Q3UF95 · Q3UF95_MOUSE
- ProteinLarge proline-rich protein BAG6
- GeneBag6
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1136 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
function
Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | nucleus | |
Biological Process | apoptotic process | |
Biological Process | cell differentiation | |
Biological Process | chromatin organization | |
Biological Process | immune system process | |
Biological Process | spermatogenesis |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameLarge proline-rich protein BAG6
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ3UF95
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 17-77 | Ubiquitin-like | ||||
Sequence: LEVLVKTLDSQTRTFIVGAQMNVKEFKEHIAASVSIPSEKQRLIYQGRVLQDDKKLQEYNV | ||||||
Region | 87-125 | Disordered | ||||
Sequence: RAPPQTQLPSGASSGTGSASATHGGAPLPGTRGPGASVH | ||||||
Compositional bias | 92-107 | Polar residues | ||||
Sequence: TQLPSGASSGTGSASA | ||||||
Compositional bias | 168-202 | Polar residues | ||||
Sequence: RGGTQAQASQPPPQTPQTVASETVALNSQTSEPVE | ||||||
Region | 168-256 | Disordered | ||||
Sequence: RGGTQAQASQPPPQTPQTVASETVALNSQTSEPVESEAPPREPMESEEMEERPPTQTPELAPSGPAPAGPAPAGPAPAPETNAPNHPSP | ||||||
Compositional bias | 205-221 | Basic and acidic residues | ||||
Sequence: APPREPMESEEMEERPP | ||||||
Compositional bias | 225-251 | Pro residues | ||||
Sequence: PELAPSGPAPAGPAPAGPAPAPETNAP | ||||||
Region | 369-424 | Disordered | ||||
Sequence: TMTGNGARPPPAPGAEAATPGSAQATSLPPSSTTVDSSTEGAPPPGPAPPPASSHP | ||||||
Compositional bias | 388-408 | Polar residues | ||||
Sequence: PGSAQATSLPPSSTTVDSSTE | ||||||
Region | 445-513 | Disordered | ||||
Sequence: QDSGAQPGGVPSAPTGPLGPPGHGQTLGQQVPGFPTAPTRVVIARPTPPQARPSHPGGPPVSGALQGAG | ||||||
Region | 550-608 | Disordered | ||||
Sequence: AQAQAQAQAQAQAPAPAPAPAPAPATASASAGTTNTATTAGPAPGGPAQPPPPQPSAAD | ||||||
Compositional bias | 576-591 | Polar residues | ||||
Sequence: ASASAGTTNTATTAGP | ||||||
Region | 655-701 | Disordered | ||||
Sequence: QASQTAPPPPPPPPPPPPAPEQQSTPPPGSPSGGTASPGGLGPESLP | ||||||
Compositional bias | 658-687 | Pro residues | ||||
Sequence: QTAPPPPPPPPPPPPAPEQQSTPPPGSPSG | ||||||
Region | 950-1136 | Disordered | ||||
Sequence: PPQTLPEEPMEVQGAERTSPEPQRENASPAPGTTAEEAMSRGPPPAPEGGSRDEQDGASADAEPWAAAVPPEWVPIIQQDIQSQRKVKPQPPLSDAYLSGMPAKRRKTMQGEGPQLLLSEAVSRAAKAAGARPLTSPESLSRDLEAPEVQESYRQQLRSDIQKRLQEDPNYSPQRFPNAHRAFADDP |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,136
- Mass (Da)119,144
- Last updated2005-10-11 v1
- Checksum510A1B9E928F36AC
Computationally mapped potential isoform sequences
There are 9 potential isoforms mapped to this entry
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 92-107 | Polar residues | ||||
Sequence: TQLPSGASSGTGSASA | ||||||
Compositional bias | 168-202 | Polar residues | ||||
Sequence: RGGTQAQASQPPPQTPQTVASETVALNSQTSEPVE | ||||||
Compositional bias | 205-221 | Basic and acidic residues | ||||
Sequence: APPREPMESEEMEERPP | ||||||
Compositional bias | 225-251 | Pro residues | ||||
Sequence: PELAPSGPAPAGPAPAGPAPAPETNAP | ||||||
Compositional bias | 388-408 | Polar residues | ||||
Sequence: PGSAQATSLPPSSTTVDSSTE | ||||||
Compositional bias | 576-591 | Polar residues | ||||
Sequence: ASASAGTTNTATTAGP | ||||||
Compositional bias | 658-687 | Pro residues | ||||
Sequence: QTAPPPPPPPPPPPPAPEQQSTPPPGSPSG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK148796 EMBL· GenBank· DDBJ | BAE28666.1 EMBL· GenBank· DDBJ | mRNA |