Q3UKJ7 · SMU1_MOUSE

  • Protein
    WD40 repeat-containing protein SMU1
  • Gene
    Smu1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Involved in pre-mRNA splicing as a component of the spliceosome (By similarity).
Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity).
Required for normal accumulation of IK (By similarity).
Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnuclear speck
Cellular Componentnucleus
Cellular Componentprecatalytic spliceosome
Cellular ComponentU2-type precatalytic spliceosome
Biological ProcessmRNA splicing, via spliceosome
Biological Processregulation of alternative mRNA splicing, via spliceosome
Biological ProcessRNA splicing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • Name
      Smu1

Organism names

  • Taxonomic identifier
  • Strains
    • 129
    • ICR
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q3UKJ7
  • Secondary accessions
    • Q6PFR6
    • Q8BMY4
    • Q9D1I8
    • Q9JJ70

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Nucleus
Nucleus speckle
Note: Colocalizes with SRSF1 in nuclear speckles.

Keywords

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain, cross-link.

TypeIDPosition(s)Description
Initiator methionine1Removed; alternate
Modified residue1N-acetylmethionine
ChainPRO_00004245211-513WD40 repeat-containing protein SMU1
Modified residue2N-acetylserine; in WD40 repeat-containing protein SMU1, N-terminally processed
ChainPRO_00002375912-513WD40 repeat-containing protein SMU1, N-terminally processed
Cross-link379Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)

Keywords

Proteomic databases

PTM databases

Expression

Developmental stage

At 10.5 dpc expressed in otic vesicle.

Gene expression databases

Interaction

Subunit

Component of the spliceosome B complex. Interacts with IK.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, domain, repeat.

TypeIDPosition(s)Description
Region2-315Required for interaction with IK
Domain6-38LisH
Domain40-92CTLH
Repeat212-253WD 1
Repeat262-303WD 2
Repeat305-346WD 3
Repeat347-386WD 4
Repeat395-436WD 5
Repeat440-479WD 6
Repeat482-513WD 7

Domain

The WD repeats assemble into a seven-bladed WD propeller.

Sequence similarities

Belongs to the WD repeat SMU1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q3UKJ7-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    513
  • Mass (Da)
    57,544
  • Last updated
    2006-05-30 v2
  • Checksum
    CB201E939DCCA188
MSIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP

Q3UKJ7-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Sequence caution

The sequence BAC25322.1 differs from that shown. Reason: Frameshift

Features

Showing features for sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict49in Ref. 2; BAE26804
Alternative sequenceVSP_018593333-513in isoform 2
Sequence conflict346in Ref. 2; BAB22820
Sequence conflict452in Ref. 1; BAA96656
Sequence conflict466in Ref. 1; BAA96656

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB044414
EMBL· GenBank· DDBJ
BAA96656.1
EMBL· GenBank· DDBJ
mRNA
AK003493
EMBL· GenBank· DDBJ
BAB22820.1
EMBL· GenBank· DDBJ
mRNA
AK011140
EMBL· GenBank· DDBJ
BAC25322.1
EMBL· GenBank· DDBJ
mRNA Frameshift
AK145982
EMBL· GenBank· DDBJ
BAE26804.1
EMBL· GenBank· DDBJ
mRNA
AK159635
EMBL· GenBank· DDBJ
BAE35249.1
EMBL· GenBank· DDBJ
mRNA
AK168813
EMBL· GenBank· DDBJ
BAE40640.1
EMBL· GenBank· DDBJ
mRNA
BC057446
EMBL· GenBank· DDBJ
AAH57446.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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