Q3UD82 · PARP8_MOUSE
- ProteinProtein mono-ADP-ribosyltransferase PARP8
- GeneParp8
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids852 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.
Catalytic activity
- L-cysteinyl-[protein] + NAD+ = S-(ADP-D-ribosyl)-L-cysteinyl-[protein] + nicotinamide + H+
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | NAD+-protein ADP-ribosyltransferase activity | |
Molecular Function | NAD+-protein poly-ADP-ribosyltransferase activity | |
Molecular Function | NAD+-protein-cysteine ADP-ribosyltransferase activity | |
Molecular Function | nucleotidyltransferase activity | |
Biological Process | protein auto-ADP-ribosylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein mono-ADP-ribosyltransferase PARP8
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ3UD82
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000252434 | 1-852 | Protein mono-ADP-ribosyltransferase PARP8 | ||
Modified residue | 332 | ADP-ribosylcysteine | |||
Modified residue | 366 | ADP-ribosylcysteine | |||
Modified residue | 375 | ADP-ribosylcysteine | |||
Modified residue | 394 | ADP-ribosylcysteine | |||
Post-translational modification
Auto-mono-ADP-ribosylated.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 113-134 | Disordered | |||
Region | 289-310 | Disordered | |||
Domain | 615-842 | PARP catalytic | |||
Region | 748-775 | Disordered | |||
Compositional bias | 755-775 | Polar residues | |||
Sequence similarities
Belongs to the ARTD/PARP family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length852
- Mass (Da)95,560
- Last updated2005-10-11 v1
- MD5 Checksum97660B29F57BD318834AD4E259F88515
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F8WIK2 | F8WIK2_MOUSE | Parp8 | 891 | ||
A0A286YCW0 | A0A286YCW0_MOUSE | Parp8 | 97 | ||
A0A286YD73 | A0A286YD73_MOUSE | Parp8 | 108 | ||
A0A286YDC6 | A0A286YDC6_MOUSE | Parp8 | 253 |
Sequence caution
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 143 | in Ref. 1; BAE29166 | |||
Sequence conflict | 330 | in Ref. 2; AAH21881 | |||
Sequence conflict | 570 | in Ref. 1; BAB28711 | |||
Compositional bias | 755-775 | Polar residues | |||
Sequence conflict | 764 | in Ref. 1; BAE29166 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK013206 EMBL· GenBank· DDBJ | BAB28711.2 EMBL· GenBank· DDBJ | mRNA | ||
AK149918 EMBL· GenBank· DDBJ | BAE29166.1 EMBL· GenBank· DDBJ | mRNA | ||
AK150113 EMBL· GenBank· DDBJ | BAE29317.1 EMBL· GenBank· DDBJ | mRNA | ||
AK150208 EMBL· GenBank· DDBJ | BAE29379.1 EMBL· GenBank· DDBJ | mRNA | ||
BC021315 EMBL· GenBank· DDBJ | AAH21315.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
BC021881 EMBL· GenBank· DDBJ | AAH21881.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |