key role during inflammation development in inflammatory bowel disease by triggering the death and retention in the mesenteric lymph nodes of regulatory T cells that would otherwise promote immune system tolerance in the gut.
The high expression of P2X7 receptor and low expression of synaptophysin in the hippocampus of pups may contribute to the neurotoxicity associated with maternal Pb exposure.
With the development of leukemia the expression of P2X7R increased in both bone marrow and spleen macrophages whereas expression of P2X1R increased in spleen macrophages.
Purinergic P2X7 receptors are overexpressed in T cells of Panx1-/- mice and retain their sensitivity to ATP suggesting that purinergic P2X7 receptors take over the lost function of Panx1 channels.
study supports the notion that differences in ovarian surface epithelium apoptosis can be explained by increased P2X7 purinoceptor expression which is regulated during the oestrous cycle
Purinergic signaling is important for cell fate determination during neural differentiation with P2X2 and P2X7 receptors promoting neurogenesis and gliogenesis respectively.
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