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Q3UD82 · PARP8_MOUSE

  • Protein
    Protein mono-ADP-ribosyltransferase PARP8
  • Gene
    Parp8
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular FunctionNAD+-protein ADP-ribosyltransferase activity
Molecular FunctionNAD+-protein poly-ADP-ribosyltransferase activity
Molecular FunctionNAD+-protein-cysteine ADP-ribosyltransferase activity
Molecular Functionnucleotidyltransferase activity
Biological Processprotein auto-ADP-ribosylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein mono-ADP-ribosyltransferase PARP8
  • EC number
  • Alternative names
    • ADP-ribosyltransferase diphtheria toxin-like 16
      (ARTD16
      )
    • Poly [ADP-ribose] polymerase 8
      (PARP-8
      )

Gene names

    • Name
      Parp8
    • Synonyms
      D13Ertd275e

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q3UD82
  • Secondary accessions
    • Q3UDE4
    • Q3UDU5
    • Q8VCB5
    • Q9CYY3

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain, modified residue.

Type
IDPosition(s)Description
ChainPRO_00002524341-852Protein mono-ADP-ribosyltransferase PARP8
Modified residue332ADP-ribosylcysteine
Modified residue366ADP-ribosylcysteine
Modified residue375ADP-ribosylcysteine
Modified residue394ADP-ribosylcysteine

Post-translational modification

Auto-mono-ADP-ribosylated.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, domain, compositional bias.

Type
IDPosition(s)Description
Region113-134Disordered
Region289-310Disordered
Domain615-842PARP catalytic
Region748-775Disordered
Compositional bias755-775Polar residues

Sequence similarities

Belongs to the ARTD/PARP family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    852
  • Mass (Da)
    95,560
  • Last updated
    2005-10-11 v1
  • MD5 Checksum
    97660B29F57BD318834AD4E259F88515
MGMCSRQERIQKDIDVVIQKSRAEKDCLFADFRYSDSTFTFTYVGGPKSVSYSVHVSEDYPDNTYVSSSENDEDVLVTTDPIPVIFHRIATELRKTNDINCCLSIRSKLQKENGEESRQNSTVEEDSEGDNDSEEFYYGGQVNYDGELHKHPQLEADLSAVRELYGPHAVSLREYGAIDDVDIDLHIDVSFLDEEIAVAWEVIRTEPIIVRLHCSLTQYLNGPVPTVDVFQISTKERFGLGHQLKKIMQTFVSQQWKQSKDKSNCPHGKKLSEKKVKSPLHLFSTLRRSPSYPPPGCGKSKSKLKPEQDGISKTHKLLRRTCSSTVKADDMCAKSHRTFGRSLSSDPRAEQAMSTIKSHKLLGRPCPSAGKQEDCLTLKSHKLLTRSCSGDPRCEHNTNLKPHKLLSRSYSSNLRMEELYGLKNHKLLSKSYSSAPKTSKMEHFKEPNAEGRRLSLTSGLIGILTPSSSSSQPPTNGAKSIPIRDRGFLVQTIEFAEQRIPVLNEYCVVCDEPHVFQNGPMLRPTVCERELCVFAFQTLGVMNEAADEIATGAQVVDLLVSMCRSALESPRKVVIFEPYPSVVDPNDPQMLAFNPRKKNYDRVMKALDSITSIREMTQAPYLEIKKQMDKQDPLAHPLLQWVISSNRSHIVKLPVNRQLKFMHTPHQFLLLSSPPAKESNFRAAKKLFGSTFAFHGSHIENWHSILRNGLVVASNTRLQLHGAMYGSGIYLSPMSSISFGYSGMNKKQKVSSKDEPASSSKSSNASQSQKKGQQSQFLQSRNLKCIALCEVITSPDLHKHGEIWVVPNTDHVCTRFFFVYEDGQVGDANINTQEGGIHKEILRVIGNQTATG

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F8WIK2F8WIK2_MOUSEParp8891
A0A286YCW0A0A286YCW0_MOUSEParp897
A0A286YD73A0A286YD73_MOUSEParp8108
A0A286YDC6A0A286YDC6_MOUSEParp8253

Sequence caution

The sequence AAH21315.1 differs from that shown. Reason: Erroneous initiation
The sequence AAH21881.1 differs from that shown. Reason: Erroneous initiation

Features

Showing features for sequence conflict, compositional bias.

Type
IDPosition(s)Description
Sequence conflict143in Ref. 1; BAE29166
Sequence conflict330in Ref. 2; AAH21881
Sequence conflict570in Ref. 1; BAB28711
Compositional bias755-775Polar residues
Sequence conflict764in Ref. 1; BAE29166

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK013206
EMBL· GenBank· DDBJ
BAB28711.2
EMBL· GenBank· DDBJ
mRNA
AK149918
EMBL· GenBank· DDBJ
BAE29166.1
EMBL· GenBank· DDBJ
mRNA
AK150113
EMBL· GenBank· DDBJ
BAE29317.1
EMBL· GenBank· DDBJ
mRNA
AK150208
EMBL· GenBank· DDBJ
BAE29379.1
EMBL· GenBank· DDBJ
mRNA
BC021315
EMBL· GenBank· DDBJ
AAH21315.1
EMBL· GenBank· DDBJ
mRNA Different initiation
BC021881
EMBL· GenBank· DDBJ
AAH21881.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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