Study data from human hepatocellular carcinoma (HCC) liver samples human HCC cells and Sgk3 knockout mice model suggest that SGK3 plays a role in transducing helical domain mutant PIK3CA signaling during liver tumor development.
Taken together these data strongly suggest that SGK3 plays a significant role in regulating podocyte function likely by controlling the expression and activity of GSK3.
SGK1 and SGK3 are expressed in multiple microglial cell lines. SGK1 and SGK3 may play an important role in regulating microglial viability and inflammatory responses.
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