Q3UCD9 · Q3UCD9_MOUSE

  • Protein
    Cathepsin D
  • Gene
    Ctsd
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

Catalytic activity

  • Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.
    EC:3.4.23.5 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

141050100150200250300350400
TypeIDPosition(s)Description
Active site97
Active site293

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendosome membrane
Cellular Componentlysosomal membrane
Cellular Componentmembrane raft
Molecular Functionaspartic-type endopeptidase activity
Biological Processlipoprotein catabolic process
Biological Processpositive regulation of apoptotic process
Biological Processpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Processproteolysis
Biological Processregulation of establishment of protein localization

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Cathepsin D
  • EC number

Gene names

    • Name
      Ctsd

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • BALB/C
    • C57BL/6J
    • NOD
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q3UCD9

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

Type
IDPosition(s)Description
Signal1-20
ChainPRO_501430914421-410Cathepsin D
Disulfide bond91↔160
Disulfide bond110↔117
Glycosylation134N-linked (GlcNAc...) asparagine
Glycosylation261N-linked (GlcNAc...) asparagine
Disulfide bond284↔288
Disulfide bond327↔364

Keywords

PTM databases

Expression

Gene expression databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain79-405Peptidase A1

Sequence similarities

Belongs to the peptidase A1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    410
  • Mass (Da)
    44,954
  • Last updated
    2005-10-11 v1
  • Checksum
    DC4928EC46928BF0
MKTPGVLLLILGLLASSSFAIIRIPLRKFTSIRRTMTEVGGSVEDLILKGPITKYSMQSSPKTTEPVSELLKNYLDAQYYGDIGIGTPPQCFTVVFDTGSSNLWVPSIHCKILDIACWVHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCKSDQSKARGIKVEKQIFGEATKQPGIVFVAAKFDGILGMGYPHISVNNVLPVFDNLMQQKLVDKNIFSFYLNRDPEGQPGGELMLGGTDSKYYHGELSYLNVTRKAYWQVHMDQLEVGNELTLCKGGCEAIVDTGTSLLVGPVEEVKELQKAIGAVPLIQGEYMIPCEKVSSLPTVYLKLGGKNYELHPDKYILKVSQGGKTICLSGFMGMDIPPPSGPLWILGDVFIGSYYTVFDRDNNRVGFANAVVL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK150364
EMBL· GenBank· DDBJ
BAE29499.1
EMBL· GenBank· DDBJ
mRNA
AK150579
EMBL· GenBank· DDBJ
BAE29674.1
EMBL· GenBank· DDBJ
mRNA
AK150694
EMBL· GenBank· DDBJ
BAE29773.1
EMBL· GenBank· DDBJ
mRNA
AK150768
EMBL· GenBank· DDBJ
BAE29834.1
EMBL· GenBank· DDBJ
mRNA
AK150946
EMBL· GenBank· DDBJ
BAE29980.1
EMBL· GenBank· DDBJ
mRNA
AK151256
EMBL· GenBank· DDBJ
BAE30245.1
EMBL· GenBank· DDBJ
mRNA
AK151275
EMBL· GenBank· DDBJ
BAE30262.1
EMBL· GenBank· DDBJ
mRNA
AK151374
EMBL· GenBank· DDBJ
BAE30346.1
EMBL· GenBank· DDBJ
mRNA
AK151829
EMBL· GenBank· DDBJ
BAE30724.1
EMBL· GenBank· DDBJ
mRNA
AK151962
EMBL· GenBank· DDBJ
BAE30833.1
EMBL· GenBank· DDBJ
mRNA
AK152036
EMBL· GenBank· DDBJ
BAE30895.1
EMBL· GenBank· DDBJ
mRNA
AK152168
EMBL· GenBank· DDBJ
BAE31001.1
EMBL· GenBank· DDBJ
mRNA
AK152187
EMBL· GenBank· DDBJ
BAE31018.1
EMBL· GenBank· DDBJ
mRNA
AK152188
EMBL· GenBank· DDBJ
BAE31019.1
EMBL· GenBank· DDBJ
mRNA
AK152406
EMBL· GenBank· DDBJ
BAE31193.1
EMBL· GenBank· DDBJ
mRNA
AK152458
EMBL· GenBank· DDBJ
BAE31236.1
EMBL· GenBank· DDBJ
mRNA
AK152567
EMBL· GenBank· DDBJ
BAE31319.1
EMBL· GenBank· DDBJ
mRNA
AK152593
EMBL· GenBank· DDBJ
BAE31342.1
EMBL· GenBank· DDBJ
mRNA
AK152680
EMBL· GenBank· DDBJ
BAE31412.1
EMBL· GenBank· DDBJ
mRNA
AK152828
EMBL· GenBank· DDBJ
BAE31529.1
EMBL· GenBank· DDBJ
mRNA
AK152881
EMBL· GenBank· DDBJ
BAE31566.1
EMBL· GenBank· DDBJ
mRNA
AK152892
EMBL· GenBank· DDBJ
BAE31575.1
EMBL· GenBank· DDBJ
mRNA
AK153191
EMBL· GenBank· DDBJ
BAE31791.1
EMBL· GenBank· DDBJ
mRNA
AK159097
EMBL· GenBank· DDBJ
BAE34813.1
EMBL· GenBank· DDBJ
mRNA
AK159440
EMBL· GenBank· DDBJ
BAE35086.1
EMBL· GenBank· DDBJ
mRNA
AK159512
EMBL· GenBank· DDBJ
BAE35144.1
EMBL· GenBank· DDBJ
mRNA
AK159970
EMBL· GenBank· DDBJ
BAE35523.1
EMBL· GenBank· DDBJ
mRNA
AK166864
EMBL· GenBank· DDBJ
BAE39078.1
EMBL· GenBank· DDBJ
mRNA
AK166938
EMBL· GenBank· DDBJ
BAE39131.1
EMBL· GenBank· DDBJ
mRNA
AK167143
EMBL· GenBank· DDBJ
BAE39288.1
EMBL· GenBank· DDBJ
mRNA
AK167867
EMBL· GenBank· DDBJ
BAE39883.1
EMBL· GenBank· DDBJ
mRNA
AK169139
EMBL· GenBank· DDBJ
BAE40918.1
EMBL· GenBank· DDBJ
mRNA
AK171195
EMBL· GenBank· DDBJ
BAE42305.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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