Q3UAG2 · Q3UAG2_MOUSE

  • Protein
    6-phosphogluconate dehydrogenase, decarboxylating
  • Gene
    Pgd
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.

Catalytic activity

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.

Features

Showing features for binding site, active site.

148350100150200250300350400450
TypeIDPosition(s)Description
Binding site10-15NADP+ (UniProtKB | ChEBI)
Binding site33-35NADP+ (UniProtKB | ChEBI)
Binding site75-77NADP+ (UniProtKB | ChEBI)
Binding site103NADP+ (UniProtKB | ChEBI)
Binding site103substrate; ligand shared between dimeric partners; in other chain
Binding site129-131substrate; ligand shared between dimeric partners; in other chain
Active site184Proton acceptor
Binding site187-188substrate; ligand shared between dimeric partners; in other chain
Active site191Proton donor
Binding site192substrate; ligand shared between dimeric partners; in other chain
Binding site261substrate; ligand shared between dimeric partners; in other chain
Binding site288substrate; ligand shared between dimeric partners; in other chain
Binding site447substrate; ligand shared between dimeric partners
Binding site453substrate; ligand shared between dimeric partners

GO annotations

AspectTerm
Molecular FunctionNADP binding
Molecular Functionphosphogluconate dehydrogenase (decarboxylating) activity
Biological ProcessD-gluconate metabolic process
Biological Processpentose-phosphate shunt

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    6-phosphogluconate dehydrogenase, decarboxylating
  • EC number

Gene names

    • Name
      Pgd

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q3UAG2

Organism-specific databases

PTM/Processing

Proteomic databases

PTM databases

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain180-4706-phosphogluconate dehydrogenase C-terminal

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    483
  • Mass (Da)
    53,246
  • Last updated
    2005-10-11 v1
  • Checksum
    CD0E2F72EEC2831E
MAQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKDMVSKLKKPRRVILLVKAGQAVDDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKAIFQAIAAKVGTGEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMRHEEMAQAFEEWNKTELDSFLIEITANILKYRDTDGKELLPKIRDSAGQKGTGKWTAISALEYGMPVTLIGEAVFARCLSSLKEERVQASQKLKGPKVVQLEGSKKSFLEDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFERNPELQNLLLDDFFKSAVDNCQDSWRRVISTGVQAGIPMPCFTTALSFYDGYRHEMLPANLIQAQRDYFGAHTYELLTKPGEFIHTNWTGHGGSVSSSSYIA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK150490
EMBL· GenBank· DDBJ
BAE29606.1
EMBL· GenBank· DDBJ
mRNA
AK151380
EMBL· GenBank· DDBJ
BAE30352.1
EMBL· GenBank· DDBJ
mRNA
AK151993
EMBL· GenBank· DDBJ
BAE30857.1
EMBL· GenBank· DDBJ
mRNA
AK152758
EMBL· GenBank· DDBJ
BAE31473.1
EMBL· GenBank· DDBJ
mRNA
AK152894
EMBL· GenBank· DDBJ
BAE31577.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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