Q3UKJ7 · SMU1_MOUSE
- ProteinWD40 repeat-containing protein SMU1
- GeneSmu1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids513 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Involved in pre-mRNA splicing as a component of the spliceosome (By similarity).
Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity).
Required for normal accumulation of IK (By similarity).
Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity).
Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity).
Required for normal accumulation of IK (By similarity).
Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nuclear speck | |
Cellular Component | nucleus | |
Cellular Component | precatalytic spliceosome | |
Cellular Component | U2-type precatalytic spliceosome | |
Biological Process | mRNA splicing, via spliceosome | |
Biological Process | regulation of alternative mRNA splicing, via spliceosome | |
Biological Process | RNA splicing |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameWD40 repeat-containing protein SMU1
- Alternative names
- Cleaved into 1 chains
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ3UKJ7
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Colocalizes with SRSF1 in nuclear speckles.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain, cross-link.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed; alternate | ||||
Sequence: M | ||||||
Modified residue | 1 | N-acetylmethionine | ||||
Sequence: M | ||||||
Chain | PRO_0000424521 | 1-513 | WD40 repeat-containing protein SMU1 | |||
Sequence: MSIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP | ||||||
Modified residue | 2 | N-acetylserine; in WD40 repeat-containing protein SMU1, N-terminally processed | ||||
Sequence: S | ||||||
Chain | PRO_0000237591 | 2-513 | WD40 repeat-containing protein SMU1, N-terminally processed | |||
Sequence: SIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP | ||||||
Cross-link | 379 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Structure
Family & Domains
Features
Showing features for region, domain, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 2-315 | Required for interaction with IK | ||||
Sequence: SIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSF | ||||||
Domain | 6-38 | LisH | ||||
Sequence: ESSDVIRLIMQYLKENSLHRALATLQEETTVSL | ||||||
Domain | 40-92 | CTLH | ||||
Sequence: TVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELRELGA | ||||||
Repeat | 212-253 | WD 1 | ||||
Sequence: GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLK | ||||||
Repeat | 262-303 | WD 2 | ||||
Sequence: MMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFE | ||||||
Repeat | 305-346 | WD 3 | ||||
Sequence: AHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFR | ||||||
Repeat | 347-386 | WD 4 | ||||
Sequence: GHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNT | ||||||
Repeat | 395-436 | WD 5 | ||||
Sequence: GTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFS | ||||||
Repeat | 440-479 | WD 6 | ||||
Sequence: REGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERT | ||||||
Repeat | 482-513 | WD 7 | ||||
Sequence: VHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP |
Domain
The WD repeats assemble into a seven-bladed WD propeller.
Sequence similarities
Belongs to the WD repeat SMU1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q3UKJ7-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length513
- Mass (Da)57,544
- Last updated2006-05-30 v2
- ChecksumCB201E939DCCA188
Q3UKJ7-2
- Name2
- Differences from canonical
- 333-513: Missing
Sequence caution
Features
Showing features for sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 49 | in Ref. 2; BAE26804 | ||||
Sequence: A → V | ||||||
Alternative sequence | VSP_018593 | 333-513 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 346 | in Ref. 2; BAB22820 | ||||
Sequence: R → L | ||||||
Sequence conflict | 452 | in Ref. 1; BAA96656 | ||||
Sequence: P → L | ||||||
Sequence conflict | 466 | in Ref. 1; BAA96656 | ||||
Sequence: L → F |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB044414 EMBL· GenBank· DDBJ | BAA96656.1 EMBL· GenBank· DDBJ | mRNA | ||
AK003493 EMBL· GenBank· DDBJ | BAB22820.1 EMBL· GenBank· DDBJ | mRNA | ||
AK011140 EMBL· GenBank· DDBJ | BAC25322.1 EMBL· GenBank· DDBJ | mRNA | Frameshift | |
AK145982 EMBL· GenBank· DDBJ | BAE26804.1 EMBL· GenBank· DDBJ | mRNA | ||
AK159635 EMBL· GenBank· DDBJ | BAE35249.1 EMBL· GenBank· DDBJ | mRNA | ||
AK168813 EMBL· GenBank· DDBJ | BAE40640.1 EMBL· GenBank· DDBJ | mRNA | ||
BC057446 EMBL· GenBank· DDBJ | AAH57446.1 EMBL· GenBank· DDBJ | mRNA |