Q3UIQ5 · Q3UIQ5_MOUSE
- Protein7-dehydrocholesterol reductase
- GeneDhcr7
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids471 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core. Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta24-sterol reductase (DHCR24) to cholesterol. Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation.
Catalytic activity
- 7-dehydrodesmosterol + NADPH + H+ = desmosterol + NADP+This reaction proceeds in the forward direction.
Pathway
Steroid biosynthesis; cholesterol biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | |
Biological Process | cholesterol biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name7-dehydrocholesterol reductase
- EC number
- Short names7-DHC
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ3UIQ5
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 33-54 | Helical | ||||
Sequence: WFSLASIIFLLLFAPFIVYYFI | ||||||
Transmembrane | 144-161 | Helical | ||||
Sequence: LQAWLITHILWFVNAYLL | ||||||
Transmembrane | 173-193 | Helical | ||||
Sequence: WIPLLWCANILGYAVSTFAMI | ||||||
Transmembrane | 298-316 | Helical | ||||
Sequence: FGWYLGWGDCVWLPYLYTL | ||||||
Transmembrane | 328-347 | Helical | ||||
Sequence: LSTPNALGILLLGLVGYYIF | ||||||
Transmembrane | 411-436 | Helical | ||||
Sequence: SLAYCLACGGGHLLPYFYIIYMTILL |
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-21 | Polar residues | ||||
Sequence: MASKSQHNAPKVKSPNGKAGS | ||||||
Region | 1-23 | Disordered | ||||
Sequence: MASKSQHNAPKVKSPNGKAGSQG |
Sequence similarities
Belongs to the ERG4/ERG24 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length471
- Mass (Da)53,861
- Last updated2005-10-11 v1
- Checksum86B8C35633609291
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-21 | Polar residues | ||||
Sequence: MASKSQHNAPKVKSPNGKAGS |