Q3UFN7 · Q3UFN7_MOUSE

  • Protein
    Transforming growth factor beta
  • Gene
    Tgfb3
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Molecular Functiongrowth factor activity
Molecular Functionidentical protein binding
Molecular Functiontransforming growth factor beta binding
Molecular Functiontype I transforming growth factor beta receptor binding
Molecular Functiontype II transforming growth factor beta receptor binding
Molecular Functiontype III transforming growth factor beta receptor binding
Biological Processcell-cell junction organization
Biological Processdetection of hypoxia
Biological Processface morphogenesis
Biological Processnegative regulation of cell population proliferation
Biological Processnegative regulation of macrophage cytokine production
Biological Processpositive regulation of cell division
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of collagen biosynthetic process
Biological Processpositive regulation of DNA-templated transcription
Biological Processpositive regulation of epithelial to mesenchymal transition
Biological Processresponse to hypoxia
Biological Processresponse to progesterone
Biological Processsalivary gland morphogenesis
Biological Processtransforming growth factor beta receptor signaling pathway
Biological Processtube development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transforming growth factor beta

Gene names

    • Name
      Tgfb3

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q3UFN7

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-23
ChainPRO_501619658824-412Transforming growth factor beta
Disulfide bond307↔316
Disulfide bond315↔378
Disulfide bond344↔409
Disulfide bond348↔411
Disulfide bond377Interchain

Keywords

PTM databases

Interaction

Subunit

Homodimer; disulfide-linked.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain297-412TGF-beta family profile

Sequence similarities

Belongs to the TGF-beta family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    412
  • Mass (Da)
    47,174
  • Last updated
    2005-10-11 v1
  • Checksum
    1F9A660BE3DF3477
MKMHLQRALVVLALLNLATISLSLSTCTTLDFGHIKKKRVETIRGQILSKLRLTSPPEPSVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQETSESEYYAKEIHKFDMIQGLAEHNELAVCPKGITSKVFRFNVSSVEKNGTNLFRAEFRVLRVPNPSSKRTEQRIELFQILRPDEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILENVHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDSPGQGSQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK148385
EMBL· GenBank· DDBJ
BAE28523.1
EMBL· GenBank· DDBJ
mRNA

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