Q3UDK0 · Q3UDK0_MOUSE
- ProteinInhibitor of nuclear factor kappa-B kinase subunit alpha
- GeneChuk
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids671 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Publications for Q3UDK0
IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes.
- CategoriesSequences
- SourceMGI: 99484
Cited inMapped toDifferential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1.
- CategoriesFunction, PTM / Processing
- SourceMGI: 99484
CHUK, a new member of the helix-loop-helix and leucine zipper families of interacting proteins, contains a serine-threonine kinase catalytic domain.
- CategoriesSequences
- SourceMGI: 99484
- PubMed
- Europe PMC
- Cell. Mol. Biol. Res. 41:537-549 ()
CHUK, a conserved helix-loop-helix ubiquitous kinase, maps to human chromosome 10 and mouse chromosome 19.
- CategoriesSequences
- SourceMGI: 99484
Loss of Lymphatic IKKalpha Disrupts Lung Immune Homeostasis, Drives BALT Formation, and Protects against Influenza.
- AnnotationLoss of Lymphatic IKKalpha Disrupts Lung Immune Homeostasis Drives BALT Formation and Protects against Influenza.
- SourceGeneRif: 12675
IKK1 aggravates ischemia-reperfusion kidney injury by promoting the differentiation of effector T cells.
- AnnotationIKK1 aggravates ischemia-reperfusion kidney injury by promoting the differentiation of effector T cells.
- CategoriesFunction
- SourceGeneRif: 12675
Non-Oncogene Addiction of pii>KRASpi/i>-Mutant Cancers to IL-1beta via Versican and Mononuclear IKKbeta.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 99484
Biliary NIK promotes ductular reaction and liver injury and fibrosis in mice.
- CategoriesFunction
- SourceMGI: 99484
p62 Promotes Survival and Hepatocarcinogenesis in Mice with Liver-Specific NEMO Ablation.
- CategoriesFunction
- SourceMGI: 99484
Conditional loss of IKKalpha in Osterix + cells has no effect on bone but leads to age-related loss of peripheral fat.
- AnnotationConditional loss of IKKalpha in Osterix + cells has no effect on bone but leads to age-related loss of peripheral fat.
- CategoriesFunction
- SourceGeneRif: 12675
Deficiency of IKKpii>alphapi/i> in Macrophages Mitigates Fibrosis Progression in the Kidney after Renal Ischemia-Reperfusion Injury.
- AnnotationDeficiency of IKKalpha in Macrophages Mitigates Fibrosis Progression in the Kidney after Renal Ischemia-Reperfusion Injury.
- CategoriesFunction
- SourceGeneRif: 12675
The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 99484
Lung Epithelial Signaling Mediates Early Vaccine-Induced CD4<sup>+</sup> T Cell Activation and <i>Mycobacterium tuberculosis</i> Control.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 99484
Deletion of IKK2 in haematopoietic cells of adult mice leads to elevated interleukin-6, neutrophilia and fatal gastrointestinal inflammation.
- AnnotationDeletion of IKK2 in haematopoietic cells of adult mice leads to elevated interleukin-6 neutrophilia and fatal gastrointestinal inflammation.
- CategoriesFunction
- SourceGeneRif: 12675
Critical requirement for BCR, BAFF, and BAFFR in memory B cell survival.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 99484
Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKalpha.
- CategoriesFunction, PTM / Processing
- SourceMGI: 99484
Inducible knockout of CHUK/IKKalpha in adult chondrocytes reduces progression of cartilage degradation in a surgical model of osteoarthritis.
- AnnotationInducible knockout of CHUK/IKKalpha in adult chondrocytes reduces progression of cartilage degradation in a surgical model of osteoarthritis.
- CategoriesFunction, Phenotypes & Variants
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation.
- CategoriesFunction, PTM / Processing
- SourceMGI: 99484