Q3UJK6 · Q3UJK6_MOUSE

  • Protein
    NAD-dependent protein deacetylase
  • Gene
    Sirt2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

NAD-dependent protein deacetylase.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site48-52NAD+ (UniProtKB | ChEBI)
Binding site58-60NAD+ (UniProtKB | ChEBI)
Binding site130-133NAD+ (UniProtKB | ChEBI)
Active site150Proton acceptor
Binding site158Zn2+ (UniProtKB | ChEBI)
Binding site163Zn2+ (UniProtKB | ChEBI)
Binding site184Zn2+ (UniProtKB | ChEBI)
Binding site187Zn2+ (UniProtKB | ChEBI)
Binding site224-225NAD+ (UniProtKB | ChEBI)
Binding site248-250NAD+ (UniProtKB | ChEBI)
Binding site286NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcentriole
Cellular Componentmicrotubule
Cellular Componentmidbody
Cellular Componentmyelin sheath
Cellular Componentspindle
Molecular FunctionNAD+ binding
Molecular FunctionNAD-dependent histone deacetylase activity
Molecular FunctionNAD-dependent protein demyristoylase activity
Molecular FunctionNAD-dependent protein depalmitoylase activity
Molecular Functionzinc ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD-dependent protein deacetylase
  • EC number

Gene names

    • Name
      Sirt2

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BALB/C
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q3UJK6

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Proteomic databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain20-300Deacetylase sirtuin-type
Region312-351Disordered
Compositional bias314-328Polar residues

Sequence similarities

Belongs to the sirtuin family. Class I subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    351
  • Mass (Da)
    39,406
  • Last updated
    2005-10-11 v1
  • Checksum
    A610628E55831D1D
MDFLRNLFTQTLGLGSQKERLLDELTLEGVTRYMQSERCRKVICLVGAGISTSAGIPDFRSPSTGLYANLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFIRLLKEKGLLLRCYTQNIDTLERVAGLEPQDLVEAHGTFYTSHCVNTSCRKEYTMGWMKEKIFSEATPRCEQCQSVVKPDIVFFGENLPSRFSCMQSDFSKVDLLIIMGTSLQVQPFASLISKAPLATPRLLINKEKTGQTDPFLGMMMGLGGGMDFDSKKAYRDVAWLGDCDQGCLALADLLGWKKELEDLVRREHANIDAQSGSQAPNPSTTISPGKSPPPAKEAARTKEKEEQQ

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias314-328Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK146412
EMBL· GenBank· DDBJ
BAE27149.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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